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N-benzyl benzamide compound as well as preparation method and application thereof

A benzylbenzamide and compound technology, which is applied in the preparation of organic compounds, the preparation of carboxylic acid amides, botanical equipment and methods, etc., can solve problems such as no N-benzylbenzamide compounds and the like

Inactive Publication Date: 2020-05-29
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the existing literature retrieved by the inventor, there is no report that N-benzylbenzamide compounds are used as herbicides at present

Method used

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  • N-benzyl benzamide compound as well as preparation method and application thereof
  • N-benzyl benzamide compound as well as preparation method and application thereof
  • N-benzyl benzamide compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Preparation of N-(3-fluorobenzylamine)-2-methoxybenzamide (compound A01)

[0052]

[0053]125 grams (1.0mol) of 3-fluorobenzylamine and 150 grams of triethylamine (1.5mol) were dissolved in 1.5L toluene, stirred in an ice bath for 30 minutes, and then 170 grams (1.0 mol) 2-methoxybenzoyl chloride, continue to stir at room temperature for 1.5 hours after adding, add 200 milliliters of saturated sodium bicarbonate solution to wash, then wash with 200 milliliters each of deionized water and saturated saline successively, anhydrous sodium sulfate After drying, the solvent was removed under reduced pressure, and the residue was subjected to silica gel column chromatography to obtain 230 g of the product with a yield of 88.8%.

Embodiment 2

[0054] Example 2 Preparation of N-(4-fluorobenzyl)-2-hydroxyaniline (compound A02)

[0055]

[0056] 125 grams (1.0mol) of 4-fluorobenzylamine and 150 grams of triethylamine (1.5mol) were dissolved in 1.5L toluene, stirred in an ice bath for 30 minutes, and then 170 grams (1.0 mol) 2-methoxybenzoyl chloride, continue to stir at room temperature for 1.5 hours after adding, add 200 milliliters of saturated sodium bicarbonate solution to wash, then wash with 200 milliliters each of deionized water and saturated saline successively, anhydrous sodium sulfate After drying, the solvent was removed under reduced pressure, and the residue was subjected to silica gel column chromatography to obtain 220 g of the product with a yield of 84.9%.

Embodiment 3

[0057] Example 3 Preparation of N-(3,5 difluorobenzyl)-2-methoxybenzamide (compound A03)

[0058]

[0059] 143 grams (1.0mol) of 3,5-difluorobenzylamine and 150 grams of triethylamine (1.5mol) were dissolved in 1.5L of toluene, stirred in an ice bath for 30 minutes, and then added dropwise with 170 Gram (1.0mol) 2-methoxybenzoyl chloride, after adding, continue to stir at room temperature for 1.5 hours, add 200 milliliters of saturated sodium bicarbonate solution to wash, then wash with each 200 milliliters of deionized water and saturated saline successively, without After drying over sodium sulfate, the solvent was removed under reduced pressure, and the residue was subjected to silica gel column chromatography to obtain 245 g of the product, with a yield of 88.4%.

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PUM

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Abstract

The invention provides an N-benzyl benzamide compound as well as a preparation method and application thereof. The N-benzyl benzamide compound is an N-benzyl benzamide compound with a general formulaI or II or a salt thereof. The invention discloses a weeding composition or a mixed preparation taking the N-benzyl benzamide compound or a salt thereof as a component. The dosage of the N-benzyl benzamide compound or a salt thereof is 10 grams to 5 kilograms for each hectare, preferably, the N-benzyl benzamide compound or a salt thereof is applied to soil or weeds by adopting a pre-emergence soiltreatment method or a post-emergence stem and leaf spraying method, and the N-benzyl benzamide compound or a salt thereof can be used as a pigment synthesis inhibitor for preventing and removing weeds in field crop growth places and non-farming crop places.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and specifically relates to a class of N-benzylbenzamide compounds with herbicidal activity. The invention provides the synthesis process and several specific chemical structures of the N-benzylbenzamide compounds The present invention also provides the herbicidal composition and mixed preparation containing said N-benzylbenzamide compound and its application. Background technique [0002] my country is a large agricultural country, with a wide area of ​​crops such as wheat, corn, and rice, as well as economic crops such as coffee, tea, rubber, and fruit trees. Weeds are common in fields and non-cultivated crop sites, and there are many kinds of weeds, mainly broad-leaved weeds such as retroflexus, quinoa, field bindweed, black nightshade, cocklebur, commelina, and amaranth; Gramineae Weeds such as crabgrass, foxtail, goosegrass, bermudagrass, etc.; Cyperaceae weeds such as Cyperus cyperus. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/40A01N43/40C07C231/02C07C235/46C07C233/65C07D213/82A01N43/70A01P13/00
CPCA01N37/40A01N43/40A01N43/70C07C231/02C07D213/82C07C235/46C07C233/65
Inventor 姬志勤魏少鹏
Owner NORTHWEST A & F UNIV
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