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Efficient moisturizing degradable drug sustained-release patch and preparation method thereof

A slow-release patch and drug technology, applied in the field of medicine, can solve the problems of inconvenient use, difficulty in controlling the dosage per unit area, and low patient acceptance, and achieve the effect of improving the yield rate

Pending Publication Date: 2020-04-14
苏州纳美特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complexity in the use of these preparations, such as the need for fresh preparation, the difficulty in grasping the dosage per unit area, the need for film packaging, etc., it is inconvenient to use; leading to low patient acceptance

Method used

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  • Efficient moisturizing degradable drug sustained-release patch and preparation method thereof
  • Efficient moisturizing degradable drug sustained-release patch and preparation method thereof
  • Efficient moisturizing degradable drug sustained-release patch and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] Example 1: An efficient moisturizing and degradable drug sustained-release patch and its preparation method, comprising a moisturizing layer 1, a medicinal layer 2 and an adhesive layer 3. The moisturizing layer 1 is provided with a depression in the middle, and the surrounding edges The adhesive layer 3 is adhered and fixed, and the recessed area of ​​the moisturizing layer 1 and the adhesive layer 3 form a hollow cavity, and the hollow cavity is filled with a drug layer 2;

[0031] The drug sustained-release patch is prepared by the following steps:

[0032] S1, coating a layer of adhesive layer 3 in the cavity of the mold, and then coating a layer of moisture-retaining layer 1 on the adhesive layer 3;

[0033] S2, press the adhesive layer 3 and the moisturizing layer 1 around, and leave an opening;

[0034] S3. Fill powder between the adhesive layer 3 and the moisturizing layer 1 through the opening, so that the adhesive layer 3 is completely attached to the inner wall of th...

Embodiment 2

[0044] Example 2: An efficient moisturizing and degradable drug sustained-release patch and its preparation method, comprising a moisturizing layer 1, a medicinal layer 2, and an adhesive layer 3. The moisturizing layer 1 is provided with a depression in the middle, and the surrounding edges The adhesive layer 3 is adhered and fixed, and the recessed area of ​​the moisturizing layer 1 and the adhesive layer 3 form a hollow cavity, and the hollow cavity is filled with a drug layer 2;

[0045] The drug sustained-release patch is prepared by the following steps:

[0046] S1, coating a layer of adhesive layer 3 in the cavity of the mold, and then coating a layer of moisture-retaining layer 1 on the adhesive layer 3;

[0047] S2, press the adhesive layer 3 and the moisturizing layer 1 around, and leave an opening;

[0048] S3. Fill powder between the adhesive layer 3 and the moisturizing layer 1 through the opening, so that the adhesive layer 3 is completely attached to the inner wall of t...

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Abstract

The invention discloses an efficient moisturizing degradable drug sustained-release patch and a preparation method thereof. The patch comprises a moisturizing layer, a medicament layer and an adhesivelayer. A concave area is arranged in the middle of the moisturizing layer, and the peripheral edges are attached and fixed to the adhesive layer. The concave area of the moisturizing layer and the adhesive layer form a hollow cavity, and the hollow cavity is filled with the medicament layer. The moisturizing layer is a water-soluble gel layer, the main component of the moisturizing layer is a pressure-sensitive adhesive, and the pressure-sensitive adhesive layer is one or more of an organic silicon pressure-sensitive adhesive, a polyacrylate pressure-sensitive adhesive and a polyurethane pressure-sensitive adhesive. The patch is directly attached to an oral infection part and matched with red and blue light irradiation when in use, and all drug effects of the photosensitizer in the medicament layer can be released within 2 hours to achieve a treatment effect on the infection part. The patch is efficient and convenient to use and can be widely applied to medical treatment.

Description

Technical field [0001] The invention relates to a high-efficiency moisturizing and degradable drug sustained-release patch and a preparation method thereof, and belongs to the technical field of medicine. Background technique [0002] After the domestic photosensitizer was successfully developed in 1981, Beijing Tongren Hospital was the first to use the drug to successfully treat the first case of skin cancer, setting a precedent for the clinical application of PDT in China. Afterwards, it has achieved remarkable results in the treatment of gastrointestinal mucosal microvascular disease, acne, port wine stains, condyloma acuminatum and other diseases (see Chinese Journal of Laser Medicine, 2012, 5, 278-307, application and clinical application of photodynamic therapy in China the study.). However, compared with therapies, the development of photodynamic drugs is seriously lagging behind. High-efficiency, low-toxicity photosensitizers and reasonable pharmaceutical preparations ar...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K41/00A61P31/04
CPCA61K9/006A61K41/0057A61P31/04A61K9/70A61K41/0061
Inventor 陈成胡勇曹金鑫顾惠龙
Owner 苏州纳美特生物科技有限公司
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