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Temperature-sensitive nasal liquid dressing and preparation method thereof

A liquid dressing, temperature-sensitive technology, applied in the directions of liquid delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc. Relieve nasal inflammation and allergic symptoms, with good safety and less irritating effects

Pending Publication Date: 2020-01-17
吉林省华恩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Disadvantages of unclear dosage, and nasal drops require patients to instill with their heads up. Due to the large volume of instilled droplets, it is easy to flow into the nasopharynx
[0006] In contrast, nasal liquid dressings (nasal sprays, etc.) can be accurately quantified, and the contact area between the droplets and the nasal mucosa is wider, and it is hygienic and convenient to use, but the retention capacity is weaker than that of gels

Method used

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  • Temperature-sensitive nasal liquid dressing and preparation method thereof
  • Temperature-sensitive nasal liquid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: a kind of temperature-sensitive nasal cavity liquid dressing

[0033] The preparation comprises the following components in mass percentage: 1% of glycerin, 40715% of poloxamer, 1882% of poloxamer, 1% of sodium carboxymethylcellulose, and the remaining components are purified water.

Embodiment 2

[0034] Embodiment 2: a kind of temperature-sensitive nasal cavity liquid dressing

[0035] The preparation includes the following components in mass percentage: 1% of glycerin, 40718% of poloxamer, 1881% of poloxamer, 1% of sodium carboxymethylcellulose, and the remaining components are purified water.

[0036] The preparation method of this preparation comprises the steps:

[0037] 1) Add glycerin and sodium carboxymethylcellulose to pure water under stirring, stir until uniformly dispersed, and cool at room temperature for later use;

[0038] 2) Weigh a certain amount of poloxamer 407 and poloxamer 188, slowly add the solution obtained in step 1), stir evenly and set aside;

[0039] 3) sterilizing the solution obtained in step 2);

[0040] 4) bottle the solution obtained in step 3).

[0041] The temperature-sensitive nasal cavity liquid dressing of the present invention is a transparent or nearly transparent liquid with a faint special smell and a pH value of 5.5-7.4. The...

Embodiment 3

[0042] Embodiment 3: Efficacy experiment carried out for the preparation obtained in embodiment 1 and embodiment 2

[0043] Experiment 1:

[0044] Subjects of the experiment: 22 males and females with different irritation symptoms of nasal mucosa were selected from people aged 20-70 years old.

[0045] Experimental method: Take the preparation provided in Example 1 and drop it on the nasal mucosa 3 to 5 times a day, 5 days as a course of treatment.

[0046] Efficacy criteria: 1. Cured: the symptoms of nasal mucosa irritation completely disappeared; 2. Significant effect: the symptoms of nasal mucosa irritation were significantly relieved; 3. Effective: the symptoms of nasal mucosa irritation were partially relieved; 3. Ineffective: no change before and after use.

[0047] The use effect is as follows:

[0048]

[0049]

[0050] Experiment 2:

[0051] Subjects of the experiment: 20-70 years old people, 33 males and females with different irritation symptoms of nasal...

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Abstract

The invention discloses a temperature-sensitive nasal liquid dressing and a preparation method thereof and mainly relates to the field of nasal medicine. The temperature-sensitive nasal liquid dressing comprises, by weight, 0.1-20 parts of glycerin, 1-20 parts of poloxamer 407, 0.1-5 parts of poloxamer 188, 0.2-5 parts of sodium carboxymethylcellulose and 1-99 parts of water. Sprayability of a solution and adhesiveness of gel are combined, so that ability of a preparation to retain in the nasal cavity is improved at the premise that administration of the liquid dressing is achieved; a physicalbarrier is formed in a nasal vestibule to block allergens to reduce the number of allergens in a nose, so that allergic symptoms are relieved.

Description

technical field [0001] The invention relates to the field of nasal medicine, in particular to a temperature-sensitive nasal liquid dressing and a preparation method. Background technique [0002] Pollen allergy is also called hay fever and hay fever. The diameter of pollen is generally about 30-50 μm, and they are easily inhaled by people into the respiratory tract. People with pollen allergies can experience allergic reactions when inhaled. In order to prevent pollen allergic reaction, you can use the method of blocking pollen allergens. [0003] Existing listed antiallergic nasal preparations mainly include nasal drops, nasal cavity spray and nasal gel, and nasal drops and nasal gel. They have many problems, such as: [0004] Contains preservatives which reduce the decongestant effect on the nasal mucous membranes. In addition, they frequently cause irritation of the nasal mucosa and damage the nasal cilia. [0005] The dosage is not clear, and the nasal drops require...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/10A61K47/26A61K47/38A61P11/02A61P37/08
CPCA61K9/06A61K9/0043A61K47/26A61K47/38A61K47/10A61P11/02A61P37/08
Inventor 李春江
Owner 吉林省华恩生物科技有限公司
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