Application of radix salviae miltiorrhizae extract extracted by supercritical CO2 fluid

Abstract

The invention provides application of a radix salviae miltiorrhizae extract extracted by supercritical CO2 fluid, and relates to the technical field of medicine. The radix salviae miltiorrhizae extract is applied to prevention of metastasis of tumor cells after a tumor resection operation; and the tumor cells are CTCs (Circulating Tumor Cells). By specifically inhibiting the adhesion of trace CTCsto vascular endothelial cells, the anoikis of the trace CTCs in blood is promoted; the metastasis of the CTCs after the tumor operation is effectively prevented; and meanwhile, the problem of drug resistance of the tumor cells is solved.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to supercritical CO 2 Application of Fluid Extraction of Salvia Miltiorrhiza Extract. Background technique [0002] Tumor metastasis is the main cause of death of cancer patients, clinically more than 90% of cancer patients die from tumor metastasis rather than primary tumor ( Hanahan and Weinberg 2011 , Sethi and Kang 2011 ). At present, the number of survivors after cancer surgery in China is estimated to be at least 20 million, and they are facing the risk of tumor recurrence and metastasis. Traditional "anticancer drugs" cannot effectively prevent tumor metastasis due to their severe side effects. Morgan et al. analyzed the results of 22 clinical trials from 1990 to 2004 and found that "anticancer drugs" can only increase the 5-year survival rate of cancer patients by 2.1% ( Morgan, Ward et al.2004 ). Early use of chemotherapy drugs cannot prevent tumor metastasis, but...

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Problems solved by technology

[0004] Existing biological anti-cancer technologies generally discuss the prevention of tumor metastasis from the perspective of tumor cells, but in practice, the treatment of tumor cells, especially after tumor resection, has limited practical effect on the prevention of tumor re-metastasis, and the treatment of tumor cells often Single-target, tumor cells are prone to drug resistance, and cannot truly prevent tumor re-metastasis

[0005] On the other hand, in the prior art, there is no method to prevent tumor metastasis from the perspective of the microenvironment of tumor cells to simultaneously inhibit intercellular adhesion molecule (ICAM-1), tumor cell surface integrin (Integrin) and other related genes. Expression, starting from the microenvironment of tumor cells, effectively and comprehensively inhibits tumor re-metastasis after surgery

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