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Multimodal molecular imaging strategy for radiation-induced brain injury biomarkers after nasopharyngeal carcinoma radiotherapy

A radiation brain injury and biomarker technology, applied in the field of medical detection, can solve the problems of unknown physiology and pathology of radiation brain injury

Active Publication Date: 2020-02-25
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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Problems solved by technology

However, the exact physiopathology of radiation brain injury remains unknown

Method used

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  • Multimodal molecular imaging strategy for radiation-induced brain injury biomarkers after nasopharyngeal carcinoma radiotherapy
  • Multimodal molecular imaging strategy for radiation-induced brain injury biomarkers after nasopharyngeal carcinoma radiotherapy
  • Multimodal molecular imaging strategy for radiation-induced brain injury biomarkers after nasopharyngeal carcinoma radiotherapy

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Embodiment Construction

[0026]This study included 77 patients (54 males and 23 females; aged between 25 and 59 years; mean age 45 years) with pathologically confirmed nasopharyngeal carcinoma and 67 normal controls. All patients received fractionated radiotherapy for the first time with three-dimensional conformal and intensity-adjusted techniques (total dose / fraction dose / exposure, 66-74Gy / 1.8-2.0Gy / 30-35 fractions). The patient was confirmed to be free of intracranial tumors or intracranial invasion prior to MRI examination. Patients with hypertension, diabetes, heart disease, intracerebral white matter degeneration, or vascular disease were excluded. The normal subjects constituted the control group, and the same exclusion criteria as the radical radiotherapy subjects were applied to the control group (ie, hypertension, diabetes, heart disease, intracerebral white matter degeneration, vascular lesions). Traditionally, definitive radiotherapy-induced neurological injury can be described as acute i...

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Abstract

The invention discloses a multimodal molecular imaging strategy for radiation-induced brain injury biomarkers after nasopharyngeal carcinoma radiotherapy, which specifically comprises the sequential steps of sample image acquisition, image analysis, brain segmentation, white matter fiber tract tracking, network construction and classification. It is discovered herein that a brain functional network connection mode may be used for monitoring dotting and for deciding thinking of functions according to the structure, and that the most reliable way to assess brain functions is to understand the anatomy of the brain and its underlying cerebral circuitry. Therefore, the study of the anatomical network between the white matter regions of the brain can supplement the understanding of the pathophysiological mechanism of radiation-induced brain injury, which is of great significance to exploring the neurological basis of cognitive dysfunction after radical radiotherapy.

Description

technical field [0001] The invention relates to the field of medical detection, in particular to a multimodal molecular imaging strategy for biomarkers of radiation brain injury after radiotherapy for nasopharyngeal carcinoma. Background technique [0002] Nasopharyngeal carcinoma is a common cancer with a high incidence of head and neck malignancies in southern China, and radical radiotherapy is the preferred treatment. However, radical radiotherapy may cause radiation brain injury, which is the most serious complication, and radiation brain injury can be roughly divided into three stages according to the time of occurrence: acute reaction period, early delayed radiation period, and late delayed radiation period. [0003] Damage later in the delayed radiation phase is usually irreversible. Cognitive impairment induced by radical radiotherapy significantly reduces the quality of life of patients with nasopharyngeal carcinoma. Radiation brain injury is most prominent in cog...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055
CPCA61B5/055A61B5/7267
Inventor 邱士军王宏琢冷西伍冬林熊炜烽
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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