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Boysenberry, apple, and blackcurrant compositions and methods of preparation and use therefor

A composition, apple technology, applied in the directions of drug combinations, active ingredients of hydroxy compounds, applications, etc., can solve the problems of unclear role of pulmonary fibrosis remodeling, unsuccessful prevention of airway remodeling, etc.

Pending Publication Date: 2020-04-10
奥黛特 M 肖 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of polyphenol-rich fruits on lung fibrosis and tissue remodeling is unclear
To date, there is no successful way to prevent airway remodeling

Method used

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  • Boysenberry, apple, and blackcurrant compositions and methods of preparation and use therefor
  • Boysenberry, apple, and blackcurrant compositions and methods of preparation and use therefor
  • Boysenberry, apple, and blackcurrant compositions and methods of preparation and use therefor

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0207] Example 1: OVA-Induced Chronic Airway Inflammation and Boysenberry Oral Treatment

[0208] overview

[0209] Pulmonary fibrosis in chronic asthma negatively affects lung function and is associated with the development of a desmoplastic macrophage phenotype. Epidemiological studies have found that taking more fruits rich in phenols is beneficial to lung function. However, previous studies have not investigated the Boysenberry composition or its effects on fibrosis or remodeling in the airway system.

[0210] The inventors investigated the role of Boysenberry ingestion in therapeutic and prophylactic treatment strategies in a mouse model of antigen-induced chronic airway inflammation. Ingestion of Boysenberry reduces collagen deposition and improves tissue remodeling, along with an increase in CD68+CD206+arginase-activated macrophages in lung tissue. Reduced tissue remodeling was associated with increased expression of fibrinolytic matrix metalloproteinase-9 protein in...

example 2

[0262] Example 2: OVA-Induced Acute Airway Inflammation and Oral Treatment with Boysenberry and Apple

[0263] Materials and methods

[0264] Six week old mice were treated and evaluated in the manner of Example 1 as described above with the following modifications. The test solution included: Boysenberry 1 and Boysenberry 10 (0.67% and 6.7%, respectively), Apple 1 and Apple 10 (1.87% and 18.7%, respectively), BerriQi TM Boysenberry with Apple 1 and BerriQi TM Boysenberry vs Apple 10 (0.67% / 1.87% and 6.7% / 18.7%, respectively). A commercially available Boysenberry juice concentrate was obtained as described in Example 1. Apple juice concentrate was supplied by Infruit Ltd (Titirangi, Auckland, New Zealand) and manufactured by Profruit (2006) Ltd (Hastings, New Zealand).

[0265] For this 18.7% solution, 18.7 g of fruit juice concentrate were diluted in 100 g of water. For this 6.7% solution, 6.7 g of fruit juice concentrate were diluted in 100 g of water. For this 1.87% s...

example 3

[0282] Example 3: Overview of OVA-Induced Chronic Airway Inflammation and Oral Therapy with Boysenberry and Apple

[0283] While the beneficial health effects of the consumption of certain fruits and vegetables have been studied (87, 88, 91-94), the experiments described here show for the first time that specific Boysenberry compositions have significant beneficial effects. See Example 1 and Example 2, and (74). Key findings from the study in Example 1 include: 1) Boysenberry ingestion significantly attenuated allergen-induced airway inflammation by reducing cell infiltration and increasing anti-inflammatory protein production; development of cells (a type of immune cell), reduced collagen deposition and aided repair of damaged tissues; 3) Boysenberry treatment prevented ovalbumin (OVA)-induced airway inflammation.

[0284] The effect of different apple cultivars on key cytokines in allergic airway disease was also investigated (96), and the cytokine suppressive capacity of d...

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PUM

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Abstract

The present disclosure encompasses compositions prepared from Boysenberry and apple, as well as compositions prepared from Boysenberry, apple and blackcurrant. Also encompassed are methods of preparing these compositions and methods of using these compositions, in particular, for treating or preventing disorders of the respiratory system, including amongst others: inflammation, asthma, chronic obstructive pulmonary disease, allergic airways inflammation, reactive airway disease, airway fibrosis, and airway remodelling.

Description

[0001] related applications [0002] This application claims priority to New Zealand Patent Application No. 734440, filed 8 August 2017, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure relates to compositions made from Boysenberries and apples, and compositions made from Boysenberries, apples and black currants. The present disclosure also relates to methods of making such compositions, and methods of using such compositions, including the treatment or prevention of respiratory disorders, such as inflammatory conditions of the respiratory tract, including asthma, chronic obstructive pulmonary disease, allergic airway inflammation, reactions airway disease, airway fibrosis, airway remodeling, and the physiological conditions that lead to these conditions). Background technique [0004] Airway remodeling is understood as the progressive and irreversible decline in airway function due to structural changes in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K36/185A61K31/05A23L2/02A61P11/00
CPCA61K36/73A61K36/185A61K31/352A61P11/00A61P11/06A61K2300/00A23L33/10A23L33/105A23L33/30A23L2/02A61K31/05A23V2002/00A23V2200/314A23L29/035A61K45/06
Inventor 奥黛特·M·肖罗杰·D·赫斯特
Owner 奥黛特 M 肖
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