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Gastrodin as alpha-glucosidase inhibitor and application thereof

A technology of glucosidase and gastrodin, applied in the direction of application, glycosylase, enzyme, etc., can solve undisclosed problems and achieve the effects of easy industrialization, good inhibition, and simple preparation process

Pending Publication Date: 2019-12-13
湖北菜鲜鲜食材供应链有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the prior art does not disclose a continuous low-temperature and

Method used

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  • Gastrodin as alpha-glucosidase inhibitor and application thereof
  • Gastrodin as alpha-glucosidase inhibitor and application thereof
  • Gastrodin as alpha-glucosidase inhibitor and application thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0036] Example 1

[0037] A use of gastrodin extract as an α-glucosidase enzyme inhibitor. The gastrodin extract is used as one of the active ingredients or the only active ingredient to prepare the α-glucosidase inhibitor.

[0038] A use of gastrodin extract as an α-glucosidase inhibitor, the gastrodin extract is used as one of the active ingredients or the only active ingredient for reducing postprandial blood glucose levels.

[0039] The preparation process of the gastrodin extract includes the steps of solid-fermenting the gastrodia medicinal materials with Trichoderma viride, including the following steps:

[0040] (1) Dry heat sterilization of dried gastrodia elata;

[0041] (2) Crush the sterilized gastrodia elata medicinal materials and add water to mix them into a wet material;

[0042] (3) Add comprehensive potato culture medium and Trichoderma viride suspension, and mix;

[0043] (4) Carry out solid fermentation for 4 days to obtain fermentation material;

[0044] (5) The fermen...

Example Embodiment

[0056] Example 2

[0057] A use of gastrodin extract as an α-glucosidase enzyme inhibitor, and the gastrodin extract is used as one of or the only active component to prepare the α-glucosidase inhibitor.

[0058] A use of gastrodin extract as an α-glucosidase inhibitor, the gastrodin extract is used as one of the active ingredients or the only active ingredient for lowering postprandial blood glucose levels.

[0059] The preparation process of the gastrodin extract includes the steps of solid fermentation of gastrodia elata with Trichoderma viride, including the following steps:

[0060] (1) Dry heat sterilization of dried gastrodia elata;

[0061] (2) Crush the sterilized gastrodia elata powder and add water and mix it into a wet material;

[0062] (3) Add comprehensive potato culture medium and Trichoderma viride suspension, and mix;

[0063] (4) Carry out solid fermentation for 6 days to obtain fermentation material;

[0064] (5) The fermented material is dried and crushed and then extr...

Example Embodiment

[0076] Example 3

[0077] A use of gastrodin extract as an α-glucosidase enzyme inhibitor, and the gastrodin extract is used as one of or the only active component to prepare the α-glucosidase inhibitor.

[0078] A use of gastrodin extract as an α-glucosidase inhibitor, the gastrodin extract is used as one of the active ingredients or the only active ingredient for lowering postprandial blood glucose levels.

[0079] The preparation process of the gastrodin extract includes the steps of solid fermentation of gastrodia elata with Trichoderma viride, including the following steps:

[0080] (1) Dry heat sterilization of dried gastrodia elata;

[0081] (2) Crush the sterilized gastrodia elata powder and add water and mix it into a wet material;

[0082] (3) Add comprehensive potato culture medium and Trichoderma viride suspension, and mix;

[0083] (4) Carry out solid fermentation for 8 days to obtain fermentation material;

[0084] (5) The fermented material is dried and crushed and then extr...

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Abstract

The invention discloses a gastrodin extract as an alpha-glucosidase inhibitor and application of the gastrodin extract in food for special dietary uses. According to the invention, the gastrodin extract is used as one or only one active ingredient for preparing the alpha-glucosidase inhibitor; according to the gastrodin, solid fermentation treatment is conducted on a smashed radix puerariae medicinal material through trichoderma viride, and then extraction is conducted. The gastrodin extraction yield can be greatly increased, and a gastrodin extract with advantages of high content, good quality and low cost is provided for the preparation of a gastrodin monomer. The experimental result of the alpha-glucosidase activity of the gastrodin provides reliable experimental and theoretical basis for the application of the gastrodin in the field of reducing the postprandial blood sugar level, and also provides a new way for high-valued utilization of gastrodin resources in food for special dietary uses.

Description

technical field [0001] The invention relates to the technical field of analysis and extraction of functional food factors, in particular to the use of gastrodin extract as an α-glucosidase inhibitor in hypoglycemic food or health food and its preparation method. Background technique [0002] Gastrodia elata is a perennial herbaceous parasitic plant of the Orchidaceae Gastrodia genus. It has thick rhizomes. Its rhizomes are used as medicine to treat dizziness, numbness of limbs and convulsions in children. Treat headache, insomnia. The main medicinal component of Gastrodia elata tubers is gastrodin, which is extracted from the tubers of Gastrodia elata. Gastrodin can significantly reduce the activity of extracellular LDH in HUVECs stimulated by high glucose, and reduce the damage caused by high glucose to vascular endothelial cells; gastrodin can significantly reduce blood sugar in diabetic mice, and reduce serum triglycerides, total cholesterol and Malondialdehyde concentr...

Claims

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Application Information

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IPC IPC(8): C12N9/26C12P19/44A23L33/105C12R1/885
CPCC12N9/2408C12Y302/0102C12P19/44A23L33/105A23V2002/00A23V2200/328A23V2250/21
Inventor 刘志伟李明何丽丽
Owner 湖北菜鲜鲜食材供应链有限公司
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