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Microsphere screen, production-type high-efficiency microsphere collection device and application thereof

A collection device and microsphere technology, which is applied in the direction of filtration and separation, fixed filter elements, chemical instruments and methods, etc., can solve the problems of increased filtration resistance, stuck sieve holes, and decreased sieving efficiency, so as to reduce energy consumption. Consumption, meeting production requirements, high removal efficiency

Pending Publication Date: 2019-12-10
ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the prolongation of time, the accumulation of large particles on the screen surface is also increasing, and the filtration resistance increases, resulting in a decrease in screening efficiency.
After the microspheres are solidified in the solution, the water and residual solvents have not been completely removed. The glass transition temperature (Tg) of the microspheres is usually not too high, which means that the texture of the microspheres is relatively soft. Although increasing the pump pressure at this time can temporarily improve Filtration rate, under the extrusion of external force, the microspheres are prone to slight deformation, stuck in the sieve, and finally the excessive pressure will cause the damage of the sieve and the loss of the whole batch of materials
At this time, it is necessary to stop periodically to process the particles on the surface of the screen, which brings a lot of trouble to the aseptic process

Method used

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  • Microsphere screen, production-type high-efficiency microsphere collection device and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The present invention provides a microsphere screen, comprising a vertical screen 4 and a split flow unit 5 fixed in the vertical screen 4, see figure 1 .

[0044] In the embodiment of the present application, each branching unit 5 is composed of a left-handed unit piece 5a and a right-handed unit piece 5b; preferably, the number of five branching units is 15-20.

Embodiment 2

[0046] figure 1 It is a schematic diagram of the device of the present invention. A production-type high-efficiency microsphere collection device provided by the present invention includes a vertical screen 4, a flow diversion unit 5, a collection unit 6, a sealed casing 9, and a liquid discharge unit. The vertical screen The net 4 is penetrated and fixed in the sealed casing 9 to form a screening chamber, the upper end of the screening chamber is the feed liquid inlet 1 for feeding, the lower end of the screening chamber is connected to the collection unit, and the side wall of the screening chamber is connected to the drain unit.

[0047] In the embodiment of the present application, each branching unit 5 is composed of a left-handed unit piece 5a and a right-handed unit piece 5b; preferably, the number of five branching units is 15-20.

[0048] In the embodiment of the present application, the upper end of the screening chamber is sequentially connected to the connection f...

Embodiment 3

[0053] The risperidone microspheres were collected by the above-mentioned device, and the target particle size was 25-150 μm. The volume of feed liquid is 500L, and the solid content accounts for about 0.25%. The microsphere collection device is placed in the B-level area. The feed liquid inlet of the microsphere collection device is connected to the microsphere preparation system through the connecting flange, and the concentrated liquid outlet is connected to the 2L stainless steel barrel through the AB valve. A 150μm screen is installed at the downstream end of the microsphere preparation system to pre-filter large-particle microspheres (accounting for <1%). The pre-filtered feed liquid is pressed into the collection device, and the flow rate is controlled to stabilize at 8-12L / min. When the liquid flows through the vertical sieve (the sieve diameter is 25 μm), tangential flow filtration occurs under the action of the splitter unit, small particles and solutions pass throug...

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Abstract

The invention discloses a microsphere screen, a production-type high-efficiency microsphere collection device and an application thereof. The microsphere screen comprises a vertical screen and flow dividing units fixed in the vertical screen. The collection device comprises the vertical screen, the flow dividing units, a material collecting unit, a sealing shell and a liquid discharge unit. The vertical screen is fixed in the sealing shell in a penetrating manner to form a screening cavity, the upper end of the screening cavity is used for feeding materials, the lower end of the screening cavity is connected to the material collecting unit, and the side wall of the screening cavity is connected to the liquid discharge unit. After a material liquid is distributed by the flow dividing units,water is removed through the vertical screen. The outer side of the vertical screen is provided with the sealing shell connected to a pump. The concentrated material liquid after the water removal iscollected by a material collecting port. The microsphere collection device of the invention is particularly suitable for collecting microspheres with average particle sizes D50 of 40-90mum.

Description

technical field [0001] The invention belongs to the technical field of microsphere screening and selection, and in particular relates to a microsphere screen, a production-type high-efficiency microsphere collection device and applications thereof, which are applied to the concentration and collection of microsphere preparations in the field of pharmaceutical preparations. [0002] Background of the invention [0003] Microspheres refer to the microparticle dispersion system formed by dispersing or adsorbing drugs in macromolecules and polymer matrices. Microspheres can be administered through intramuscular, subcutaneous, vitreous and intraarticular injections to increase drug residence time, increase local drug concentration, and reduce systemic reactions. [0004] Microsphere preparation methods mainly include the following: solvent evaporation method, solvent extraction method, phase separation method, hot melt extrusion method, spray drying method, rotary disk method, etc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D29/35B01D29/90B01D29/92
CPCB01D29/35B01D29/904B01D29/92
Inventor 于崆峒蒋朝军方晓云刘喜明
Owner ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
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