Valganciclovir composition

A technology of valganciclovir and valganciclovir hydrochloride, applied in the pharmaceutical field, can solve the problems of poor tableting effect, inconvenient storage, poor absorption effect and the like

Pending Publication Date: 2019-12-27
湖北科益药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies in the prior art, the present invention provides a valganciclovir composition, which solves the problem of poor absorption effect, affecting the performance of the drug, reducing the utilization rate of active ingredients, and poor tablet compression effect, easy to loose , the problem of inconvenient storage

Method used

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  • Valganciclovir composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] S1, sieving: pass valganciclovir hydrochloride through a 90-mesh sieve, and pass tomatine through a 120-mesh sieve;

[0029] S2. Adhesive preparation: Take an appropriate amount of cornstarch and put it into a mixer, then add an appropriate amount of cold water, stir at a speed of 600r / min to form a starch suspension, then heat it on a water bath at 85°C, and continue to stir to make a starch slurry as an adhesive Mixture spare;

[0030] S3, mixing: get 50 parts of sieved valganciclovir hydrochloride in S1 and put it into a blender, then add 3 parts of stabilizer, 15 parts of tomatine and 5 parts of filler, under normal temperature condition with 800r / Stir at a speed of 1 min for 5 min to mix the materials evenly, then add 3 parts of lactose, 2 parts of binder and 8 parts of sodium hydroxymethyl starch successively and continue stirring to obtain a material mixture, then add a wetting agent, and use a vacuum dryer at 30 Vacuum drying at ℃;

[0031] S4. Tablet compres...

Embodiment 2

[0033] S1, sieving: pass valganciclovir hydrochloride through a 93-mesh sieve, and pass tomatine through a 127-mesh sieve;

[0034] S2. Adhesive preparation: Take an appropriate amount of cornstarch and put it into a mixer, then add an appropriate amount of cold water, stir at a speed of 600r / min to form a starch suspension, then heat it on a water bath at 88°C, and continue to stir to make a starch slurry as an adhesive Mixture spare;

[0035] S3, mixing: get 60 parts of sieved valganciclovir hydrochloride in S1 and put it into a blender, then add 4 parts of stabilizer, 18 parts of tomatine and 6 parts of fillers, under normal temperature condition with 800r / Stir for 7 minutes at a speed of 1 min to mix the materials evenly, then add 4 parts of lactose, 3 parts of binder and 9 parts of sodium hydroxymethyl starch successively and continue stirring to obtain a material mixture, then add a wetting agent, and use a vacuum dryer to dry Vacuum drying at 30°C;

[0036]S4. Tablet...

Embodiment 3

[0038] S1, sieving: pass valganciclovir hydrochloride through a 98-mesh sieve, and pass tomatine through a 125-mesh sieve;

[0039] S2. Adhesive preparation: Take an appropriate amount of cornstarch and put it into a mixer, then add an appropriate amount of cold water, stir at a speed of 600r / min to form a starch suspension, then heat it on a water bath at 92°C, and continue stirring to make a starch slurry as a paste Mixture spare;

[0040] S3, mixing: get 70 parts of sieved valganciclovir hydrochloride in S1 and put it into a blender, then add 6 parts of stabilizers, 22 parts of tomatine and 7 parts of fillers, under normal temperature conditions with 800r / Stir at a speed of 8 min to mix the materials evenly, then add 5 parts of lactose, 4 parts of adhesives and 11 parts of sodium hydroxymethyl starch successively and continue stirring to obtain a material mixture, then add a wetting agent, and use a vacuum dryer to dry Vacuum drying at 30°C;

[0041] S4. Tablet compressi...

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Abstract

The invention discloses a valganciclovir composition which is prepared from the following raw materials in parts by weight:50 to 75 parts of valganciclovir hydrochlorides, 8 to 12 parts of sodium carboxymethyl starch, 5 to 8 parts of a filling agent, 3 to 6 parts of lactose, 15 to 25 parts of tomatin, 2 to 5 parts of a binding agent and 3 to 7 parts of a stabilizing agent. A preparation method ofthe valganciclovir composition comprises the following steps of Step 1, sieving, Step 2, bonding agent preparation, Step 3, material mixing, and Step 4, tableting. The valganciclovir composition relates to the technical field of pharmacy. A certain amount of tomatine is added into the valganciclovir composition; the tomatine can activate immune cells, can protect phagocytes from self oxidization injury, can promote the generation of some interleukin, can inhibit the generation of inflammatory mediators, and has the effect of improving the human body immunity; in addition, the tomatine is favorable for digestion; the absorption of the human body on taken medicine can be enhanced; and the utilization rate of active ingredients is improved. Through the addition of the bonding agent, the filling agent and the sodium carboxymethyl starch, the valganciclovir composition has a better tableting effect, cannot easily become loose, and is convenient to store.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a valganciclovir composition. Background technique [0002] Valganciclovir is a synthetic 2-deoxyguanosine analog, which is the prodrug of the antiviral drug ganciclovir, which can greatly reduce the toxicity of ganciclovir. Its pharmacodynamic characteristics are similar to those of ganciclovir. Similarly, after oral administration of valganciclovir, it is rapidly hydrolyzed into ganciclovir under the action of intestinal mucosal cell esterase and liver esterase, and ganciclovir generates ganciclovir triphosphate under the action of intraviral and intracellular enzyme phosphorylation Lowe, the latter competes with deoxyguanosine triphosphate (dGTP) as the substrate of viral DNA polymerase, thus inhibiting the synthesis of viral DNA, thereby producing anti-cytomegalovirus (CMV) activity, in vitro, ganciclovir against CMV The effect of ganciclovir is 26 times stronger than that ...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/01A61K9/20A61K47/36A61K47/26A61P31/18A61P31/12A61P27/02
CPCA61K31/522A61K31/01A61K9/2059A61K9/2018A61P31/18A61P31/12A61P27/02A61K2300/00
Inventor 王国军陈波奚忠田胜孙浩李志丹
Owner 湖北科益药业股份有限公司
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