Application of amino acid nutrient, and pharmaceutical composition comprising amino acid nutrient
A technology of amino acids and nutrients, applied in the device containing the composition, in the field of local pharmaceutical compositions for the treatment of local lesions, to achieve the effects of low local irritation, large intervention range, and high efficacy of local lesions
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[0093] According to the preparation method of the present invention, the preparation of the pharmaceutical composition of the present invention comprises the following steps: preparing a liquid medicine containing the topical active ingredient, a liquid medium and other substances optionally present. The liquid medicament may be a solution (eg, in a hydrophilic vehicle, preferably an aqueous solution), a suspension, or an emulsion containing the topically active ingredient. When the liquid drug is a suspension, the dispersion medium therein can be any suitable one known to those skilled in the art, such as micro-materials or nano-materials. When the liquid drug is an emulsion, the dispersion medium therein can be any suitable one known to those skilled in the art, such as vegetable oil, synthetic oil or semi-synthetic oil that can be used for injection. Wherein said vegetable oil may be, for example, cottonseed oil, almond oil, olive oil, castor oil, sesame oil, soybean oil an...
Embodiment 1
[0169] Example 1: Optimal technical scheme for the application of amino acid nutrients
[0170] In the prior art, there are reports that amino acid nutrients may be beneficial for tumor nutrition. Therefore, the anti-tumor effect of amino acid nutrients is difficult to predict. It may inhibit tumor, may not inhibit tumor, or may help tumor. Through the following experiments, an application technical solution is optimized.
[0171] 1. Pharmacological optimization
[0172] In this study, the successfully modeled experimental animals (nude mice bearing pancreatic cancer cells PANC-1, with an average tumor volume of 105mm 3 ) were randomly divided into 2 negative control groups and 14 research groups. The negative control was normal saline, and the seven research drugs were shown in the table below, and they were injected intraperitoneally and intratumorally respectively. The medicines are all aqueous solutions, which are prepared according to the preparation method of Example...
Embodiment 2
[0194] Example 2: Other Uses of Amino Acid Nutrients as Topical Active Ingredients
[0195] One of the core features of tumors is heterogeneity. The following experiments investigated the use of amino acid-like nutrients as topical active ingredients for a variety of tumors. In the following experiments, successfully modeled nude mice bearing human tumor cells were randomly divided into 1 negative control group and 4 study groups (groups A, B, C, and D), and the corresponding negative controls were normal saline, The four research drugs were: 20% arginine, 3% glutamate hydrochloride, 10% alanyl-glutamine, and 10% glutathione. All groups were given intratumoral injection, once every 3 days, a total of 3 times, 100 μl per mouse. On the next day after the end of the medication, the animals were euthanized, and the tumor weight was measured after dissection, and the tumor inhibition rate was calculated from the respective negative control groups.
[0196] 1) Application in the ...
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