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Methods and compositions for treatment of multi-drug resistant tumors

A multi-drug resistance and composition technology, which is applied in drug combination, gene therapy, anti-tumor drugs, etc., can solve problems affecting the sensitivity of tumor cells

Pending Publication Date: 2020-06-19
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether mycoplasma affects the susceptibility of tumor cells to broader cytotoxic insults remains to be explored

Method used

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  • Methods and compositions for treatment of multi-drug resistant tumors
  • Methods and compositions for treatment of multi-drug resistant tumors
  • Methods and compositions for treatment of multi-drug resistant tumors

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Embodiment

[0057] The inventors found that the sensitivity of liver cancer cells to cisplatin, gemcitabine and mitoxantrone was increased by eliminating mycoplasma. Similar to the effect of anti-mycoplasma agents, using the N-terminal of Annexin A2 polypeptide against M. hyorhini ( Mycoplasma hyorhinis ) Disruption of the interaction between membrane protein P37 and host annexin A2 enhanced the sensitivity of HCC97L cells to gemcitabine and mitoxantrone. These results suggest that Mycoplasma induces multidrug resistance in HCC cells, which requires the interaction between P37 and Annexin A2. A similar increase in sensitivity to cisplatin, fluorouracil, and mitoxantrone was reproduced by antimycoplasma therapy in nasopharyngeal carcinoma cells.

[0058] Antibiotics with completely different mechanisms against mycoplasma-containing cancer cells were used: moxifloxacin (MXF), a fluoroquinolone that inhibits topoisomerases; and azithromycin (AZI), an antibiotic that targets ribosomes for p...

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Abstract

Methods for treatment of a multi-drug resistant (MDR) tumor in a subject are disclosed. The methods comprise administering to the subject in need of treatment a therapeutically effective amount of ananti-mycoplasma agent and / or an agent blocking the interaction between membrane protein P37 of mycoplasma and Annexin A2 of host cells of the subject, prior to, at the same time with, or after chemotherapy. Relevant pharmaceutical compositions, kits, uses are also disclosed.

Description

technical field [0001] The present invention relates to methods and compositions for the treatment of multidrug resistant tumors. In some aspects, the invention relates to the use of an anti-mycoplasma agent / blocker as identified herein for the treatment of multidrug resistant tumors, particularly mycoplasma-induced multidrug resistant tumors, in a subject. Background technique [0002] Multidrug resistance (MDR) is a major factor in the survival of cancer cells exposed to several structurally and mechanistically unrelated drugs. Radiation therapy and chemotherapy are known to induce MDR in cancer cells by themselves, while the role of other environmental factors, including biological factors, in cancer MDR has not yet been elucidated. [0003] Mycoplasma are the smallest prokaryotic microorganisms ubiquitously found in epithelial tissues and body cavities (eg, urinary, digestive, and respiratory tracts). Mycoplasma has also been detected in a number of human cancers (eg, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/00A61K39/395A61K48/00
CPCA61P35/00A61K31/7052A61K38/1709A61K45/06A61K31/4709A61K33/243A61K31/136A61K31/708
Inventor 黄奕俊刘丹阳潘俊成胡杨朱珠
Owner SUN YAT SEN UNIV
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