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Genome-edited birds

An editor, coding technology, applied in genetic engineering, tissue culture, genetically modified cells, etc., can solve the problem of no longer economically attractive, unsuitable for meat production, limited feather sex identification, bird specific genetic hybridization, etc. question

Active Publication Date: 2020-06-19
STATE OF ISRAEL MINIST OF AGRI & RURAL DEV AGRI RES ORG (A R O) (VOLCANI CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although easier to perform, feather sexing has the disadvantage of being limited to the specific genetic cross of the bird
Sexing via secondary sex traits is the easiest method to perform but has the disadvantage of requiring birds of both sexes to be reared together for the first week after hatching due to feed cost and feed conversion considerations for the farm Factors may be more expensive than anal / cloacal sexing
[0005] Most importantly, broiler culture optimized for egg production is critical for meat production due to the increasing optimization of meat production on the one hand and egg production on the other. no longer suitable or economically attractive

Method used

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[0198] Reference is now made to the following examples, which together with the foregoing description illustrate some embodiments of the invention in a non-limiting manner.

[0199]Generally, the nomenclature used herein and the laboratory procedures employed in the present invention include molecular, biochemical, microbiological and recombinant DNA techniques. Such techniques are explained fully in the literature. See, eg, Molecular Cloning: A Laboratory Manual, Sambrook et al., (1989); Current Protocols in Molecular Biology, Volumes I-III, Ausubel , R.M., eds. (1994); Ausubel et al., Current Protocols in Molecular Biology, John Wiley and Sons, Baltimore, Maryland (1989); and Perbal, A Practical Guide to Molecular Cloning, vol. John Wiley and Sons, New York (1988); Watson et al, Recombinant DNA, Scientific American Books, New York; Birren et al (eds); Genome Analysis: A Laboratory Manual Series Manual Series), Volumes 1-4, Cold Spring Harbor Laboratory Press, New York (199...

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Abstract

A DNA editing agent is disclosed which comprises a first nucleic acid sequence for eliciting in an inducible manner a lethal phenotype of male chick embryos in an egg of a bird and a second nucleic acid sequence for directing said nucleic acid sequence for effecting said lethal phenotype to a Z chromosome of a cell of the bird. Use of the DNA editing agent is also disclosed.

Description

Background technique [0001] Some of the embodiments of the invention relate to genome edited birds that lay eggs comprising inactive male chick embryos. [0002] Sex separation is an important aspect of the production of all poultry species, but specifically broiler chickens and essentially all layer birds as well as turkeys. For broilers and turkeys, sex separation allows for more appropriate management and feeding according to the needs of the two sexes, as opposed to the sex-neutral rearing that is done in most cases today. Basically, all commercial pullet (hens that will be table egg production) farms utilize sex separation of flocks. Farms cull males, while females are clearly earmarked for egg production. [0003] Currently, there are three methods available for sexing poultry. Day-old chicks can be sexed by anal / cloacal sexing or feather sexing methods. Alternatively, male and female chicks can be housed together until secondary sex characteristics become apparent, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/027C12N15/63C12N15/85C12N5/0735C12N15/90
CPCC12N15/8509C12N15/907C12N5/0611A01K67/0275C12N2510/00A01K2227/30A01K2267/02C12N2800/106
Inventor Y·西纳蒙E·本塔尔科恩
Owner STATE OF ISRAEL MINIST OF AGRI & RURAL DEV AGRI RES ORG (A R O) (VOLCANI CENT)
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