Application of ophiopogonin compound in preparation of drugs for preventing and treating tumors

The technology of anti-tumor drugs and compounds is applied in the field of use of Ophiopogon saponins in the preparation of drugs for preventing and treating tumors, which can solve the problems of small adverse reactions, unsatisfactory treatment effect of malignant tumors, etc. Broad anti-tumor application prospect, low cost effect

Active Publication Date: 2020-08-07
EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, on the whole, the current treatment effect of malignant tumors is still far from ideal. Therefore, finding safe and effective anti-tumor drugs with less adverse reactions has always been the main goal of tumor drug research and development. Finding effective drugs from natural products and traditional Chinese medicine is a research hotspot. one

Method used

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  • Application of ophiopogonin compound in preparation of drugs for preventing and treating tumors
  • Application of ophiopogonin compound in preparation of drugs for preventing and treating tumors
  • Application of ophiopogonin compound in preparation of drugs for preventing and treating tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Effect of the compound shown in embodiment 1 formula (I) on A549 cell proliferation

[0068] MTT method was used to measure the inhibitory effect of the compound represented by formula (I) on the proliferation of A549 cells, and to investigate whether the compound represented by formula (I) had obvious cytotoxic effect on A549 cells. Dose-response curve can be obtained by plotting tumor cell inhibition rate with different concentrations of compounds shown in formula (I), such as figure 1 shown. Depend on figure 1 It can be seen that the compound shown in formula (I) inhibits the proliferation of A549 cells concentration-dependently, and its IC 50 It was calculated to be 23.62 μg / mL.

Embodiment 2

[0069] Effect of the compound shown in embodiment 2 formula (I) on A375 cell proliferation

[0070] MTT method was used to measure the inhibitory effect of the compound represented by formula (I) on the proliferation of A375 cells, and to investigate whether the compound represented by formula (I) had obvious cytotoxic effect on A375 cells. Dose-response curve can be obtained by plotting tumor cell inhibition rate with different concentrations of compounds shown in formula (I), such as figure 2 shown. Depend on figure 2 It can be seen that the compound shown in formula (I) inhibits the proliferation of A375 cells concentration-dependently, and its IC 50 It was calculated to be 1.937 μg / mL.

Embodiment 3

[0071] Compound shown in embodiment 3 formula (I) is on the influence of MCF-7 cell proliferation

[0072] MTT method was used to measure the inhibitory effect of the compound represented by the formula (I) on the proliferation of MCF-7 cells, and to investigate whether the compound represented by the formula (I) had obvious cytotoxic effect on the MCF-7 cells. Dose-response curve can be obtained by plotting tumor cell inhibition rate with different concentrations of compounds shown in formula (I), such as image 3 shown. Depend on image 3 It can be seen that the compound shown in formula (I) inhibits the proliferation of MCF-7 cells concentration-dependently, and its IC 50 Calculated to be 18.99 μg / mL.

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Abstract

The invention provides the application of an ophiopogonin compound in the preparation of drugs for preventing and treating tumors, wherein the tumor is a benign tumor or a malignant tumor, and the malignant tumor is selected from one or more of lung cancer, liver cancer, stomach cancer, breast cancer, colon cancer, leukemia, multiple myeloma, lymphoma, malignant melanoma, myeloproliferative disease solid tumor or hematological malignant tumor. The invention also provides an anti-tumor pharmaceutical composition, which contains a therapeutically effective amount of the compound shown in the formula (I) or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. As a compound capable of remarkably inhibiting tumor cell proliferation, the compound shown in the formula (I) or the pharmaceutically acceptable salt thereof has the advantages of small potential toxic and side effects, remarkable inhibition of tumor cell proliferation, broad-spectrum cancer resistance, easiness in preparation, low cost and the like, and has a wide anti-tumor application prospect clinically.

Description

technical field [0001] The invention relates to the use of an active ingredient of a Chinese herbal medicine in the preparation of a drug for preventing and / or treating tumors and a pharmaceutical composition containing the active ingredient. Specifically, it relates to the use of the radix saponins or salts thereof in the preparation of drugs for preventing and treating tumors and the pharmaceutical composition containing the radix radix radix saponins or the salts thereof. Background technique [0002] Tumor is a common and frequently-occurring disease, especially malignant tumors, which seriously threaten human health and life, and are now the number one killer of human health. Malignant tumors have now become the leading cause of death worldwide. About 1 / 8 of the world's population deaths are caused by malignant tumors, exceeding the sum of the deaths from AIDS, tuberculosis and malaria. According to statistics, in 2004, the number of deaths from malignant tumors reache...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00
CPCA61K31/7048A61P35/00Y02A50/30
Inventor 李玉娟段昌令马琰岩
Owner EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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