Biomolecular and temperature dual-parameter optical fiber sensor and its manufacturing method and application

An optical fiber sensor and biomolecular technology, which is applied to thermometers, thermometers, instruments and other directions with physical/chemical changes, can solve the problems of complex sensor structure fabrication process and low detection sensitivity, etc.

Active Publication Date: 2020-10-27
NORTHEASTERN UNIV LIAONING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although it has certain advantages, some sensor structures still have problems such as complex manufacturing process and low detection sensitivity.

Method used

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  • Biomolecular and temperature dual-parameter optical fiber sensor and its manufacturing method and application
  • Biomolecular and temperature dual-parameter optical fiber sensor and its manufacturing method and application
  • Biomolecular and temperature dual-parameter optical fiber sensor and its manufacturing method and application

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Embodiment 1

[0063] This embodiment provides a biomolecule and temperature dual-parameter optical fiber sensor. The biomolecule, namely antigen 8, is papain, and the antibody 7 matched with it is immunoglobulin IgG. Specifically, this embodiment provides a sensor for A dual-parameter fiber optic sensor for the detection of papain and temperature.

[0064] like figure 1 As shown, a biomolecule and temperature dual-parameter optical fiber sensor includes a light-incoming optical fiber 1 , a hollow-core optical fiber 4 , and a light-emitting optical fiber 2 connected in sequence. The incident optical fiber 1 is a multimode optical fiber with a core diameter of 62.5 microns and a cladding diameter of 125 microns. The length can be determined according to the distance of the equipment used in the experiment. The length used in this embodiment is 0.5 meters. The outer diameter of the hollow-core optical fiber 4 is 125 microns, the inner diameter is 35 microns, and the length is 2 cm. The outer...

Embodiment 2

[0085] A dual-parameter optical fiber sensor for biomolecules and temperature, comprising a light-incoming fiber, a hollow-core fiber and a light-outgoing fiber. One end of the core fiber is fused, and the other end of the hollow-core fiber is fused with one end of the output fiber;

[0086] The light-incoming optical fiber is used to input and transmit optical signals to the hollow-core optical fiber, and is a multimode optical fiber;

[0087] The hollow-core optical fiber has a tubular structure, the inner wall of the hollow-core optical fiber is coated with an inner metal film, the core of the hollow-core optical fiber is filled with alcohol, the outer wall of the hollow-core optical fiber is coated with an outer metal film, and an antibody is fixed outside the outer wall metal film film; the hollow-core optical fiber is used as a sensing area, and optical signals are transmitted in the tube wall of the hollow-core optical fiber;

[0088] The light-emitting optical fiber i...

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Abstract

A dual-parameter optical fiber sensor for biomolecules and temperature and its production method and application. The dual-parameter optical fiber sensor for biomolecules and temperature includes a light-incoming optical fiber, a hollow-core optical fiber, and a light-emitting optical fiber that are fused in sequence. Multimode optical fiber; the hollow-core optical fiber has a tubular structure, the inner wall of the hollow-core optical fiber is coated with an inner metal film, the core of the hollow-core optical fiber is filled with alcohol, the outer wall of the hollow-core optical fiber is coated with an outer metal film, and the outer metal film is sequentially deposited A charged polymer layer and an antibody film are immobilized. Its preparation adopts film coating, welding, and layer-by-layer deposition in sequence. The sensor solves the problem that biosensors are susceptible to temperature interference in the prior art, and at the same time can detect the temperature of the environment in which the biomolecules are located, so that it can not only avoid the interference of temperature on the detection results, but also avoid the detection of protein by measuring the temperature. spoiled.

Description

technical field [0001] The invention belongs to the field of optical fiber biosensing, in particular to an SPR biosensor, in particular to a dual-parameter optical fiber sensor of biomolecules and temperature, and a manufacturing method and application thereof. Background technique [0002] The principle of the surface plasmon resonance (SPR) sensor is: during the transmission of light, when total reflection occurs at the interface between two media, the light of a certain wavelength will resonate with the excited electronic wave in the metal film. Resonance causes light of a certain wavelength to be absorbed, so an absorption peak is formed. When the refractive index of the external environment to be measured in contact with the metal film changes, the position of the absorption peak generated by SPR will move accordingly, which is the basic principle of the SPR sensor. SPR sensor is a new type of biochemical sensing technology, which has the advantages of high sensitivity...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01D21/02G01K11/32G01N21/552
CPCG01D21/02G01K11/3206G01N21/553
Inventor 程同蕾周雪李雪刚李曙光闫欣
Owner NORTHEASTERN UNIV LIAONING
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