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A kind of anti-calcification biological valve material and preparation method thereof

A technology of biological valves and small molecule compounds, applied in the field of anti-calcification biological valve materials and their preparation, to achieve excellent anti-calcification effects, eliminate immunogenicity, and good mechanical properties

Active Publication Date: 2021-05-11
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides an anti-calcification biological valve material and a preparation method thereof, aiming at solving the calcification problem of existing interventional biological valves, while ensuring the mechanical properties of the biological valve material, and improving the mechanical properties of the valve material. Anti-calcification effect, prolonging the service life of the valve

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A method for preparing an anti-calcification biological valve material, the specific process is:

[0030] Soak the cleaned porcine pericardium in a solution of polylysine and hyaluronic acid with a total mass concentration of 0.5% (mass ratio 1:1, pH 7.4, 4° C.) for 24 hours, and take out distilled water for cleaning. Then, 1% glutaraldehyde aqueous solution (pH 7.4, 25° C.) was used to cross-link for 72 hours to prepare a biological heart valve material with anti-calcification properties.

[0031] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).

[0032] After 60 days of subcutaneous implantation in animal rats, it was found that the amount of calcium attached to the traditional glutaraldehyde cross-linked valve was 162.76 mg / g, and the amount of calcium attached to the anti-calcification biological heart valve prepared in this implementa...

Embodiment 2

[0034] A method for preparing an anti-calcification biological valve material, the specific process is:

[0035] The cleaned porcine pericardium was cross-linked in 0.5% glutaraldehyde aqueous solution (pH 7.4, 25° C.) for 4 days. Wash with distilled water. Then soak for 48 hours in a mixture of water-soluble chitosan and alginic acid with a total mass concentration of 0.5% (mass ratio 1:3, pH 10, 37°C) to prepare a biological heart valve material with anti-calcification properties.

[0036] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).

[0037] The 60-day experiment of subcutaneous implantation in animal rats found that the anti-calcification bio-heart valve prepared in this practice has an anti-calcification effect increased by more than 190 times compared with the traditional glutaraldehyde cross-linked valve.

Embodiment 3

[0039] A method for preparing an anti-calcification biological valve material, the specific process is:

[0040] Soak the cleaned porcine pericardium in a mixture of heparin and polyimide with a total mass concentration of 0.3% (mass ratio 1:5, pH 7.4, 25°C) for 24 hours, take out distilled water and wash. Then 0.1% glutaraldehyde aqueous solution (pH 7.4, 25° C.) was used to cross-link for 48 h. Wash with distilled water. Then soak for 72 hours in a mixture of linoleic acid and polyarginine (mass ratio 3:1, pH 9, 25° C.) with a total mass concentration of 1.5%, to prepare a biological heart valve material with anti-calcification properties.

[0041] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).

[0042] The 60-day experiment of subcutaneous implantation in animal rats found that the anti-calcification bio-heart valve prepared in this implem...

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Abstract

The invention discloses an anti-calcification biological valve material and a preparation method thereof. The method is: soaking the biological valve in an anti-calcification solution, and then placing it in a glutaraldehyde solution to continue cross-linking; or soaking the biological valve after glutaraldehyde cross-linking treatment in an anti-calcification solution; or Soak the biological valve in anti-calcification solution, then cross-link in glutaraldehyde solution, and finally soak in anti-calcification solution. The biological heart valve prepared by the method of the invention not only has good mechanical properties, but also has excellent anti-calcification effect.

Description

technical field [0001] The invention belongs to the field of medical materials and medical devices, and in particular relates to an anti-calcification biological valve material and a preparation method thereof. Background technique [0002] Heart valve disease is a common disease of valve degeneration. The traditional treatment for heart valve disease is open heart valve replacement surgery. Thoracotomy is traumatic, high-risk, slow recovery, and requires extracorporeal circulation support, which is unacceptable to many patients. With the advancement of technology, the development trend of valve replacement surgery has changed from surgical thoracotomy to transcatheter minimally invasive interventional surgery in the past ten years. Compared with traditional open-chest valve replacement surgery, minimally invasive interventional heart valve replacement surgery has the advantages of less trauma to patients, faster postoperative recovery, and lower risk, and has become the m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/3625A61L27/3687A61L27/50A61L2400/18A61L2430/20
Inventor 王云兵李高参杨立
Owner SICHUAN UNIV
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