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Self-curing two-component ion and temperature double-sensitive digestive tract mucosa protective glue and preparation method thereof

A mucous membrane protection and ion-sensitive technology, applied in the field of biomedicine, can solve the problems of loss of digestive tract protective gel and low gel strength.

Pending Publication Date: 2020-06-19
戴建英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One-component temperature-sensitive digestive tract protective glue has the problem of loss, and the strength of the glue is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Poloxamer 407 18g

[0022] 2. Poloxamer 188 0.5 g

[0023] 3. Hydroxypropyl methylcellulose 0.5 g

[0024] 4. Sodium alginate 0.3 g

[0025] ———————————————————

[0026] The above ingredients were dissolved in 60ml of pure water at 4°C, and the solution was completely transparent, then the volume was adjusted to 100ml, and each bottle was packaged in 5ml. High temperature steam sterilization. Store at low temperature.

[0027] The solidified solution is formulated into a 1.1% aqueous solution with calcium chloride, packed in 5ml bottles, and sterilized by high-temperature steam.

Embodiment 2

[0029] 1. Poloxamer 407 20g

[0030] 2. Poloxamer 188 1 g

[0031] 3. Hydroxypropyl methylcellulose 0.5 g

[0032] 4. Sodium alginate 0.4 g

[0033] ———————————————————

[0034] The above ingredients were dissolved in 60ml of pure water at 4°C, and the solution was completely transparent, then the volume was adjusted to 100ml, each bottle was packaged in 5ml, and sterilized by high-temperature steam. Store at low temperature.

[0035] The solidified solution is formulated into a 1.1% aqueous solution with calcium chloride, packed in 5ml bottles, and sterilized by high-temperature steam.

Embodiment 3

[0037] 1. Hydroxybutyl Chitosan 5g

[0038] 2. Poloxamer 188 0.5 g

[0039] 3. Collagen 2 grams

[0040] 4. Amidated low methoxyl pectin 1g

[0041] ———————————————————

[0042] The above ingredients were dissolved in 60ml of pure water at 4°C, and the solution was completely transparent, then the volume was adjusted to 100ml, each bottle was packaged in 5ml, and sterilized by high-temperature steam. Store at low temperature.

[0043] The solidification solution is formulated into a 2% aqueous solution with calcium gluconate, packed in 5ml bottles, and sterilized by high-temperature steam.

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PUM

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Abstract

The invention provides a self-curing two-component ion and temperature double-sensitive digestive tract injured mucosa protective glue and a preparation method thereof. The self-curing two-component digestive tract injured mucosa protective glue comprises colloid liquid and fixing liquid. The colloid liquid comprises a temperature sensitive biological material, a gelation temperature regulator, abiological adhesive agent, an ion sensitive fixing agent and a dissolving liquid, and the fixing liquid is a water-soluble calcium solution, wherein the percentage ratio of the temperature sensitive biological material to the gelation temperature regulator to the biological adhesive to the ion sensitive fixing agent is (1-30):(0.5-5):(0.3-5):(0.2-1). The colloid liquid is in a liquid state at a temperature lower than the room temperature, and is sprayed on the mucosa of a digestive tract wound surface; then the fixing liquid is sprayed to avoid loss; and a colloid film is further formed at thebody temperature, so that the stimulation effect of intestinal tract digestive liquid on the digestive tract injured mucosa is avoided, and healing of the wound surface is promoted. Animal tests showthat the protective glue provided by the invention can obviously promote repair of the injured mucosa, and thus has healing promoting and protecting effects on the damage of mucosa of esophagi, stomachs and intestinal tracts.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a self-curing two-component ion- and temperature-sensitive protective adhesive for digestive tract mucosa that is suitable for spraying endoscopes on the surface of the damaged mucosa of the digestive tract and its application. Background technique [0002] Gastrointestinal mucosal injury occurs from the esophagus, stomach, duodenum to rectum, some injuries are caused by diseases, and some are caused by surgery. Endoscopic gastric mucosal resection and gastric mucosal dissection are minimally invasive surgeries for the resection of early gastric cancer and benign gastric tumors. They can not only achieve the goal of radically curing early gastric cancer, but also have the advantages of less trauma and less impact on the quality of life of patients. Gradually replace some traditional surgery. Minimally invasive surgery for early cancer and benign tumor resection of esophagus ...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/02A61L24/04A61L24/08A61L24/06A61L24/10
CPCA61L24/001A61L24/0015A61L24/02A61L24/046A61L24/06A61L24/08A61L24/102A61L2400/00C08L71/02C08L1/284C08L5/04C08L5/08C08L5/06C08L5/00C08L33/24C08L89/00
Inventor 戴建英
Owner 戴建英
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