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Application of Chaidamu agaricus bitorquis phenolic acid in protecting acute hypoxia injury and chronic hypoxia injury

A technology of hypoxic injury and phenolic acid of phyllocarpus, which is applied in the field of medicinal health products, to achieve the effect of prolonging survival time, prolonging wheezing time, and increasing the content level

Inactive Publication Date: 2020-01-10
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the anti-hypoxia effect of phenolic acid on Qaidam pratense mushroom

Method used

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  • Application of Chaidamu agaricus bitorquis phenolic acid in protecting acute hypoxia injury and chronic hypoxia injury
  • Application of Chaidamu agaricus bitorquis phenolic acid in protecting acute hypoxia injury and chronic hypoxia injury
  • Application of Chaidamu agaricus bitorquis phenolic acid in protecting acute hypoxia injury and chronic hypoxia injury

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with accompanying drawing by specific embodiment:

[0022] The Qaidam big fat mushroom phenolic acid used in the specific embodiment of the present invention is prepared by conventional phenolic acid extraction and purification methods, and the specific operations in the present invention are as follows:

[0023] 1. Preparation of Phenolic Acids from Chaidamu Phytophthora

[0024] 1) To remove sugar from Qaidam big fat mushroom: mix fruiting body powder and distilled water at a ratio of 1:20, keep at 70°C for 60 minutes, assist in ultrasonic extraction, suction filtration, and centrifugation to obtain residues, and discard the extract after filtering;

[0025] 2) Extraction of Phenolic Acids from Chaidamu Fatty Mushroom: Weighing the sugar-removed Qaidam Fatty Mushroom residue obtained in step 1) and mixing with 90% ethanol, ultrasonically assisted extraction, centrifugation to obtain the extract, and ...

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Abstract

The invention discloses application of Chaidamu agaricus bitorquis phenolic acid in the preparation of drugs, health products or food for protecting acute hypoxia injury and chronic hypoxia injury. The study of the application of the Chaidamu agaricus bitorquis phenolic acid in the preparation of the drugs, health products or food for protecting against acute hypoxia injury and chronic hypoxia injury shows that the Chaidamu agaricus bitorquis phenolic acid has the effects of prolonging death time of hypoxic mice in atmospheric pressure hypoxia-resistant test, prolonging urvival time of poisoned mice in sodium nitrite poisoning test and prolonging wheezing time of acute hypoxic mice in acute cerebral ischemic hypoxia test; the content levels of LDH (lactate dehydrogenase) and NO (carbon monoxide) can be reduced under the hypoxia conditions, the content level of ATP (adenosine triphosphate) is increased, the resistant ability of the hypoxia injury of a body is enhanced, and the compensation ability of the tissue for the acute hypoxia injury is improved; and the tissue is protected from hypoxia, and the Chaidamu agaricus bitorquis phenolic acid can be used as the safe and reliable anti-hypoxia drugs, health products or food.

Description

technical field [0001] The invention relates to the technical field of medicinal health care products, in particular to an anti-hypoxia application of phenolic acid of Qaidam pratense mushroom. [0002] technical background [0003] High altitude disease (HAD) is an idiopathic disease that occurs in high altitude hypoxic environments (generally above 3000m above sea level), and high altitude hypobaric hypoxia is the main pathogenic factor. Altitude sickness can be divided into acute mountain sickness (acute mountain sickness, AMS) and chronic mountain sickness (Chronic mountain sickness, CMS) according to the severity of onset. , various clinical syndromes occurring within hours to days, including acute mild altitude sickness, high altitude pulmonary edema, and high altitude cerebral edema; The clinical syndrome caused by gradual loss of acclimatization includes four subtypes: high-altitude polycythemia, high-altitude heart disease, mixed chronic high-altitude sickness, and ...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P39/00A61P43/00A23L31/00A23L33/10
CPCA23V2002/00A61K36/07A61K2236/333A61K2236/53A61K2236/55A23L31/00A23L33/10A61P39/00A61P43/00A23V2200/30A23V2250/21
Inventor 焦迎春陈雅楠
Owner QINGHAI UNIVERSITY
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