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Resveratrol-dietary fiber solid dispersion and preparation method thereof

A technology of solid dispersion and resveratrol, which is applied in the field of food processing, can solve the problems of no patent report of resveratrol solid dispersion, etc., and achieve the effects of easy promotion, improved anti-oxidation, and simple preparation method

Active Publication Date: 2020-02-04
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the carrier substances used in resveratrol solid dispersions are mostly chemically synthesized or chemically modified polymers, such as hydroxypropyl-β-cyclodextrin, poloxamer 188, polyethylene glycol 4000, etc. , there is no related patent report on resveratrol solid dispersion using natural dietary fiber as carrier

Method used

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  • Resveratrol-dietary fiber solid dispersion and preparation method thereof
  • Resveratrol-dietary fiber solid dispersion and preparation method thereof
  • Resveratrol-dietary fiber solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of resveratrol-corn soluble dietary fiber solid dispersion (Res-CSDF):

[0048] (1) Weigh 10 mg of resveratrol and 90 mg of corn soluble dietary fiber;

[0049] (2) Disperse the corn soluble dietary fiber in 5 mL of deionized water, and stir at 500 rpm for 5 minutes to obtain the corn soluble dietary fiber aqueous solution;

[0050] (3) dissolving resveratrol in 1mL ethanol solution to obtain resveratrol ethanol solution;

[0051] (4) Add resveratrol ethanol solution into corn soluble dietary fiber aqueous solution, stir at 500rpm for 5min, let it stand for 24h, freeze-dry (drying temperature is -80°C, drying time is 24h), to obtain resveratrol- Corn soluble dietary fiber solid dispersion (Res-CSDF).

[0052] (5) Analysis of resveratrol-corn soluble dietary fiber solid dispersion using Fourier transform infrared spectroscopy and X-ray diffraction, see figure 1 and figure 2 ;

[0053] (6) Determination of the water solubility and bioaccessibility of res...

Embodiment 2

[0055] Preparation of resveratrol-resistant starch solid dispersion (Res-RS):

[0056] (1) Weigh 10 mg of resveratrol and 90 mg of resistant starch;

[0057] (2) Disperse the resistant starch in 5 mL of deionized water, and stir at 500 rpm for 5 minutes to obtain a resistant starch mixture;

[0058] (3) dissolving resveratrol in 1mL ethanol solution to obtain resveratrol ethanol solution;

[0059] (4) Add the resveratrol ethanol solution into the resistant starch mixture, stir at 500rpm for 5min, let it stand for 24h, freeze-dry (the drying temperature is -80°C, and the drying time is 24h), and the resveratrol- Resistant starch solid dispersion (Res-RS).

[0060] (5) Analysis of resveratrol-resistant starch solid dispersion (Res-RS) using Fourier transform infrared spectroscopy and X-ray diffraction, see figure 1 and figure 2 ;

[0061] (6) Determination of the water solubility and bioaccessibility of resveratrol-resistant starch solid dispersion (Res-RS), the results ar...

Embodiment 3

[0063] Preparation of resveratrol-resistant dextrin solid dispersion (Res-RM):

[0064] (1) Weigh 10 mg of resveratrol and 90 mg of resistant dextrin;

[0065] (2) Disperse the resistant dextrin in 5 mL of deionized water, and stir at 500 rpm for 5 minutes to obtain an aqueous solution of resistant dextrin;

[0066] (3) dissolving resveratrol in 1mL ethanol solution to obtain resveratrol ethanol solution;

[0067] (4) Add the resveratrol ethanol solution into the resistant dextrin aqueous solution, stir at 500rpm for 5min, let it stand for 24h, and freeze-dry (drying temperature is -80°C, drying time is 24h), that is, resveratrol- Resistant dextrin solid dispersion (Res-RM).

[0068] (5) Analysis of resveratrol-resistant dextrin solid dispersion (Res-RM) using Fourier transform infrared spectroscopy and X-ray diffraction, see figure 1 and figure 2 ;

[0069] (6) Determination of the water solubility and bioaccessibility of resveratrol-resistant dextrin solid dispersion (...

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Abstract

The invention discloses a resveratrol-dietary fiber solid dispersion and a preparation method thereof. The preparation method comprises the steps of taking the components in parts by mass of 1-3 partsof resveratrol and 7-9 parts of dietary fibers, adding the dietary fibers to deionized water, and performing stirring to obtain dietary fiber mixed liquid; and enabling the resveratrol to dissolve inan ethanol solution to obtain a resveratrol ethanol solution; and adding the resveratrol ethanol solution to the dietary fiber mixed liquid, performing stirring, performing standing for 24h, and thenperforming freeze drying to obtain the resveratrol-dietary fiber solid dispersion. The resveratrol water solubility of the prepared resveratrol-dietary fiber solid dispersion is increased to 130-205[mu]g / mL from 30.84 [mu]g / mL, the resveratrol biology accessibility in the solid dispersion is increased to 52-55% from 20.97%, the application range of the resveratrol in foods is widened, and the defects that in the prior art, the resveratrol is low in water solubility and low in biological availability are overcome.

Description

Technical field [0001] The invention belongs to the technical field of food processing, and specifically relates to a resveratrol-dietary fiber solid dispersion and a preparation method thereof. Background technique [0002] Resveratrol (3,4′,5-trihydroxystilbene, Res) is a natural polyphenolic compound found in many plants such as grapes, blueberries, pomegranates, peanuts, and hellebores. Various studies have shown that resveratrol has anti-inflammatory, antioxidant, anti-cancer, heart-protective and other health benefits. However, resveratrol's poor water solubility and low bioavailability limit its application in food. [0003] In response to the low solubility of resveratrol in water, many studies have reported many delivery systems, such as nanoparticles, cyclodextrin inclusion complexes, emulsions, amorphous solid dispersions, etc. Among them, amorphous solid dispersions are more popular in the industry due to their obvious solubilization effect, relatively simple p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/21A23L33/105
CPCA23L33/21A23L33/105A23V2002/00A23V2200/30A23V2250/2132A23V2250/5118A23V2250/5114A23V2250/082A23V2300/10A23V2300/20
Inventor 贾承胜纪苏萍曹丹丹张晓鸣
Owner JIANGNAN UNIV
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