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Application of Zuotai in preparation of medicine for promoting vorinostat to pass through blood brain barrier

A technology of vorinostat and blood-brain barrier, applied in the field of drug preparation

Pending Publication Date: 2020-05-29
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, SAHA has obstacles in passing the blood-brain barrier, which limits the drug's direct access to the lesion, thereby limiting its efficacy in the treatment of brain diseases

Method used

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  • Application of Zuotai in preparation of medicine for promoting vorinostat to pass through blood brain barrier
  • Application of Zuotai in preparation of medicine for promoting vorinostat to pass through blood brain barrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] drug preparation

[0017] The dosage of SAHA is 30.0mg / kg, and the Tibetan medicine Zuotai is 0.2mg / kg. Preparation of SAHA drug solution: take an appropriate amount of SAHA, add dimethyl sulfoxide (DMSO) and PBS solution (V:V=1:9) to dissolve, and ultrasonically dissolve for 10 minutes for later use. Preparation of Zotai solution: PBS solution is ultrasonically dissolved.

[0018] single dose method

[0019] Grouping and administration: the mice were randomly divided into 24 groups, 3 in each group, and 3 in parallel. SAHA alone 1h, 2h, 3h and 4h administration group and SAHA combined with Zotai administration group for 1h, 2h, 3h and 4h respectively, mice in the joint administration group were intraperitoneally injected with 0.3ml Zotai in advance, after 3 hours each group Rats were intraperitoneally injected with the same dose of drug SAHA.

[0020] Sample collection: 1h, 2h, 3h, and 4h after administration, the mice were sacrificed by decapitation at different t...

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Abstract

The invention relates to application of Zuotai in preparation of a medicine for promoting vorinostat to pass through a blood brain barrier, belonging to the technical field of medicine preparation. According to the application of Zuotai in preparation of the medicine for promoting vorinostat to pass through the blood brain barrier, the combined administration of Zuotai and SAHA (namely vorinostat)can significantly promote the SAHA to pass through the blood brain barrier and to enter brain tissue, and can also significantly promote the accumulation of the medicine in the brain tissue.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to the application of Zotai in the preparation of medicines for promoting vorinostat to pass through the blood-brain barrier. Background technique [0002] Vorinostat (SAHA) is a histone deacetylase (HDAC) inhibitor. Studies in recent years have found that SAHA has a significant effect on improving and restoring the learning ability and memory of senile dementia and animal models, and has a certain healing effect on patients with depression. However, SAHA has obstacles in passing the blood-brain barrier, which limits the drug's direct access to the lesion, thereby limiting its efficacy in the treatment of brain diseases. How to promote SAHA to efficiently pass through the blood-brain barrier is the key to promoting the efficacy of the drug in the treatment of brain diseases. Contents of the invention [0003] The object of the present invention is to provide the app...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K31/167A61P25/28A61P25/24
CPCA61K47/02A61K31/167A61P25/28A61P25/24
Inventor 赵晓辉张婷岳会兰陶吉红贾文静周国英魏立新毕齐茂
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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