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A kind of composite dressing for medical wound repair and preparation method thereof

A wound repair and inner layer technology, applied in medical science, bandages, filament/thread forming, etc., can solve problems such as poor mechanical properties, unfavorable wound healing, and less dressings

Active Publication Date: 2021-06-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: there are few dressings with multi-layer structure prepared by electrospinning at present, and the mechanical properties of existing medical dressings are poor, and the use of non-medicinal crosslinking agents (such as glutaraldehyde, etc.) is not conducive to wound healing. Problems such as single function

Method used

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  • A kind of composite dressing for medical wound repair and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as figure 1 As shown, the present embodiment provides a composite dressing for medical wound repair. The dressing has three layers inside, outside and inside: the inner layer 1 in contact with the wound is chitosan / polyvinyl alcohol / oxidized sodium alginate blended in a certain proportion Nanofiber antibacterial layer; the middle layer 2 is an airgel moisture-absorbing layer prepared by sodium alginate / polyvinyl alcohol / sodium carboxymethylcellulose nanofiber membrane by cutting and freeze-drying; the outer layer 3 is a non-woven breathable layer , the inner layer 1, the middle layer 2, and the outer layer 3 are compounded by medical glue, and cut into the same shape and size, so as to obtain a composite dressing for medical wound repair. The thickness of the inner layer of the composite structural dressing is 0.1 mm, the thickness of the middle layer is 1 mm, and the thickness of the outer layer is 1 mm.

[0033] Its preparation method is as follows:

[0034] St...

Embodiment 2

[0045] Such as figure 1 As shown, the present embodiment provides a composite dressing for medical wound repair. The dressing has three layers inside, inside and outside: the inner layer 1 in contact with the wound is chitosan / polyvinyl alcohol / oxidized sodium alginate blended in a certain proportion Nanofiber antibacterial layer; the middle layer 2 is an airgel hygroscopic layer prepared by sodium alginate / polyvinyl alcohol / sodium carboxymethylcellulose nanofiber membrane by cutting and freeze-drying; the outer layer 3 is a non-woven breathable layer , the inner layer 1, the middle layer 2, and the outer layer 3 are compounded by medical glue, and cut into the same shape and size, so as to obtain a composite dressing for medical wound repair. The thickness of the inner layer of the composite structural dressing is 0.2 mm, the thickness of the middle layer is 2 mm, and the thickness of the outer layer is 1 mm.

[0046] Its preparation method is as follows:

[0047] Step 1, p...

Embodiment 3

[0058] Such as figure 1 As shown, the present embodiment provides a composite dressing for medical wound repair. The dressing has three layers inside, inside and outside: the inner layer 1 in contact with the wound is chitosan / polyvinyl alcohol / oxidized sodium alginate blended in a certain proportion Nanofiber antibacterial layer; the middle layer 2 is an airgel hygroscopic layer prepared by sodium alginate / polyvinyl alcohol / sodium carboxymethylcellulose nanofiber membrane by cutting and freeze-drying; the outer layer 3 is a non-woven breathable layer , the inner layer 1, the middle layer 2, and the outer layer 3 are compounded by medical glue, and cut into the same shape and size, so as to obtain a composite dressing for medical wound repair. The thickness of the inner layer of the composite structural dressing is 0.3 mm, the thickness of the middle layer is 3 mm, and the thickness of the outer layer is 1 mm.

[0059] Its preparation method is as follows:

[0060] Step 1, p...

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Abstract

The invention discloses a composite dressing for medical wound repair, which comprises an inner layer, an intermediate layer and an outer layer in contact with the wound, and is characterized in that the inner layer is chitosan / polyvinyl alcohol / oxidized alginic acid A nanofiber antibacterial layer blended with sodium; the middle layer is an airgel moisture-absorbing layer prepared by sodium alginate / polyvinyl alcohol / sodium carboxymethylcellulose nanofiber membrane through shredding, freeze-drying, etc.; The outer layer is a non-woven breathable layer, and the inner layer, the middle layer and the outer layer are compounded by medical glue. The composite dressing of the present invention improves the mechanical properties of the dressing by using the electrospinning technology, and at the same time, the nanofiber membrane airgel prepared according to the electrospinning technology and the post-treatment have high porosity and large surface area, and can While ensuring high moisture absorption and moisturizing performance, it also has excellent air permeability, reduces the diffusion of exudate, and keeps the skin clean. It can be widely used in the recovery treatment of various wounds.

Description

technical field [0001] The invention relates to a preparation method of a composite dressing for medical wound repair, belonging to the field of medical materials. Background technique [0002] The formation of wounds is mainly due to damage to the skin, mucous membrane surface or damage to the integrity of organ tissues. The healing process is complicated, and the wound heals slowly. It is necessary to cover the wound surface with medical dressings and replace them regularly to speed up wound healing and prevent bacterial and dust infection. Traditional medical dressings, such as absorbent cotton yarn, provide moisture absorption and skin protection to a certain extent. However, after moisture absorption, it is easy to cause the dressing to harden, adhere to the damaged tissue, and increase the friction on the wound surface. At the same time, it is easy to cause secondary damage to the skin when changing the dressing, and the antibacterial ability is not good. In the proc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/28A61L15/42B32B5/02B32B5/26B32B7/12D01D5/00D04H1/4382D04H1/728D04H3/005D04H3/02
CPCA61L15/24A61L15/28A61L15/42B32B5/02B32B5/26B32B7/12D01D5/003D04H1/4382D04H1/728D04H3/005D04H3/02C08L5/08C08L5/04C08L29/04C08L1/286
Inventor 张佩华孙玮郭虹高原付少举
Owner DONGHUA UNIV
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