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Bifidobacterium lactis Probio-M8 capable of relieving and treating Parkinson disease and application thereof

A technology for Bifidobacterium lactis and Parkinson's disease, applied in the field of microorganisms, can solve problems such as lack of effective relief and treatment of Parkinson's disease, and achieve the effects of increasing the frequency of spontaneous defecation, reducing the degree of constipation, and reducing the hardness of stool

Inactive Publication Date: 2020-08-07
BEIJING SCITOP BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of this application provides a strain of Bifidobacterium lactis Probio-M8 that can alleviate and treat Parkinson's disease and its application to solve the problem of lack of probiotics that can effectively relieve and treat Parkinson's disease and improve patient anxiety and constipation

Method used

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  • Bifidobacterium lactis Probio-M8 capable of relieving and treating Parkinson disease and application thereof
  • Bifidobacterium lactis Probio-M8 capable of relieving and treating Parkinson disease and application thereof
  • Bifidobacterium lactis Probio-M8 capable of relieving and treating Parkinson disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0068] Experimental example 1 Establishment of clinical trials of Bifidobacterium lactis Probio-M8 intervening in Parkinson's disease population

[0069] A total of 82 volunteers were recruited for the human trial of Bifidobacterium lactis Probio-M8 in the treatment of Parkinson's disease, and a 3-month (M) population experimental intervention was carried out. The test was randomly divided into a probiotic group (48 people) and a placebo group (34 people). Among them, the probiotics group took Madopa+pramipexole+Probio-M8 (3.00×10 10 CFU / day), the placebo group took Madopar+pramipexole+placebo. Three clinical data collections were performed on subjects at the beginning of the trial, namely 0M, 1M and 3M. The clinical data include the investigation of the clinical symptoms of Parkinson's disease and the investigation of constipation, and two questions of "treatment satisfaction" and "possibility of continuing medication" were added to the last questionnaire. Differences be...

experiment example 2

[0072] Experimental example 2 Investigation of clinical symptoms of Parkinson's disease intervened by Bifidobacterium lactis Probio-M8

[0073] The clinical symptoms of Parkinson's disease were investigated by Mini-mental State Examinatio (MMSE), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale-17 (Hamilton Depression Scale-17, HADM-17), Parkinson's Sleep scale (Parkinson's Disease Sleep Scale, PDSS), VAS pain score, Unified Parkinson's Disease Rating Scale-Ⅲ (UnifiedPDRatingScale-III, UPDRS-III) and activities of daily living rating scale (Activitiesofdailyliving, ADL). Among them, the higher the scores of MMSE, PDSS and ADL, the healthier the body, and the lower the score, the more serious the disease. The lower the score of HAMA, HADM-17, VAS pain score and UPDRS-III scale, the healthier the body, and the higher the score, the more serious the disease. The specific investigation results of Parkinson's disease clinical symptoms are shown in Table 2.

[0074] Table...

experiment example 3

[0079] Experimental Example 3 Investigation of Bifidobacterium lactis Probio-M8 Intervening in Parkinson's Disease Constipation

[0080]The survey of Bifidobacterium lactis Probio-M8 intervening in Parkinson's disease constipation was assessed by Patient-Assessment of Constipation Quality Of Life (PAC-QCL) and constipation-related problems (stool properties, defecation effort, stool firmness, feeling of incomplete defecation). , manual assisted defecation, spontaneous defecation times / week and completed defecation times / week). The lower the PAC-QCL score, the healthier the body, and the higher the score, the more serious the disease. Scores of defecation effort, stool firmness, incomplete defecation, and manual assisted defecation are divided into four grades according to severity: 0-3. The higher the score, the more severe the symptoms. 7 seven types of stool, type 1: separate dry balls, like nuts, difficult to pass; type 2: sausage-like, but very hard; type 3: sausage-lik...

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Abstract

The invention discloses a bifidobacterium lactis Probio-M8 capable of relieving and treating Parkinson disease and application thereof. According to the invention, clinical symptom investigation, constipation condition investigation, treatment satisfaction and continuous medicine taking possibility comprehensive evaluation of people finally show that by taking the bifidobacterium lactis Probio-M8while the Parkinson disease treatment medicines medopa and pramipexole are taken, anxiety and depressive emotion of a patient can be obviously reduced, the sleep quality of the patient is improved, the constipation degree of the patient is alleviated, the feces hardness degree, defecation strength and endless defecation feeling are reduced, feces characters are improved, the number of times of spontaneous defecation and the number of times of complete defecation every week are increased, and finally the treatment satisfaction degree and the possibility of continuous medicine taking of the patient are improved, therefore the effects of relieving and treating Parkinson disease, anxiety and constipation are achieved.

Description

technical field [0001] This application relates to the technical field of microorganisms, in particular to a strain of Bifidobacterium lactis Probio-M8 capable of alleviating and treating Parkinson's disease and its application. Background technique [0002] Parkinson's disease (PD) is a common degenerative disease of the central nervous system in middle-aged and elderly people. Lewy body formation caused by abnormal accumulation of synuclein. Clinically, its main features are resting tremor, muscle rigidity, bradykinesia, posture and gait disorder, etc. In addition, it is accompanied by a large number of non-motor symptoms, such as loss of smell, constipation, anxiety, depression, sleep disturbance, etc. Studies have shown that as many as 80% of patients with Parkinson's disease will experience gastrointestinal dysfunction, especially constipation, and this situation occurs before the appearance of motor decline. Geriatric anxiety disorder is a kind of neurosis that wide...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/745A61P25/16A61P1/10A61P25/22A23L33/135A23C9/123C12R1/01
CPCC12N1/20A61K35/745A61P25/16A61P1/10A61P25/22A23L33/135A23C9/1234A23V2002/00C12R2001/01C12N1/205A23V2400/531A23V2200/322
Inventor 刘晓军马杰张凌宇张建军其木格苏都杨慧娟
Owner BEIJING SCITOP BIO TECH CO LTD
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