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Application of nitazoxanide in preparation of medicine for preventing and treating interstitial lung diseases

A nitazoxanide, interstitial technology, applied in the field of application of nitazoxanide in the preparation of drugs for the prevention and treatment of interstitial lung disease, can solve the problem of preventing and treating interstitial lung disease, etc. question

Pending Publication Date: 2020-08-18
REYOUNG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no research on the prevention and treatment of interstitial lung disease with nitazoxanide

Method used

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  • Application of nitazoxanide in preparation of medicine for preventing and treating interstitial lung diseases
  • Application of nitazoxanide in preparation of medicine for preventing and treating interstitial lung diseases
  • Application of nitazoxanide in preparation of medicine for preventing and treating interstitial lung diseases

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with the examples, but it does not limit the implementation of the present invention.

[0023] Preparation of nitazoxanide raw material:

[0024] Add 18g of acetylsalicylic acid and 11.9g of thionyl chloride to 180mL of dichloromethane, add 5% DMF, react at 25°C for 4h, and 14.5g of 2-amino-5-nitro Thiazole was added to the reaction system, 10.1 g of triethylamine was added dropwise, and the reaction was stirred for 0.5 h. After the reaction was completed, it was filtered with suction, and the resulting solid was beaten and recrystallized to obtain the target product, nitazoxanide, with a yield of 50%.

[0025] Preparation of Nitazoxanide Tablets:

[0026] 7 mg of hypromellose was dissolved in 63 mg of purified water, and the solution was sprayed on a fluidized powder consisting of a mixture of 500 mg of nitazoxanide, 56 mg of corn starch, 20 mg of sucrose, and 35 mg of sodium starch glycolate. The r...

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Abstract

The invention belongs to the field of medicines, and particularly relates to application of nitazoxanide in preparation of a medicine for preventing and treating interstitial lung diseases. Accordingto the application of nitazoxanide in preparing the medicine for preventing and treating interstitial lung diseases, further, nitazoxanide is nitazoxanide and an in-vivo active metabolite of nitazoxanide. The interstitial lung diseases comprise disease complications caused by coronavirus infection. According to the invention, detailed research is carried out on the improvement of the interstitiallung disease by the nitazoxanide, the variety of medicines for treating the interstitial lung diseases is expanded, and the new application of nitazoxanide is also expanded.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of nitazoxanide in the preparation of drugs for the prevention and treatment of interstitial lung disease. Background technique [0002] Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD), is a large group of lung heterogeneous diseases, including more than 200 lung parenchymal extensive fibrosis and / or inflammation Abnormally characterized pulmonary parenchymal lesions. The clinical features, imaging, lung function, etc. of the manifestations have some similarities, and the pathogenesis and pathological features also have some common characteristics. It mainly invades the surrounding lung tissues, such as alveoli, alveolar walls, alveolar tracts, alveolar septa, bronchioles, tiny blood vessels, and pulmonary interstitium. The cause of the disease is that the abnormal repair of alveolar epithelial cells leads to a large amo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/426A61P11/00A61P31/14
CPCA61K31/426A61P11/00A61P31/14
Inventor 苗得足胡清文王向华杨书华刘德杰李相林胡伟业李峰
Owner REYOUNG PHARMA
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