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Pharmaceutical composition containing carbohydrate nutrient and conventional ineffective compound and application of pharmaceutical composition

A nutrient and composition technology, applied to the device comprising the composition, the field of topical pharmaceutical compositions for the treatment of local pathological diseases, to achieve the effects of non-toxic systemic safety, low local irritation, and effective treatment

Pending Publication Date: 2020-03-10
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, there is still a need to develop new drugs for the treatment of local disease such as solid tumors, especially local drugs, to meet various clinical needs that cannot be met by existing technologies

Method used

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  • Pharmaceutical composition containing carbohydrate nutrient and conventional ineffective compound and application of pharmaceutical composition
  • Pharmaceutical composition containing carbohydrate nutrient and conventional ineffective compound and application of pharmaceutical composition
  • Pharmaceutical composition containing carbohydrate nutrient and conventional ineffective compound and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0090] According to the preparation method of the present invention, the preparation of the pharmaceutical composition of the present invention comprises the following steps: preparing a liquid medicine containing the topical active ingredient, a liquid medium and other substances optionally present. The liquid medicament may be a solution (eg, in a hydrophilic vehicle, preferably an aqueous solution), a suspension, or an emulsion containing the topically active ingredient. When the liquid drug is a suspension, the dispersion medium therein can be any suitable one known to those skilled in the art, such as micro-materials or nano-materials. When the liquid drug is an emulsion, the dispersion medium therein can be any suitable one known to those skilled in the art, such as vegetable oil, synthetic oil or semi-synthetic oil that can be used for injection. Wherein said vegetable oil may be, for example, cottonseed oil, almond oil, olive oil, castor oil, sesame oil, soybean oil an...

Embodiment 1

[0179] Embodiment 1: the preparation of composition of the present invention

[0180] According to the above preparation method of the composition of the present invention, many different compositions of the present invention can be prepared. The compositions of some compositions of the present invention prepared in this example are listed in Table 2.

[0181] Table 2

[0182]

[0183]

[0184] Several examples of preparation tests of the compositions of the present invention are listed below.

[0185] 1. Preparation of liquid injection (1)

[0186] Measure glyconutrients (such as 30g glucose), conventional invalid compounds (such as 10g glutathione), optional other components and dilute to total volume (such as 100ml) according to the required concentration (as described in Table 2). ) solvent (such as water for injection), and they are slowly mixed evenly, and after sterilizing and filtering, they are subpackaged into required quantities (such as 10ml / bottle) and sto...

Embodiment 2

[0199] Embodiment 2: Composition synergistic technical scheme is preferred

[0200] 1. Synergistic pharmacological optimization

[0201] In this research experiment, the successfully modeled experimental animals (bearing S180 mice, with an average tumor volume of 115mm 3) were randomly divided into 2 negative control groups and 32 research groups. The negative control was physiological saline, and the 16 research drugs were shown in the table below, and they were injected intraperitoneally and intratumorally respectively. The medicines are all aqueous solutions, which are prepared according to the preparation method of Example 1. Medicate once every 3 days, a total of 3 times, each time 115μl / only. The animals were euthanized on the next day after the administration, and the tumor weight was measured after dissection, and the tumor inhibition rate was calculated from the respective negative control groups. The results are shown in Table 3.

[0202] table 3

[0203] ...

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Abstract

The present application discloses an application of a carbohydrate nutrient as a local active ingredient in preparing a local pharmaceutical composition for treating local lesion diseases, the local pharmaceutical composition containing the carbohydrate nutrient as a local active ingredient and a conventional ineffective compound, and a device comprising the composition.

Description

technical field [0001] The present disclosure relates to the use of a glyconutrient as a topical active ingredient for the preparation of a topical pharmaceutical composition for the treatment of localized disease, a topical pharmaceutical combination for the treatment of a localized disease comprising the said glyconutrient as a topically active ingredient and a conventionally inactive compound objects, and devices comprising the composition. Background technique [0002] Solid tumors are often used as a model for studies of localized disease, especially refractory localized disease, as supported by extensive research work. A solid tumor is a tumor disease with tumor symptoms, which is a characteristic diseased tissue containing tumor cells. Taking pancreatic cancer tumors as an example, pancreatic cancer cells only account for about 30% of the tumor volume. It can be seen that in addition to tumor cells, there are often a large number of other components (sometimes also ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61K31/7016A61K31/702A61K31/7008A61K31/191A61K31/047A61K31/715A61P35/00A61P29/00A61P5/14A61P5/16A61P17/00A61M11/00
CPCA61K31/7004A61K31/7016A61K31/702A61K31/7008A61K31/191A61K31/047A61K31/715A61P35/00A61P29/00A61P5/14A61P5/16A61P17/00A61M11/00A61K2300/00
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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