Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of osteopontin in hypoxic-ischemic brain injury

A technology for hypoxia, ischemia and brain injury, applied in the fields of biomedicine and molecular biology, which can solve problems such as unclear effects and underlying mechanisms

Active Publication Date: 2022-02-11
SHANDONG UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the role and underlying mechanisms of OPN in hypoxic-ischemic brain injury are unclear

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of osteopontin in hypoxic-ischemic brain injury
  • Application of osteopontin in hypoxic-ischemic brain injury
  • Application of osteopontin in hypoxic-ischemic brain injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085]1. Establishment and grouping of animal models: C57BL / 6J mice were purchased from the Experimental Animal Center of Shandong University after 15 days of pregnancy, and were raised under standardized environmental conditions. The animal research was approved by the Animal Ethics and Welfare Committee of Shandong University. On the 7th day after the birth of the mouse, the HI brain injury model was established. In short, the skin was cut along the middle right of the neck to expose and the right common carotid artery of the mouse was ligated, and the mouse was put back into the mouse cage to rest for 1 hour , and then the mice were placed in an anoxic box with 8% oxygen and 92% nitrogen for 1.5 hours.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides the application of osteopontin in hypoxic-ischemic brain injury, and belongs to the technical fields of biomedicine and molecular biology. The present invention uses proteomics to find that the change of osteopontin is the most obvious in the damaged cortex of HI neonatal mice, and further tests prove that osteopontin may be the link between peripheral macrophage invasion and neuroinflammation in the hypoxic-ischemic brain injury. It is a potential target of the vicious cycle, which proves that osteopontin can be used as a diagnostic and prognostic marker and a potential therapeutic target in hypoxic-ischemic brain injury, so it has good practical application value.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and molecular biology, and specifically relates to the application of osteopontin in hypoxic-ischemic brain injury. Background technique [0002] The information disclosed in the Background of the Invention is only intended to increase the understanding of the general background of the invention, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes the prior art that is already known to those skilled in the art. [0003] Perinatal hypoxic-ischemic (HI) brain injury is fetal and neonatal brain injury caused by perinatal hypoxic-ischemic, which can lead to the destruction of brain metabolism and function, and abnormal cerebral blood flow. , vascular leakage, tissue damage and necrosis and corresponding inflammatory changes, energy failure after ischemia, abnormal maintenance of ion gradient, accumulation of lactic acid, increased pro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G01N33/68A61K45/00A61K39/395A61P9/10A61P25/00
CPCC12Q1/6883G01N33/6863G01N33/6893A61K45/00C07K16/24A61P9/10A61P25/00C12Q2600/158C12Q2600/118G01N2800/2871G01N2800/52A61K2039/505
Inventor 王贞李婷婷刘德祥柯鸿飞
Owner SHANDONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com