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Application of FGL1 (fibrinogen like 1) in diagnosis and/or treatment on lymph node metastasis

A technology for lymph node metastasis and esophageal cancer, applied in the field of diagnosis and/or treatment, which can solve the problem that it is difficult for surgeons to accurately diagnose lymph node metastasis

Pending Publication Date: 2020-05-08
THE SECOND AFFILIATED HOSPITAL OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even during surgery, it is difficult to accurately diagnose lymph node metastasis through the surgeon's eyes and hands

Method used

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  • Application of FGL1 (fibrinogen like 1) in diagnosis and/or treatment on lymph node metastasis
  • Application of FGL1 (fibrinogen like 1) in diagnosis and/or treatment on lymph node metastasis
  • Application of FGL1 (fibrinogen like 1) in diagnosis and/or treatment on lymph node metastasis

Examples

Experimental program
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Embodiment 1

[0043] Materials and Methods

[0044] 1. Experimental materials

[0045] (1) Cell line: The cells used in this example are: esophageal cancer cell Eca-109 cells, which were purchased from the Cell Bank of the Type Culture Collection Committee of the Chinese Academy of Sciences. All cells were subcultured within 6 months after recovery.

[0046] (2) Tumor tissue: 66 esophageal cancer tissue samples obtained from surgery, including 36 esophageal cancer tissues with lymph node metastasis and 30 esophageal cancer tissues without lymph node metastasis. The above tissue samples were obtained from the Affiliated Hospital of Xi'an Jiaotong University. The clinical data of each patient were carefully retrieved and sorted out from the medical records independently by two researchers. The postoperative pathological reports and original medical records of all patients were obtained and sorted out, and the postoperative pathological staging was carried out according to the eighth edition...

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Abstract

The invention relates to a kit for detection and / or treatment on lymph node metastasis. The kit comprises: (1) a detection reagent for detecting expression of FGL1 (fibrinogen like 1), and / or (2) a treatment reagent for inhibiting expression or actions of FGL1. The invention further relates to application of FGL1 or a derivative thereof in preparing a medicine or kit for detection and / or treatmenton lymph node metastasis. The FGL1 can be not only used as a molecular marker of lymph node metastasis, but also applied to preoperative diagnosis and prognosis of lymph node metastasis, and even iscapable of inhibiting lymph node metastasis by inhibiting the FGL1, and thus a treatment function can be achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically, the invention relates to the application of FGL1 in the diagnosis and / or treatment of lymph node metastasis of esophageal cancer. Background technique [0002] Esophageal cancer is the twelfth most common malignant tumor in the world, with the seventh highest mortality rate. my country is a country with a high incidence of esophageal cancer in the world. [0003] Lymph node metastasis is the main way for esophageal cancer to spread, and it can appear in the early stage, and most patients have already appeared at the first visit to the doctor. In general, lymph node metastasis occurs only when the tumor infiltrates beyond a certain depth. However, when the local infiltration of esophageal cancer tumor only reaches the superficial layer (T1 stage, submucosa), the lymph node metastasis rate is as high as 59%, while the lymph node metastasis rate of gastric cancer is less ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/577G01N33/574A61K45/00A61P35/04
CPCC12Q1/6886G01N33/577G01N33/57407G01N33/57484A61K45/00A61P35/04C12Q2600/158C12Q2600/118G01N2333/75
Inventor 黄珊马红兵王亚利任宏涛柯悦
Owner THE SECOND AFFILIATED HOSPITAL OF XIAN JIAOTONG UNIV
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