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Novel pharmaceutical use of Tanreqing

A technology of phlegm heat clearing and medicine, applied in the direction of drug delivery, drug combination, medical preparations containing active ingredients, etc., can solve the problems of no psoriasis treatment, etc., to delay the progression of the disease, provide excellent relief, and reduce severity degree of effect

Pending Publication Date: 2020-02-28
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Tanreqing Injection is a compound preparation of pure traditional Chinese medicine whose main function is to clear away heat and detoxify. So far, there is no relevant report on the use of this preparation in the treatment of psoriasis

Method used

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  • Novel pharmaceutical use of Tanreqing
  • Novel pharmaceutical use of Tanreqing
  • Novel pharmaceutical use of Tanreqing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1. Effect and mechanism of Tanreqing injection on imiquimod-induced mouse skin psoriasis-like model

[0021] 1 Materials and methods

[0022] 1.1 Animals: Balb / c mice aged 8-11 weeks, half male and half male, SPF grade, weighing between 18-22g, raised under specific pathogen-free conditions, and provided with water and food at any time.

[0023] 1.2 Drugs: Imiquimod Cream (Mingxin Lidi, for external use, 0.25g / bag, 4 bags / box, produced by Sichuan Mingxin Pharmaceutical Co., Ltd.); Yaozhizi z20053138); Tanreqing injection (10ml / bottle, Shanghai Kaibao Pharmaceutical Co., Ltd., Guoyao Zhunzi Z20030054); TNF-α, IL-12, IL-17, IL-23 ELISA kits were purchased from Shanghai Hushang Biotechnology Co., Ltd.

[0024] 1.3 Modeling method: After the newly purchased Balb / c mice were acclimatized for one week, the hair in an area of ​​about 2 cm × 3 cm was shaved on the back of each mouse with a shaver, and the remaining hair in the area was completely removed with a depila...

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Abstract

The invention discloses a novel pharmaceutical use of a Tanreqing preparation. The use refers to application of the Tanreqing preparation in the preparation of drugs for preventing and / or treating psoriasis. Experiments show that the Tanreqing preparation can effectively decelerate the progression of imiquimod-induced illness of a mouse psoriasis model, reduce the severity of skin lesions at the peak, inhibit excessive proliferation of epidermal spinous cells and reduce expression of cytokines TNF-alpha, IL-17 and IL-23 in serum, has a good curative effect on the psoriasis, and has better alleviation effect than compound kuh-seng itching relief ointments and four-mixed liquid in terms of some indicators of the skin lesions caused by the psoriasis.

Description

technical field [0001] The invention relates to a new medicine application of Tanreqing. Background technique [0002] Psoriasis, commonly known as "psoriasis", is called "white rash" in traditional Chinese medicine. It is a chronic skin disease mainly manifested by erythema, papules, and scale damage. shape, so it is called "white worm". At present, there is no effective method to completely cure psoriasis clinically, and this disease has become one of the key diseases in dermatology research and prevention. The most widely used drugs in clinical psoriasis treatment are glucocorticoids, which have obvious curative effects, but long-term use can cause side effects such as skin atrophy, telangiectasia, folliculitis, and pigmentation. Long-term application of strong glucocorticoid preparations on a large area can cause systemic adverse reactions, and even induce pustular or erythrodermic psoriasis after drug withdrawal. [0003] Tanreqing Injection is a compound preparation...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/08A61P17/06A61K35/32A61K35/413
CPCA61K9/0019A61K9/08A61K35/32A61K35/413A61K36/355A61K36/539A61K36/634A61P17/06A61K2300/00
Inventor 王毅杨伟峰马淑骅李连达孙娅楠刘珏玲穆竟伟王国明刘宜善
Owner SHANGHAI KAIBAO PHARMA
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