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An implantable ear cartilage composite support

A composite stent, implantable technology, applied in nose implants, medical science, prostheses, etc., can solve the problems of insufficient support, poor stability, poor hardness, etc., to improve stability, increase support, increase The effect of its own strength and hardness

Active Publication Date: 2021-10-12
朱伟伟 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the above technical solutions of the prior art, simply using cartilage tissue as a scaffold is prone to insufficient support strength, resulting in technical problems of low strength, poor hardness, and poor stability of the cartilage scaffold.

Method used

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  • An implantable ear cartilage composite support
  • An implantable ear cartilage composite support
  • An implantable ear cartilage composite support

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Such as Figure 1-4 As shown, an implantable ear cartilage composite bracket; includes a first bracket 1 and a second bracket 2; one end of the first bracket 1 and the second bracket 2 is connected with a connecting frame 3, and the first bracket 1 and the second bracket 2 are connected to each other. The second support 2 forms a "human" structure through the connection frame 3; the first support 1, the second support 2 and the connection frame 3 all include a line carving fiber core 4 and an ear cartilage support layer 5, and the line carving line The outside of the fiber core 4 is wrapped with an ear cartilage support layer 5 .

[0053] The thread-carving fiber core 4 has a helical structure. The acute angle included in the "human" shape of the first bracket 1 and the second bracket 2 ranges from 35° to 50°.

[0054] In addition, during the preparation of the ear cartilage scaffold, the removed ear cartilage tissue was minced, washed three times with phosphate hydro...

Embodiment 2

[0059] The preparation method of the implantable ear cartilage composite bracket comprises the following steps:

[0060] S1: Add the thread carving thread into the N,N-dimethylformamide solvent and stir it, after ultrasonic treatment, let it stand for a period of time, add alkaline solution to solidify, stretch while solidifying, wash, dry, and get the thread carving thread fiber Core 4;

[0061] S2: Take the hyaline ear cartilage tissue, cut it into pieces, add active agent and protease inhibitor for centrifugation, remove the supernatant, and keep the precipitated part of the solution;

[0062] S3: add active agent and protease inhibitor buffer solution to the precipitation solution obtained in S2, oscillate and mix well, and wash the precipitated part repeatedly after centrifugation to obtain cartilage particles for later use;

[0063] S4: spread the cartilage particles obtained in S3 evenly on a culture dish, and then vacuum freeze-dry them in a freeze dryer to obtain car...

Embodiment 3

[0072] The difference from Examples 1 and 2 is that in order to further increase the stability of the ear cartilage scaffold, the specific surface area A of the ear cartilage cell particles is 850-1920 cm 2 / gram; PH value is 7-8, to increase the adhesion of ear chondrocytes, and at the same time increase the contact area with the cross-linking agent, which is beneficial to the proliferation and growth of ear chondrocytes. The specific surface area A of the ear chondrocyte particles and the pH value satisfy: A·PH is greater than or equal to 5950 and less than or equal to 15360.

[0073] The cell content M of the extracellular matrix of the ear cartilage, the specific surface area A of the ear chondrocytes and the pH value satisfy the following relationship:

[0074] A=μ·(PH) 3 / M 1 / 2 ;

[0075] In the above formula, μ is the specific surface area coefficient, and the value range is 3.24-6.65; only numerical calculations are performed here.

[0076] In order to improve the...

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Abstract

The invention discloses an implantable ear cartilage composite bracket; it includes a first bracket and a second bracket; one end of the first bracket and the second bracket is connected with a connecting frame, and the first bracket and the second bracket are connected by The frame forms a "human" structure; the first frame, the second frame and the connecting frame all include a thread-carved fiber core and an ear cartilage frame layer, and the outside of the thread-carved fiber core is wrapped with an ear cartilage frame layer; the present invention The ear cartilage tissue is used as a support, and the center of the thread carving fiber core is implanted to increase the supporting force of the cartilage support, increase the strength and hardness of the ear cartilage support, and further improve the stability of the ear cartilage support; through the "human" set Type structure, straddling the nasal septum, increasing its mechanical properties and further increasing the stability of the cartilage support.

Description

technical field [0001] The invention belongs to the technical field of biomaterials used in medicine, and in particular relates to an implanted ear cartilage composite bracket. Background technique [0002] The clinical application of cartilage scaffolds is common in plastic surgery and orthopedics, but with the increase of applications, there are also many shortcomings. For example, in plastic surgery, ear cartilage is used to pad the tip of the nose by taking out the cartilage of the pinna and placing it on the tip of the nose. , to achieve the purpose of nose tip shaping. There are two main methods of ear cartilage pad pen tip, one is to build a nose tip bracket, and then lift the nose tip up, and the other is to make the ear cartilage into a shield shape, pad it under the skin of the nose tip, and reach the tip of the nose purpose of shaping. [0003] At present, ear cartilage scaffolds are used for support. Ear cartilage alone is not strong enough to support the nasal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/18
CPCA61F2/186A61F2/30756A61F2002/30108A61F2002/30764
Inventor 朱伟伟柳晓燕
Owner 朱伟伟
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