A bionic three-phase tissue engineering scaffold

Abstract

The application discloses a bionic three-phase tissue engineering scaffold, which includes a plurality of scaffold layers, and the scaffold layers are stacked longitudinally, and the scaffold layers include bone scaffolds, cartilage scaffolds and tendon The scaffolds are at least partially abutted against each other, the cartilage scaffolds of adjacent layers are at least partially abutted against each other, and the tendon scaffolds of adjacent layers are at least partially abutted against each other, wherein the bone scaffolds, cartilage scaffolds and tendon scaffolds in at least two scaffold layers account for The location and / or scale of the regions are different. The above scheme controls the position and / or ratio of the area occupied by the bone scaffold, cartilage scaffold and tendon scaffold in each scaffold layer, so that the engineering scaffold obtained by superimposing each scaffold layer has bionic characteristics, and can be used according to the bone scaffold, cartilage scaffold in the actual tissue. The position and / or ratio of the scaffold and tendon scaffold are constructed so that it has a relatively normal tissue shape, rather than a simple flat structure, which is more in line with the physiological structure of the human body.

Description

technical field [0001] The invention mainly relates to the defect repair technology of the joint of bone and tendon, and in particular relates to a bionic three-phase tissue engineering scaffold and a construction method thereof. Background technique [0002] The following content is only the inventor's knowledge of the relevant technical field, and does not necessarily constitute prior art. [0003] The emergence and vigorous development of tissue engineering technology has encouraged clinicians and researchers to try to solve this problem through tissue engineering strategies. The traditional bone-tendon interface regeneration strategy of tissue engineering has the following problems: 1) Existing scaffolds are only biomimetic designed from one or two aspects of morphological structure, gradient mineralization, and mechanical properties, and lack multiple biomimetic properties; 2) Existing scaffolds Most of them are made of artificial synthetic materials, and lack the char...

AI Technical Summary

Problems solved by technology

The traditional bone-tendon interface regeneration strategy of tissue engineering has the following problems: 1) Existing scaffolds are only biomimetic designed from one or two aspects of morphological structure, gradient mineralization, and mechanical properties, and lack multiple biomimetic properties; 2) Existing scaffolds Most of them are made of artificial synthetic materials, and lack the characteristics of stem cell-directed differentiation induction in different areas of bone, fibrocartilage and tendon of the scaffold; 3) The introduction of exogenous seed cells has the risk of tumorigenesis, and the seed cells are loaded on the scaffold in vitro, The operation process of constructing tissue engineered grafts is cumbersome and difficult to preserve

However, the existing tissue engineering scaffolds do not consider how to simulate the normal bone-cartilage-tendon three-phase structure of the bone-tendon interface, resulting in the lack of dual bionic properties of normal tissue morphology and tensile mechanical properties of the existing scaffolds

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