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Polypeptide for treating metastatic tumors and preparation method and application of polypeptide for treating metastatic tumors

A technology for malignant tumors and tumor cells, applied in the direction of peptide preparation methods, antineoplastic drugs, chemical instruments and methods, etc., can solve the problems of cell damage, toxic side effects, heart damage, etc., and achieve the effect of inhibiting proliferation and non-toxic side effects

Active Publication Date: 2020-08-11
THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High radiation doses destroy or eliminate cancer cells while also damaging normal cells, resulting in severe toxic side effects
Toxic side effects of chemotherapy include nausea, vomiting, hair loss, fatigue, bleeding and infection, and sometimes chemotherapy can cause permanent damage to the heart, lungs, kidneys or reproductive organs, and the side effects last a lifetime
[0005] Chemotherapy drugs are used to kill fast-growing cancer cells, but because the drugs work throughout the body, they also severely damage normal cells
In addition, the results of pre-chemotherapy treatment are obvious, but drug resistance often occurs after a period of time

Method used

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  • Polypeptide for treating metastatic tumors and preparation method and application of polypeptide for treating metastatic tumors
  • Polypeptide for treating metastatic tumors and preparation method and application of polypeptide for treating metastatic tumors
  • Polypeptide for treating metastatic tumors and preparation method and application of polypeptide for treating metastatic tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] An embodiment of the present invention provides a polypeptide for treating malignant tumors, and the amino acid sequence of the polypeptide is shown in SEQ ID No.1. It should be noted that the two cysteines in the polypeptide are connected to form a loop.

Embodiment approach

[0090] While the tumor tissue was stripped from the mice in Test Example 4, the mice were dissected, and the liver, kidney, spleen and lungs of the mice were taken out and fixed with paraformaldehyde. Embedded, sectioned, and subjected to HE staining (the same method as HE staining in Test Example 4). Please refer to the attached Figure 5 .

[0091] attached by Figure 5 It can be seen that compared with the NC group, the liver, kidney, spleen and lung of the mice in the G19 treatment group had no significant changes, and no pathological changes were found. Therefore, the above results indicate that the G19 polypeptide does not cause toxic side effects in vivo.

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Abstract

The invention discloses polypeptide for treating metastatic tumors and a method and application of the polypeptide for treating metastatic tumors, and relates to the technical field of biology. The amino acid sequence of the polypeptide for treating metastatic tumors is shown as SEQ ID No.1. The polypeptide can significantly restrain the capacity of proliferation, clone formation, migration, invasion and / or in vivo tumor growth of metastatic tumor cells and does not have toxic or side effects, and a new way is provided for treatment of the metastatic tumors.

Description

technical field [0001] The present invention relates to the field of biotechnology, in particular to a polypeptide for treating malignant tumors and its preparation method and application. Background technique [0002] Cancer is the second leading cause of death in the world, killing approximately 8.8 million people each year. Globally, nearly one in six deaths is due to cancer. In recent years, due to the accelerated pace of people's life, changes in diet structure, aging population, and environmental pollution, the incidence of solid malignant tumors has been increasing year by year, and it is showing a younger trend. [0003] At present, surgical treatment is still the main method for the treatment of some tumors clinically. However, due to the lack of specific symptoms and signs of early solid malignant tumors, the low rate of patient visits, and the lack of convenient and effective screening methods and the lack of screening methods with high sensitivity and specifici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/00C07K1/00A61K38/16A61P35/00
CPCC07K14/00A61P35/00A61K38/00
Inventor 晏光荣王继重
Owner THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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