an injection filler

Abstract

The present invention combines PCL (polycaprolactone), PGA (polyglycolide), PVA (polyvinyl alcohol), PLA (polylactic acid), PDO (polydioxanone), P-TMC (polytrimethylene Homopolymers or copolymers of absorbable synthetic polymer materials such as carbonate) are prepared into absorbable synthetic polymer microspheres less than 200 microns, and then dispersed in cross-linked sodium hyaluronate gel to obtain degradation time Long-lasting, controlled injectable fillers. In addition, when surfactants such as CMC (carboxymethyl cellulose) and MC (methyl cellulose) are added to the mixed system of sodium hyaluronate gel and absorbable polymer microspheres at a very low ratio, it can It has a very good protective effect on the shape maintenance of the microspheres in the wet heat sterilization. In the present invention, absorbable synthetic polymer microspheres are used to prolong the degradation cycle of injection fillings. In addition, surfactants are added to the injection fillings to protect the surface of absorbable synthetic polymer microspheres and prevent them from softening under high temperature. out of shape.

Description

technical field [0001] The invention relates to the technical field of cosmetic fillers, in particular to an injection filler. Background technique [0002] Since the 1990s, the country has established "medical cosmetology" as a "first-level diagnosis and treatment subject" in medical institutions, and the medical cosmetology market has gradually grown. Among them, micro-plastic surgery is the main development trend at present, and injection filling is one of the main plastic methods in micro-plastic surgery. It has the advantages of no need for surgery, small postoperative wounds, and short trauma time. [0003] There are two deficiencies in the existing hyaluronic acid-based injection fillers: [0004] 1. It is often a sterile filling product, which requires very strict intermediate process control without terminal sterilization, high production management costs, and low guarantee for the sterility of the final product; [0005] 2. The degradation time of hyaluronic acid...

AI Technical Summary

Problems solved by technology

[0004] 1. It is often a sterile filling product, which requires very strict intermediate process control without terminal sterilization, high production management costs, and low guarantee for the sterility of the final product;

[0005] 2. The degradation time of hyaluronic acid is too fast, and it is difficult to maintain the clinical application effect after implantation. Even the cross-linked sodium hyaluronate gel can only maintain the degradation time of half a year

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