Nuclear magnetic resonance method of two-dimensional J decomposition spectrum

A technology of nuclear magnetic resonance and coupling constant, which can be used in magnetic resonance measurement and other directions to solve problems such as signal crowding

Inactive Publication Date: 2020-02-14
XIAMEN UNIV
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  • Claims
  • Application Information

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Problems solved by technology

But due to the limited chemical shift range and signal splitting caused by scalar coupling, signal crowding and even overlapping are common in NMR spectra

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  • Nuclear magnetic resonance method of two-dimensional J decomposition spectrum
  • Nuclear magnetic resonance method of two-dimensional J decomposition spectrum
  • Nuclear magnetic resonance method of two-dimensional J decomposition spectrum

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Embodiment Construction

[0017] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0018] A kind of nuclear magnetic resonance method that is convenient to measure the two-dimensional J decomposition spectrum of coupling constant, comprises the following steps:

[0019] 1) collecting the NMR one-dimensional spectrum of the sample;

[0020] 2) Measure the pulse width of the 90-degree hard pulse of the sample;

[0021] 3) Set coherent selection gradient G 1 intensity and duration;

[0022] 4) Set the center position of the hydrogen nucleus to be studied as the center frequency of the selective 180-degree pulse, determine the pulse width of the selective 180-degree pulse according to the signal distribution, and measure the power of the selective pulse;

[0023] 5) Determine the indirect dimension spectrum width and indirect dimension sampling points ni, that is, the evolution time t 1 the number of increments;

[0024] 6) Use the measur...

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Abstract

The invention provides a nuclear magnetic resonance method of a two-dimensional J decomposition spectrum. The nuclear magnetic resonance method of the two-dimensional J decomposition spectrum is convenient for measuring a coupling constant. The method comprises the following steps of: firstly, applying a 90-degree hard pulse to rotate a magnetization vector from a Z direction to an XY plane; secondly, applying an improved spin echo module, namely inserting a selective 180-degree pulse into a conventional 't 1/2-180-degree-t 1/2' module; and finally, performing two-dimensional Fourier transformto obtain a two-dimensional spectrogram, wherein a signal separation mode arranged along 45 degrees in the conventional two-dimensional J decomposition spectrum is changed into two split signals arranged along 45 degrees, and the distance between the two signals is J coupling related to a kernel acted by the selective 180-degree pulse. The two-dimensional spectrum is rotated by 45 degrees and isprojected to a direct dimension to obtain a pure chemical displacement one-dimensional spectrum, but the J coupling related to the selected kernel is reserved. Therefore, the J coupling constant related to the selected kernel can be conveniently measured from a direct dimension projection spectrum.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance method, in particular to a nuclear magnetic resonance method for conveniently measuring a two-dimensional J decomposition spectrum of a coupling constant. Background technique [0002] NMR spectroscopy is a noninvasive and widely used analytical tool. J-coupling is an important parameter in NMR spectroscopy, which can provide valuable information about molecular structure and conformation. The J-coupling constant can be measured from the signal splitting of the 1D spectrum. But signal crowding and even overlapping are common in NMR spectra due to the limited chemical shift range and signal splitting caused by scalar coupling. Two-dimensional J-decomposition spectroscopy can separate chemical shift and J-coupling into two dimensions, which greatly reduces signal crowding and facilitates the measurement of J-coupling constants. Later, many methods dedicated to the measurement of J coupling constant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/36
CPCG01R33/36
Inventor 林雁勤曾庆陈金永陈忠
Owner XIAMEN UNIV
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