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Oligopeptide alcogel or hydroalcoholic gel and preparation method and application thereof

A kind of alcohol gel and gel technology, which is applied in the field of biomaterials and daily chemical products, to achieve the effect of promoting the proliferation of skin fibroblasts, repairing irritation damage, and maintaining the balance of the skin barrier

Inactive Publication Date: 2020-08-04
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some shortcomings in the direct application of oligopeptide compounds

Method used

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  • Oligopeptide alcogel or hydroalcoholic gel and preparation method and application thereof
  • Oligopeptide alcogel or hydroalcoholic gel and preparation method and application thereof
  • Oligopeptide alcogel or hydroalcoholic gel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh 5 mg of palmitoyl hexapeptide-12 and add it to 1 mL of ethanol aqueous solution with a volume fraction of 75%, and raise the temperature to 60°C to obtain a uniformly dispersed solution; place it at 4°C and let it stand for aging for 12 hours to finally obtain palmitoyl hexapeptide-12 hydroalcoholic gel.

[0059] The physical picture of the obtained hydroalcoholic gel is shown in figure 1 , the appearance of the hydroalcoholic gel is uniform and transparent, and it is in a stagnant state after inversion. After pushing and pulling before injection (simulating smearing effect), it can be transformed into a sol state, such as figure 2 shown.

Embodiment 2

[0061] Weigh 1 mg of palmitoyl pentapeptide-4 and add it to 1 mL of propylene glycol aqueous solution with a volume fraction of 45%, stir and dissolve to obtain a uniformly dispersed solution; place it at 4°C, let it stand for aging for 2 hours, and finally obtain palmitoyl hexapeptide-9 in water alcohol gel.

[0062] The obtained palmitoyl hexapeptide-9 hydroalcoholic gel physical picture is as follows image 3 .

Embodiment 3

[0064] Weigh 5 mg of palmitoyl hexapeptide-9 and add it to 1 mL of pentanediol solution, heat up to 40°C to dissolve, and obtain a uniformly dispersed solution; place it at 10°C, let it stand for aging for 6 hours, and finally obtain the alcohol of palmitoyl hexapeptide-9 gel.

[0065] The physical picture of the obtained alcohol gel is as follows Figure 4 (Left), the alcohol gels are all translucent in appearance, and they are in a stagnant state after inversion.

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Abstract

The invention discloses oligopeptide alcogel or hydroalcoholic gel and a preparation method and application thereof. The oligopeptide alcogel or hydroalcoholic gel is prepared from (a) at least one oligopeptide and a derivative thereof; and (b) at least one lower alcohol and / or polyol. The oligopeptide alcogel / alcogel gel is used as a repairing functional component of washing-free antibacterial gel, can promote skin fibroblast proliferation, and has the effects of healing wounds and inhibiting inflammatory response and injuries, so that the skin barrier balance is maintained from the deep layer of the skin, and irritant injuries to the skin due to long-term use of ethanol antibacterial products are repaired.

Description

technical field [0001] The invention belongs to the field of biological materials and daily chemical products, and specifically relates to an oligopeptide alcohol gel or a hydroalcoholic gel and a preparation method thereof, as well as its application as a repairing functional component in a no-wash antibacterial gel. Background technique [0002] Hydroalcoholic gel is a kind of gel material with three-dimensional structure formed in the blend system of water and lower alcohol or polyol. When the water content is zero and contains only alcohol solvent, the gel formed is called alcohol gel. Due to its unique hydrophilicity, high permeability of alcohols, and its special skin feel, hydroalcoholic gels are widely used in the fields of biomedical dressings, pharmaceuticals, and beauty and skin care. [0003] At present, common hydroalcoholic gels are mostly obtained by blending water-soluble polymers with hydroalcoholic solvents. Such as polyacrylic acid copolymers of carbomer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/34A61K8/04A61K9/06A61K47/10A61K47/42A61L26/00A61P17/02A61P29/00A61Q19/00
CPCA61K8/042A61K8/34A61K8/345A61K8/64A61K9/06A61K47/10A61K47/42A61L26/0047A61L26/008A61Q19/00A61P17/02A61P29/00
Inventor 闫学海沈桂芝邢蕊蕊袁成前
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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