Synthesis method of bagasse xylan citrate-g-BMA with antitumor activity

Abstract

The invention discloses a synthesis method of bagasse xylan citrate-g-BMA (benzyl methacrylate) with antitumor activity. The synthesis method comprises the following steps: firstly, synthesizing bagasse xylan-g-BMA by taking bagasse xylan as a main raw material, benzyl methacrylate as a grafting monomer and potassium persulfate as an initiator; and then performing catalytic esterification reactionin ionic liquid chlorinated-1-allyl-3-methylimidazole (AmimCl) by taking citric acid as an esterifying agent and sodium hypophosphite monohydrate as an esterification catalyst to synthesize the bagasse xylan citrate-g-BMA. The bagasse xylan is subjected to grafting, esterification and composite modification and two bioactive groups are introduced, so the water solubility and the heat stability ofthe bagasse xylan are improved, the antitumor activity of the bagasse xylan is further enhanced, and a certain application prospect in the aspects of development of anti-cancer medicines and the likeis achieved.

Description

technical field [0001] The invention relates to the technical field of fine chemicals, in particular to a method for synthesizing anticancer active bagasse xylan citrate-g-BMA. Background technique [0002] In recent years, the incidence of cancer in my country has been increasing year by year, and curing cancer has become an important topic in the medical field. The source and molecular structure of xylan endow it with unique biological activities, such as immunomodulatory activity, anti-cancer, anti-HIV, etc., which provides the possibility for the application of xylan in the field of medicine. However, there is a strong hydrogen bond network in and between xylan molecules, which leads to poor water solubility and insufficient activity. Therefore, it is necessary to improve and improve the application performance of xylan through chemical modification. At present, more researches are on xylan single-modified derivatives, such as esterification derivatives, graft copolymer...

AI Technical Summary

Problems solved by technology

However, there is a strong hydrogen bond network in and between xylan molecules, poor water solubility, and insufficient activity. Therefore, it is necessary to improve and improve the application performance of xylan by chemical modification.

At present, more researches are on xylan single-modified derivatives, such as esterification derivatives, graft copolymerization derivatives, etc., and the scope of application has certain limitations, while the research on xylan composite modified derivatives is relatively limited. few

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