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Novel cytoprotective drugs

A technology for drugs and cells, applied in drug combinations, pharmaceutical formulations, preservation of human or animal bodies, etc., can solve the problems of insufficient cell protection mechanism, unable to prevent the reduction and/or destruction of cell functions, etc.

Pending Publication Date: 2020-07-10
巴勒姆移植
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, these cytoprotective mechanisms are sometimes insufficient, insufficient, or induced too late to prevent the reduction and / or destruction of cellular functions (especially loss of more than one cellular function), nor ultimately to delay and / or prevent early cellular die

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0233] Example 1: In an in vitro model of hypoxia and nutrient deprivation, the effects of micafungin and anidulafungin on the survival of human glomerular endothelial cells.

[0234]

[0235]

[0236]

[0237] These results are shown graphically in Figure 1: Micafungin = Figure 1A ; Anidulafungin = Figure 1B .

[0238] in conclusion:

[0239] Since the anidulafungin and micafungin of the present invention have protective effects on human glomerular endothelial cells against hypoxia stress and nutrient deprivation stress, it is shown that the anidulafungin and micafungin of the present invention can be used as cells Protective agents, especially in protecting kidney cells against hypoxia and nutritional deprivation, especially in protecting against ischemia-reperfusion processes.

Embodiment 2

[0240] Example 2: The effect of micafungin on the survival of human proximal tubular epithelial cells in an in vitro model of hypoxia and nutrient deprivation.

[0241]

[0242]

[0243] These results are shown graphically in figure 2 .

[0244] in conclusion:

[0245] Since the micafungin of the present invention has a protective effect on human renal proximal tubular epithelial cells against hypoxia stress and nutrient deprivation stress, it is shown that the micafungin of the present invention can be used as a cytoprotective agent, especially in protecting kidney cells. In terms of resistance to hypoxia and nutritional deprivation, especially in protection from ischemia-reperfusion processes.

Embodiment 3

[0246] Example 3: In an in vitro model of hypoxia and nutrient deprivation, the effects of micafungin and anidulafungin on the survival of human astrocytes.

[0247]

[0248]

[0249]

[0250] These results are shown graphically in Figure 3. Micafungin= Figure 3A ; Anidulafungin = Figure 3B .

[0251] in conclusion:

[0252] Since the anidulafungin and micafungin of the present invention have protective effects on human astrocytes against hypoxia stress and nutrient deprivation stress, it is shown that the anidulafungin and micafungin of the present invention can be used as cells Protective agents, especially in protecting brain cells against hypoxia and nutrient deprivation, especially in protection from ischemia-reperfusion processes.

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PUM

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Abstract

The invention relates to compounds of the echinocandin family or a semi-synthetic derivative thereof or a salt thereof or an ester thereof, or an ester salt thereof which is intended to be used as a cytoprotective drug, particularly as a drug for the prevention and / or protection and / or treatment of cell death and / or of degenerative pathological situations or processes which result in cell death, and even more particularly as a drug for the prevention and / or protection and / or treatment of cell death and / or degenerative pathological situations or processes which result in cell death, when they are associated with ischaemia-reperfusion.

Description

Technical field [0001] The present invention relates to a novel cytoprotective drug, which is used to protect individuals (especially individuals at risk), organs, tissues or cells against the consequences of cell dysfunction. [0002] More specifically, the present invention relates to the use of compounds of the echinocandin family as cytoprotective drugs. [0003] In this article, unless otherwise specified, any occurrence of "echinocandin family compound" shall be understood as "echinocandin family compound or one of its semi-synthetic derivatives or their salts (salts of compounds) Or a salt of a semi-synthetic derivative) or one of their esters (ester of a compound or an ester of a semi-synthetic derivative) or one of their ester salts (a salt of an ester of a compound or a salt of an ester of a semi-synthetic derivative) One". Background technique [0004] The cellular degenerative process can lead to the reduction and / or destruction of cell functions, especially the loss of...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P1/16A61P39/00A61P9/10A61P13/00
CPCA61K38/12A61P1/16A61P39/00A61P9/10A61P13/00A61P13/12A01N1/0226A61K31/519
Inventor P·贝尔纳M·托马斯G·安托马索
Owner 巴勒姆移植
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