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Fundus retina image segmentation method based on generative adversarial network

A technology of fundus images and retinal blood vessels, which is applied in the field of medical image processing, can solve problems such as blurred segmentation results and overfitting, and achieve the effect of easy capture, good effect, and large local information difference

Inactive Publication Date: 2019-12-13
HENAN UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

It is necessary to design the segmentation model based on the existing prior knowledge and complex probability and statistics methods, and it is necessary to assume that the training data and the test data obey the same distribution, which will cause the training results to be better than the test results, that is, the problem of overfitting , causing the segmentation results to be blurred, and the segmentation results need to be binarized after processing, which has certain limitations in the segmentation of retinal capillaries

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Embodiment Construction

[0013] In order to verify the retinal vessel segmentation performance of the present invention, we selected the DRIVE dataset for training and testing.

[0014] Step 1: Preprocessing the fundus image data, using Spyder software, adopting image rotation, translation transformation to carry out image enhancement, and the method of contrast enhancement to carry out image normalization processing.

[0015] Step 2: Train the C-GAN network in Spyder software, batch_size is 1, learning_rate is 2e-4, Adama optimizer is used, kinetic energy is 0.5 for optimization, training iterations are 20,000 times, and the training set and verification set are divided by 19:1 , intermittently train the above two processes, adjust the network parameters until the network converges, and the training ends.

[0016] Step 3: Test the C-GAN network using the test set of the DRIVE dataset. In order to evaluate the segmentation results, five commonly used evaluation criteria are used, accuracy (Acc), sens...

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Abstract

An existing fundus retina image segmentation technology has defects in retina vessel segmentation precision, and a good method for segmenting small capillaries does not exist. In order to realize accurate segmentation of a fundus retina image, the invention provides a fundus retina image segmentation method based on a generative adversarial network (C-GAN). The method comprises: a generation modelextracting abstract features through a coding-decoding network structure and carrying out detail recovery to obtain a blood vessel segmentation probability graph close to a sample true value; the discrimination network inputting the sample probability graph obtained by the generation model and a sample true value label into a deep convolutional network, giving a higher label to a real sample, andgiving a lower label to a generated sample. The network parameter weight is adjusted through mutual counterbalance of the generation model and the discrimination model, and the network converges thewhole network when the generation model and the discrimination model reach balance. According to the invention, tiny capillaries of the fundus image can be segmented, and the segmentation precision ofthe whole retinal vessel is improved.

Description

technical field [0001] The invention belongs to the technical field of medical image processing, and in particular relates to a method for segmenting retinal vessels in fundus images. Background technique [0002] The fundus is the only microcirculatory part of the human body where the blood circulation can be directly seen. Currently common fundus diseases that affect visual function such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion and other diseases are related to the diameter, curvature and branching form of retinal blood vessels. Or the morphological change of the angle is closely related. In ophthalmology, fundus examination is very important. Ophthalmologists observe the fundus retinal blood vessels as a window to understand the blood vessels of other organs. Many diseases can be reflected from the fundus. Therefore, the fundus is an important basis for diagnosing eye diseases and various diseases in the whole body. And early reti...

Claims

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Application Information

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IPC IPC(8): G06T7/143G06N3/04
CPCG06T7/143G06T2207/30041G06T2207/20084G06T2207/20081G06N3/045
Inventor 武婷婷杨铁军
Owner HENAN UNIVERSITY OF TECHNOLOGY
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