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Application of product for detecting gene locus mutation in preparation of product for predicting or evaluating metabolic condition of patient taking tacrolimus

A gene locus, tacrolimus technology, applied in the field of biological detection, can solve the problems of low accuracy and inability to evaluate the shortcomings of tacrolimus synergists, so as to improve the accuracy rate, improve the prediction accuracy, The effect of reliable reference data

Pending Publication Date: 2020-09-15
南昌大学第一附属医院
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Problems solved by technology

[0006] The purpose of the present invention is to address the shortcomings of the low accuracy of targets and products for monitoring and evaluating tacrolimus metabolism in the prior art, and the inability to evaluate the shortcomings of tacrolimus synergists, and provide a method for detecting CYP3A4 rs2242480, rs4646437 Use of products with gene site mutations in the preparation of products for predicting or evaluating the metabolic status of patients after taking tacrolimus

Method used

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  • Application of product for detecting gene locus mutation in preparation of product for predicting or evaluating metabolic condition of patient taking tacrolimus
  • Application of product for detecting gene locus mutation in preparation of product for predicting or evaluating metabolic condition of patient taking tacrolimus
  • Application of product for detecting gene locus mutation in preparation of product for predicting or evaluating metabolic condition of patient taking tacrolimus

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Embodiment 1

[0047] 1. Recipient information:

[0048] This is a retrospective multi-center study, collecting 211 patients who underwent kidney transplantation in the First Affiliated Hospital of Nanchang University and Jiangxi Provincial People's Hospital from November 2005 to August 2019. The inclusion criteria are as follows: (1) patients undergoing renal transplantation for the first time; (2) aged between 18 and 70 years; the exclusion criteria are as follows: (1) patients with graft failure or death after surgery; Patients who replaced TAC with cyclosporine or other immunosuppressants within 1 month. All included patients were clear about the research content and signed the informed consent. The patient's admission time and related basic information (demographic characteristics and clinical data) were tracked and obtained using the hospital's electronic medical record system. According to whether it was combined with Wuzhi capsule, it was divided into TAC + Wuzhi capsule (WZC) grou...

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Abstract

The invention discloses an application of a product for detecting CYP3A4 rs2242480 and CYP3A4 rs4646437 gene locus mutation in preparation of a product for predicting or evaluating the metabolic condition of a patient taking tacrolimus. According to the application, single nucleic acid polymorphisms (SNP) of CYP3A4 rs2242480 and rs4646437 loci of 221 patients with kidney transplantation are determined and clinical combined medication conditions are discussed; genomics and statistical analysis find that combined use of a Wuzhi-capsule (WZC) and a CYP3A4 rs22480-rs4646437 polyploidy is a main factor affecting in vivo metabolism of the tacrolimus; in the aspect of pharmacogenomics, individualized medication of TAC is considered and a dosage prediction scheme of the TAC is formulated; safe, effective, economical and appropriate individualized medication of the TAC is achieved; and a theoretical basis is provided for clinical individualized medication and medication scheme adjustment.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to the use of a product for detecting gene site mutations in the preparation of products for predicting or evaluating the metabolism of patients after taking tacrolimus. Background technique [0002] Organ transplantation is the ultimate means of treatment for end-stage renal disease. It has developed rapidly at home and abroad in recent years. With the release of the "Guidelines for Organ Donation in China" in 2015, the number of kidney transplants performed in China has jumped to the second place in the world by 2017. However, immune rejection after organ transplantation is the main cause of organ transplant failure. Therefore, rational selection of immunosuppressants is the key to preventing postoperative organ transplantation rejection. [0003] Tacrolimus (TAC) is a family of calcineurin inhibitors and has become the first-line treatment drug for the prevention of...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156C12Q2600/106
Inventor 景艳程婧赵梦君潘丹彭洪薇魏筱华欧阳菲璠傅群张怡
Owner 南昌大学第一附属医院
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