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Application of 2'-fucosyllactose to regulation of host intestinal flora and enhancement of intestinal barriers

A technology of fucosyllactose and intestinal flora, applied in the field of biomedicine

Inactive Publication Date: 2020-08-28
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are relatively few studies on the regulation of 2’-FL on intestinal flora in vivo and its probiotic effects.

Method used

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  • Application of 2'-fucosyllactose to regulation of host intestinal flora and enhancement of intestinal barriers
  • Application of 2'-fucosyllactose to regulation of host intestinal flora and enhancement of intestinal barriers
  • Application of 2'-fucosyllactose to regulation of host intestinal flora and enhancement of intestinal barriers

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Experimental program
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Effect test

Embodiment 1

[0028] 1. Establishment of animal infection model

[0029] The purchased BALB / c mice were randomly divided into three groups, 10 in each group, respectively 2'-FL group, MC group and CK group, and entered the intervention period after 1 week of adaptation period. During the intervention period, the 2'-FL group was fed with 50 mg / mL 2'-fucosyllactose, 200 μL per day. The MC group and CK group were intragastrically administered the same amount of normal saline during the intervention period. Eight weeks after the intervention period, the model-making period was entered, and the model-building period was 3 weeks, in which the 2’-FL group and the MC group were given Escherichia coli O157, each about 10 per day. 9 The CFU and CK groups were intragastrically administered equal volume of normal saline. During the modeling period, the 2'-FL group kept intragastric administration of 2'-fucosyllactose, and the other groups kept intragastric administration of normal saline. After the ...

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Abstract

The invention discloses application of 2'-fucosyllactose to regulation of host intestinal flora and enhancement of intestinal barriers, and belongs to the technical field of biological medicine. The new application includes an application of the 2'-fucosyllactose to preparation of drugs for regulating the host intestinal flora and enhancing the intestinal barriers, an application of the 2'-fucosyllactose to preparation of health food for regulating the host intestinal flora and enhancing the intestinal barrier, and an application of the 2'-fucosyllactose to preparation of food for regulating the host intestinal flora and enhancing the intestinal barriers. The situation that the 2'-fucosyllactose has effects in regulating the host intestinal flora and enhancing the intestinal barriers, andcan be used for preventing and relieving intestinal flora disorder and intestinal barrier damage caused by pathogenic bacteria infection and the like is disclosed for the first time.

Description

Technical field: [0001] The invention relates to the application of 2'-fucosyllactose to regulate intestinal flora of a host and enhance intestinal barrier, and belongs to the technical field of biomedicine. Background technique: [0002] In recent years, with the continuous development of gene sequencing technology, the depth of sequencing has been deepened and the cost of sequencing has been continuously reduced. More and more studies have shown the importance of intestinal flora health to human intestinal and systemic health. Common gastrointestinal diseases such as hemorrhagic diarrhea, virus-infected diarrhea, Crohn's disease, and ulcerative colitis have been found to have an important relationship with the imbalance of intestinal flora in patients. Barriers are your best bet for preventing, relieving, and even treating these common gastrointestinal disorders. [0003] The traditional method of regulating the intestinal flora of the host is mainly to directly ingest pr...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61P1/00A23L33/21
CPCA23V2002/00A61K31/702A23L33/21A61P1/00A23V2200/3204Y02A50/30
Inventor 王硕王津邹妍王远一飞
Owner NANKAI UNIV
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