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Substrate solution for chemiluminescence immunoassay analyzer and preparation method thereof

A chemiluminescence immunoassay, analyzer technology, applied in chemiluminescence/bioluminescence, analysis by chemical reaction of materials, scientific instruments, etc., can solve the problems of poor signal-to-noise ratio, poor repeatability, and high price

Inactive Publication Date: 2019-12-13
山东康华生物医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign countries are represented by Abbott’s substrate solution. Domestic manufacturers such as Shenzhen Feipeng, Suzhou Changguang Huayi, Shenzhen Yahuilong, Weihai Weigao, Xiamen Wantai Kairui, and Nanjing Dignos have all developed their own substrates, but generally The signal-to-noise ratio and repeatability are not good. Abbott substrate solution is internationally recognized as a better product, but it is expensive

Method used

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  • Substrate solution for chemiluminescence immunoassay analyzer and preparation method thereof
  • Substrate solution for chemiluminescence immunoassay analyzer and preparation method thereof
  • Substrate solution for chemiluminescence immunoassay analyzer and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Embodiment 1: A substrate solution for a chemiluminescence immunoassay analyzer, including a pre-excitation solution and an excitation solution.

[0125] The pre-activation solution includes the following components:

[0126] Fluoboric acid: 0.05M;

[0127] h 2 0 2 : 0.2%;

[0128] EDTA: 5mM;

[0129] PC-300: 0.1%;

[0130] The excitation solution includes the following components:

[0131] NaOH: 0.1M;

[0132] NP-10: 2.5%;

[0133] DMF: 0.1%;

[0134] Krovin600: 1%.

Embodiment 2

[0135] Embodiment 2: A substrate solution for a chemiluminescence immunoassay analyzer, including a pre-excitation solution and an excitation solution.

[0136] The pre-activation solution includes the following components:

[0137] Fluoboric acid: 0.2M;

[0138] h 2 0 2 : 0.05%;

[0139] EDTA: 10mM;

[0140] PC-300: 0.05%;

[0141] The excitation solution includes the following components:

[0142] NaOH: 0.35M;

[0143] NP-10: 0.5%;

[0144] DMF: 0.25%;

[0145] Krovin600: 0.05%.

Embodiment 3

[0146] Embodiment 3: A substrate solution for a chemiluminescence immunoassay analyzer, including a pre-excitation solution and an excitation solution.

[0147] The pre-activation solution includes the following components:

[0148] Fluoboric acid: 0.125M;

[0149] h 2 0 2 : 0.125%;

[0150] EDTA: 7.5mM;

[0151] PC-300: 0.075%;

[0152] The excitation solution includes the following components:

[0153] NaOH: 0.225M;

[0154] NP-10: 1.5%;

[0155] DMF: 0.175%;

[0156] Krovin600: 0.075%.

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Abstract

The invention discloses a substrate solution for a chemiluminescence immunoassay analyzer and a preparation method thereof. The substrate solution is suitable for domestic and overseas full-automaticchemiluminiscence immunoassay analyzers such as Abbott and Kanghua, the cost is low, compared with a computer experiment of an Abbott substrate liquid, the technical scheme has the advantages of higher signal-to-noise ratio, higher luminous intensity and better measured value repeatability than the Abbott substrate liquid, the widely-sold and expensive Abbott substrate liquid on the market can becompletely and effectively replaced, and therefore, the problem that domestic hospitals and manufacturers excessively depend on import is effectively solved.

Description

technical field [0001] The invention relates to the technical field of chemiluminescence immunoassay. [0002] Specifically, it relates to a substrate solution for a chemiluminescence immunoassay instrument and a preparation method thereof. Background technique [0003] In the 1970s, the medical field of developed countries in Europe and the United States appeared to use chemiluminescence immunoassay method to detect human diseases. This technology combines chemiluminescence method and immune reaction, has the specificity of immune reaction, and is non-radioactive labeling, no radioactive pollution, is The latest detection technology in the in vitro diagnostic industry is widely favored by the laboratory departments of major tertiary hospitals at home and abroad. It is applied to the detection of heart markers, tumor markers, thyroid function, metabolism, sex hormones and other items. It has been popularized and developed abroad. It is still in its infancy in China and has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/531G01N21/76
CPCG01N33/531G01N21/76
Inventor 杨帆许建成任文波李志凯田永帅杨锋斌
Owner 山东康华生物医疗科技股份有限公司
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