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Antibacterial silver ion compound, non-irritant silver ion antibacterial agent as well as preparation method and application of thereof

A silver ion antibacterial agent and silver ion technology, applied in the field of antibacterial, can solve the problems of reduced antibacterial effect of silver ions, instability of silver nitrate, unfavorable wound healing, etc., and achieve no bad smell and irritation, good stability and compatibility , is conducive to the effect of large-scale production

Pending Publication Date: 2020-08-04
洛阳冠银生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The silver ion antibacterial agent made of silver nitrate as raw material has the following problems: silver nitrate is unstable, and will decompose after a long time so that the antibacterial effect of silver ions is reduced; nitrate is irritating to the skin and harmful to wound healing Also unfavorable, not conducive to the application in skin care cosmetics
In addition, when antibacterial agents containing silver ions are used in gels, dressings, and fabrics to form antibacterial products, silver ions are easily reduced under ultraviolet light to form black silver precipitates, which not only affect the appearance but also affect the antibacterial effect
[0004] In order to improve the stability of silver ions, ammonia water and silver nitrate are often used to form silver-ammonia complex ions, but the ammoniacal smell of silver-ammonia complex ions is heavy and the salt tolerance is poor; there are no nitrate-free electrolytic silver antibacterial agents on the market. However, the concentration of silver ions is low and the antibacterial effect is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The antibacterial silver ion compound in this embodiment is silver acetate glycine, the cation is a coordination cation formed by silver ion and glycine ligand, and the anion is acetate. The preparation method of the antibacterial silver ion compound of the present embodiment is: the silver acetate of 0.03mol and excess sodium glycinate aqueous solution (sodium glycinate aqueous solution is formed by the glycine of 0.07mol and the sodium hydroxide aqueous solution of 20% mass concentration) After mixing and reacting for 2h, it was then concentrated by evaporation to obtain the obtained product.

Embodiment 2

[0047] The antibacterial silver ion compound in this embodiment is silver glycerophosphothreonine, the cation is a coordination cation formed by silver ion and threonine ligand, and the anion is glycerophosphate. Its preparation method refers to the preparation process in Example 1, the only difference is that sodium glycinate is replaced by sodium threonine, and silver acetate is replaced by silver glycerophosphate.

Embodiment 3

[0049] The antibacterial silver ion compound in this embodiment is silver dihydrogen phenylalanine phosphate, the cation is a coordination cation formed by silver ion and phenylalanine ligand, and the anion is dihydrogen phosphate. Its preparation method refers to the preparation process in Example 1, the only difference is that sodium glycinate is replaced by sodium phenylalanine, and silver acetate is replaced by silver dihydrogen phosphate.

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PUM

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Abstract

The invention belongs to the technical field of antibiosis, particularly relates to an antibacterial silver ion compound, which further relates to a non-irritant silver ion antibacterial agent as wellas a preparation method and an application thereof. The cationic ions in the antibacterial silver ion compound are coordination cations formed by silver ions and amino acid ligands. The amino acid ligand is selected from amino acid and / or polypeptide, and the anion is selected from one or more of acetate radical, hydrogen phosphate radical, dihydrogen phosphate radical, glycerol hydrogen phosphate radical, glycerol phosphate radical, lactate radical, glycolate radical, tartrate radical, citrate radical and malate radical. The antibacterial silver ion compound disclosed by the invention has good stability and compatibility, does not generate decomposition discoloration after being placed for a long time, does not have unpleasant odor, has good salt tolerance and is non-irritant. The antibacterial agents such as antibacterial liquid, antibacterial gel and the like prepared by taking the antibacterial silver ion compound as an active ingredient have better antibacterial property, are non-irritant and can be in direct contact with a human body.

Description

technical field [0001] The invention belongs to the field of antibacterial technology, and in particular relates to a silver ion compound for antibacterial, and also relates to a nonirritating silver ion antibacterial agent and its preparation method and application. Background technique [0002] Disinfection and antibacterial products can effectively kill microorganisms such as harmful bacteria, fungi and viruses in nature, and effectively protect human health. Therefore, disinfection and antibacterial products have become an indispensable part of people's lives. Disinfection and antibacterial products can be divided into natural antibacterial agents, organic antibacterial agents and inorganic antibacterial agents according to their natural attributes. Silver ions have extremely strong bactericidal properties and are harmless to humans, so silver-based bactericides are commonly used inorganic bactericides. Silver in the silver-based antibacterial agent has two forms of nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/76C07D233/64A01N59/16A01N37/44A01N43/50A01N43/12A01P1/00A61K8/44A61K8/64A61Q17/00C07K5/062C08K5/00C08L101/00
CPCC07C229/76C07D233/64A01N59/16A01N37/44A01N43/50A01N43/12A61K8/64A61K8/44A61Q17/005C07K5/06052C08K5/0091C08L101/00A61K2800/10
Inventor 张玉清李治通
Owner 洛阳冠银生物科技有限公司
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