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System for diagnosing steroid-induced femoral head necrosis through molecular marker

A technology of femoral head necrosis and molecular markers, applied in the field of clinical detection, can solve the problem that it is difficult to prevent the development of necrosis

Active Publication Date: 2020-08-11
陈卫衡 +1
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0004] At present, the most effective method for diagnosing femoral head necrosis is MRI examination, and the early diagnosis rate reaches more than 90%. However, it is difficult to prevent the further development of necrosis after diagnosis

Method used

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  • System for diagnosing steroid-induced femoral head necrosis through molecular marker
  • System for diagnosing steroid-induced femoral head necrosis through molecular marker
  • System for diagnosing steroid-induced femoral head necrosis through molecular marker

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Embodiment

[0050] This example is used to illustrate the discovery of biomarkers and the establishment and verification of predictive models of the present disclosure.

[0051] From January 2014 to October 2017, 60 patients diagnosed with SONFH in Wangjing Hospital of China Academy of Chinese Medical Sciences and Zhengzhou Orthopedic Hospital of Traditional Chinese Medicine were collected (including phlegm and blood stasis syndrome group, meridian obstruction syndrome group, liver and kidney deficiency syndrome group) 20 cases in each group) as the disease group; at the same time, 20 cases of patients without femoral head necrosis who received hormone therapy in the Blood Disease Hospital of the Chinese Academy of Medical Sciences were collected as the control group. 80 patients were randomly divided into training set (n=40, phlegm and blood stasis syndrome, meridian blockage syndrome, liver and kidney deficiency syndrome, 10 cases each in the control group) and verification set (n=40, di...

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Abstract

The invention relates to a system for diagnosing steroid-induced femoral head necrosis through a molecular marker. The molecular marker is BIRC3, CBL, LYN, PAK1, PTEN, RAF1 and TLR4. The system and application provided by the invention can be applied to assessing and diagnosing SONFH high-risk population by detecting an expression quantity of the molecular marker, and assisting to make early diagnosis, thereby providing effective evidence for guiding clinical diagnosis and treatment.

Description

technical field [0001] The present disclosure relates to the technical field of clinical detection, in particular to a system for diagnosing steroid-induced necrosis of the femoral head through molecular markers. Background technique [0002] Osteonecrosis of the Femoral Head (ONFH) is a common disease in orthopedics and traumatology. At present, the number of patients in my country has exceeded 10 million, and the number of new patients is 150,000 to 300,000 every year. According to different causes, femoral head necrosis can be divided into traumatic femoral head necrosis and non-traumatic osteonecrosis of the femoral head (Nontraumatic Osteonecrosis of the Femoral Head, NONFH). Receiving glucocorticoid drug treatment, alcoholism and other reasons. [0003] Steroid-induced osteonecrosis of the femoral head (SONFH) is a non-traumatic necrosis of the femoral head caused by long-term use of steroids, and its incidence rate has exceeded that of femoral head necrosis caused by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11G16H50/20G16B30/00
CPCC12Q1/6883G16H50/20C12Q2600/158C12Q2600/166
Inventor 陈卫衡张彦琼林娜李泰贤王荣田
Owner 陈卫衡
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