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Application of amino acid nutrient, and pharmaceutical composition comprising amino acid nutrient

A technology of amino acids and nutrients, applied in the device containing the composition, in the field of local pharmaceutical compositions for the treatment of local lesions, to achieve the effects of low local irritation, large intervention range, and high efficacy of local lesions

Pending Publication Date: 2020-03-10
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, there is still a need to develop new drugs for the treatment of local disease such as solid tumors, especially local drugs, to meet various clinical needs that cannot be met by existing technologies

Method used

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  • Application of amino acid nutrient, and pharmaceutical composition comprising amino acid nutrient
  • Application of amino acid nutrient, and pharmaceutical composition comprising amino acid nutrient
  • Application of amino acid nutrient, and pharmaceutical composition comprising amino acid nutrient

Examples

Experimental program
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Effect test

preparation example Construction

[0093] According to the preparation method of the present invention, the preparation of the pharmaceutical composition of the present invention comprises the following steps: preparing a liquid medicine containing the topical active ingredient, a liquid medium and other substances optionally present. The liquid medicament may be a solution (eg, in a hydrophilic vehicle, preferably an aqueous solution), a suspension, or an emulsion containing the topically active ingredient. When the liquid drug is a suspension, the dispersion medium therein can be any suitable one known to those skilled in the art, such as micro-materials or nano-materials. When the liquid drug is an emulsion, the dispersion medium therein can be any suitable one known to those skilled in the art, such as vegetable oil, synthetic oil or semi-synthetic oil that can be used for injection. Wherein said vegetable oil may be, for example, cottonseed oil, almond oil, olive oil, castor oil, sesame oil, soybean oil an...

Embodiment 1

[0169] Example 1: Optimal technical scheme for the application of amino acid nutrients

[0170] In the prior art, there are reports that amino acid nutrients may be beneficial for tumor nutrition. Therefore, the anti-tumor effect of amino acid nutrients is difficult to predict. It may inhibit tumor, may not inhibit tumor, or may help tumor. Through the following experiments, an application technical solution is optimized.

[0171] 1. Pharmacological optimization

[0172] In this study, the successfully modeled experimental animals (nude mice bearing pancreatic cancer cells PANC-1, with an average tumor volume of 105mm 3 ) were randomly divided into 2 negative control groups and 14 research groups. The negative control was normal saline, and the seven research drugs were shown in the table below, and they were injected intraperitoneally and intratumorally respectively. The medicines are all aqueous solutions, which are prepared according to the preparation method of Example...

Embodiment 2

[0194] Example 2: Other Uses of Amino Acid Nutrients as Topical Active Ingredients

[0195] One of the core features of tumors is heterogeneity. The following experiments investigated the use of amino acid-like nutrients as topical active ingredients for a variety of tumors. In the following experiments, successfully modeled nude mice bearing human tumor cells were randomly divided into 1 negative control group and 4 study groups (groups A, B, C, and D), and the corresponding negative controls were normal saline, The four research drugs were: 20% arginine, 3% glutamate hydrochloride, 10% alanyl-glutamine, and 10% glutathione. All groups were given intratumoral injection, once every 3 days, a total of 3 times, 100 μl per mouse. On the next day after the end of the medication, the animals were euthanized, and the tumor weight was measured after dissection, and the tumor inhibition rate was calculated from the respective negative control groups.

[0196] 1) Application in the ...

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PUM

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Abstract

The present application discloses an application of an amino acid nutrient in preparing a local pharmaceutical composition for treating local lesion diseases, the local pharmaceutical composition comprising the amino acid nutrient and a synergist of the amino acid nutrient for treating local lesion diseases, and a device comprising the composition.

Description

technical field [0001] The disclosure of this application relates to the application of amino acid nutrients in the preparation of topical pharmaceutical compositions for treating local lesions, the topical pharmaceutical compositions for treating local lesions containing the amino acid nutrients and their synergists, and the compositions containing the same device. Background technique [0002] Solid tumors are often used as a model for studies of localized disease, especially refractory localized disease, as supported by extensive research work. A solid tumor is a tumor disease with tumor symptoms, which is a characteristic diseased tissue containing tumor cells. Taking pancreatic cancer tumors as an example, pancreatic cancer cells only account for about 30% of the tumor volume. It can be seen that in addition to tumor cells, there are often a large number of other components (sometimes also called the microenvironment of tumor cells) in tumor tissues, including other t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/19A61P35/00A61P29/00A61P5/00A61P17/00A61K31/185A61K31/197A61K31/198A61K31/405A61K31/4172
CPCA61K45/00A61P35/00A61P29/00A61P5/00A61P17/00A61K31/198A61K31/405A61K31/4172A61K31/185A61K31/197A61K9/19A61P1/16A61K9/0019A61K47/12A61K47/183A61K9/0014A61K45/06A61K38/063A61K31/513A61K31/675A61K31/704A61K47/10A61K47/26A61K47/186A61K47/38A61K9/0043A61K2300/00A61K31/401A61K38/00A61K9/08
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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