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Application of osteopontin to hypoxic ischemic brain damage

A technology of hypoxia-ischemia and osteopontin, which is applied in the fields of biomedicine and molecular biology, and can solve problems such as unclear effects and underlying mechanisms

Active Publication Date: 2020-02-11
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the role and underlying mechanisms of OPN in hypoxic-ischemic brain injury are unclear

Method used

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  • Application of osteopontin to hypoxic ischemic brain damage
  • Application of osteopontin to hypoxic ischemic brain damage
  • Application of osteopontin to hypoxic ischemic brain damage

Examples

Experimental program
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Embodiment 1

[0085]1. Establishment and grouping of animal models: C57BL / 6J mice were purchased from the Experimental Animal Center of Shandong University after 15 days of pregnancy, and were raised under standardized environmental conditions. The animal research was approved by the Animal Ethics and Welfare Committee of Shandong University. On the 7th day after the birth of the mouse, the HI brain injury model was established. In short, the skin was cut along the middle right of the neck to expose and the right common carotid artery of the mouse was ligated, and the mouse was put back into the mouse cage to rest for 1 hour , and then the mice were placed in an anoxic box with 8% oxygen and 92% nitrogen for 1.5 hours.

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Abstract

The invention provides an application of osteopontin to hypoxic ischemic brain damage, and belongs to the technical field of biological pharmaceuticals and molecular biology. Through proteomics, the inventor of the invention finds that osteopontin changes in damaged cortex of an HI newborn mouse are most obvious, further the experiment proves that the osteopontin is possibly a potential target point for restraining vicious circulation between peripheral macrophage invasion and neurogenic inflammation of the hypoxic ischemic brain damage, which proves that the osteopontin can be used as a marker for diagnosis and prognosis of the hypoxic ischemic brain damage and a potential treatment target point, so that the osteopontin has favorable practical application value.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and molecular biology, and specifically relates to the application of osteopontin in hypoxic-ischemic brain injury. Background technique [0002] The information disclosed in the Background of the Invention is only intended to increase the understanding of the general background of the invention, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes the prior art that is already known to those skilled in the art. [0003] Perinatal hypoxic-ischemic (HI) brain injury is fetal and neonatal brain injury caused by perinatal hypoxic-ischemic, which can lead to the destruction of brain metabolism and function, and abnormal cerebral blood flow. , vascular leakage, tissue damage and necrosis and corresponding inflammatory changes, energy failure after ischemia, abnormal maintenance of ion gradient, accumulation of lactic acid, increased pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/68A61K45/00A61K39/395A61P9/10A61P25/00
CPCC12Q1/6883G01N33/6863G01N33/6893A61K45/00C07K16/24A61P9/10A61P25/00C12Q2600/158C12Q2600/118G01N2800/2871G01N2800/52A61K2039/505
Inventor 王贞李婷婷刘德祥柯鸿飞
Owner SHANDONG UNIV
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