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Methods for preparing biodegradable body temperature induction material and degradable body temperature induction memory bioscaffold for 4D printing

A technology of sensing materials and bio-stents, which is applied in additive processing, medical science, surgery, etc., to achieve fast molding speed, narrow thermal transition peak width, and reduce the pain of patients

Pending Publication Date: 2019-12-03
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In view of this, there is still a lack of a 4D printing degradable body temperature sensing material with

Method used

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  • Methods for preparing biodegradable body temperature induction material and degradable body temperature induction memory bioscaffold for 4D printing
  • Methods for preparing biodegradable body temperature induction material and degradable body temperature induction memory bioscaffold for 4D printing
  • Methods for preparing biodegradable body temperature induction material and degradable body temperature induction memory bioscaffold for 4D printing

Examples

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preparation example Construction

[0050] A method for preparing a biodegradable body temperature sensing material, by using a biodegradable polymer terminal with a hydroxyl group (ie, a hydroxyl-terminated biodegradable polymer) as the basic main raw material to prepare a material that can be degraded at a physiological temperature and has a sulfhydryl group terminal. or norbornene-based multicomponent biodegradable polymers, that is, multicomponent biodegradable polymers terminated by mercapto or norbornene groups. The material is applied to the field of 4D printing. It is a multi-component biodegradable polymer terminated by a mercapto or norbornene group and a corresponding two-arm or multi-arm norbornene or mercapto-terminated degradable macromolecule. Next, photocatalytic norbornene-sulfhydryl click chemistry reaction occurred. The biostents prepared by this reaction, such as vascular stents, have the advantages of fast recovery of shape and structure, more accurate recovery temperature and controllable d...

Embodiment 1

[0071] Add 0.076mmol of stannous octoate, 69.6mmol of trimethylene carbonate, 309.6mmol of D, L-lactide and 50mmol of pentaerythritol into an anhydrous and oxygen-free reaction flask, vacuumize and blow nitrogen, repeat three times. After the reaction system was sealed, it was reacted in an oil bath at 130°C for 24 hours. After the reaction was completed, the reaction system was cooled to room temperature, and an appropriate amount of chloroform was added to dissolve the product. Slowly add the reaction mixture dropwise into cold methanol for precipitation, where the volume of methanol is 5-10 times the volume of the chloroform solution of the reactant, and then dissolve and precipitate again after filtration to obtain the hydroxyl-terminated four-arm poly D,L-lactate Ester-co-trimethylene carbonate copolymer (M n =1568; M w =1770;T g =34~36℃), such as Figure 9 Tan δ–temperature curves of the shown hydroxyl-terminated four-armed poly-D,L-lactide-co-trimethylene carbonate ...

Embodiment 2

[0075] Compared with Embodiment 1, this embodiment is the same except for the following differences. The only difference is that tetrakis(3-mercaptopropionate) pentaerythritol is replaced by trimethylolpropane tris(3-mercaptopropionate).

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Abstract

The invention discloses methods for preparing a biodegradable body temperature induction material and a degradable body temperature induction memory bioscaffold for 4D printing. The method for preparing the material comprises the steps of preparing multicomponent biodegradable macromolecules, of which terminals are mercapto or norbornenyl, by taking biodegradable macromolecules, of which terminalsare hydroxyl, as a main body. The method for preparing the bioscaffold comprises the steps: subjecting polyfunctional mercapto micromolecules or norbornene micromolecules and the biodegradable body temperature induction material to a norbornene-mercapto photopolymerization reaction through 4D printing, so as to obtain a bioscaffold; and heating the temperature of the bioscaffold to a melting point temperature or be above a vitrification temperature, carrying out compressing along a diametrical direction to reduce a size, and then, fixing a temporary shape nearby a zero temperature, thereby obtaining the degradable body temperature induction memory bioscaffold. The methods have the characteristics of high printing speed, no oxygen inhibition and no shrinkability and have the advantages that the thermal transformation peak width is narrow, the return speed is high, the return temperature is accurate, a controllable degradation rate is also taken into account, and the like.

Description

technical field [0001] The invention belongs to the technical field of 4D printing materials, and in particular relates to a preparation method of a biodegradable body temperature sensing material for 4D printing and a degradable body temperature sensing memory bio-stent. Background technique [0002] Cardiovascular disease has become the number one health killer worldwide. At present, the most effective treatment for this disease is balloon transluminal coronary angioplasty (PTCA), which uses stent materials to provide radial support for blood vessels to prevent restenosis, thereby achieving the purpose of treatment. The implantation of the most commonly used balloon-expandable stent is to press the stent on the guide wire with a balloon at the end, send the stent to the coronary lesion through the balloon catheter, and then use the pressure of the balloon to expand and release the stent. stand. According to statistics, in 2006, there were about 2.4 million cases of cardi...

Claims

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Application Information

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IPC IPC(8): C08G64/42C08G64/30C08G64/18C08G63/08C08G63/78C08G63/91A61L31/14A61L31/06B33Y70/00B33Y10/00B33Y80/00
CPCA61L31/06A61L31/145A61L31/148B33Y10/00B33Y70/00B33Y80/00C08G63/08C08G63/78C08G63/912C08G64/18C08G64/305C08G64/42C08G2230/00
Inventor 李兴建
Owner LINYI UNIVERSITY
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