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Composition with oral cavity health care function and preparing method and application thereof

An oral health care and composition technology, which is applied in the directions of oral care, drug combination, pharmaceutical formulation, etc., can solve the problems of human side effects, the ecological balance of oral bacteria, gingival bleeding and gingivitis, and hinder the application of oral products. The effect of preventing bleeding gums and gingivitis, inhibiting harmful bacteria in the oral cavity, and maintaining the balance of oral flora

Inactive Publication Date: 2019-11-22
沈阳天然纳美科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although drugs can solve oral problems, they will also cause certain side effects to the human body; therefore, it is urgent to develop an oral product that can solve oral health problems and avoid side effects caused by drugs
[0005] At present, some compounds that have beneficial effects on the oral cavity and gums face the following problems in the application and development of oral products such as toothpaste: low solubility, poor transmucosal absorption, and low bioavailability, especially for active ingredients that are insoluble in water and esters , which seriously hinders its application in oral products
[0006] In summary, in view of the current oral care products, the ecological balance of oral bacteria, gingival bleeding and gingivitis have no obvious improvement effect, the active ingredients have poor solubility, poor transmucosal absorption, and low bioavailability. There is an urgent need to develop oral care products that can better improve oral health, have high absorption and bioavailability

Method used

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  • Composition with oral cavity health care function and preparing method and application thereof
  • Composition with oral cavity health care function and preparing method and application thereof
  • Composition with oral cavity health care function and preparing method and application thereof

Examples

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preparation example Construction

[0105] The preparation method of glycyrrhetinic acid nanoparticles is as follows: Glycyrrhetinic acid and TPGS (the molecular weight of PEG is 2000) with a mass ratio of 5:1 are co-dissolved in ethanol, and the mass volume ratio of glycyrrhetinic acid to ethanol (g / L) 50:1, injected into 10 times the volume of water under ultrasonic conditions of 25°C, 24KHZ and 250W, and removed ethanol by rotary evaporation at 45°C to obtain white opalescent and uniform glycyrrhetinic acid nanoparticles with an average particle size of 145.0nm, PDI value is 0.185, surface potential is -28.6mV, concentration is 1mg / mL.

[0106]The preparation method of totomol nanoparticles is as follows: the mass ratio of totomol and TPGS (the molecular weight of PEG is 2000) is co-dissolved in ethanol, the mass volume ratio of totomol to ethanol (g / L) 20:1, injected into 10 times the volume of water under ultrasonic conditions of 25°C, 24KHZ, and 250W, and removed ethanol by rotary evaporation at 45°C, that...

Embodiment 1

[0111] The present embodiment provides a kind of composition, by weight, its formula is as follows:

[0112] Glycyrrhetinic acid 0.001 part;

[0113] 0.5 parts of dandelion extract;

[0114] Totol 0.0012 parts.

Embodiment 2

[0116] The present embodiment provides a kind of composition, by weight, its formula is as follows:

[0117] Glycyrrhetinic acid 0.08 parts;

[0118] 5 parts of dandelion extract;

[0119] Totol 0.08 parts.

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PUM

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Abstract

The invention relates to the technical field of daily chemical products, in particular to a composition with an oral cavity health care function and a preparing method and application thereof. The composition comprises glycyrrhetinic acid, a herba taraxaci extract, totarol and a krameria triandra extract. According to the composition, different medicinal mechanisms of various components are utilized, the glycyrrhetinic acid, the herba taraxaci extract and the totarol are compounded and further supplemented with the krameria triandra extract, and thus full is given to the synergistic effects ofall the components. In the meanwhile, effective components which are hard to dissolve, disperse and absorb are subjected to nanocrystallization, so that the absorptivity and bioavailability of the components by the mouth mucosa are significantly increased, and it is guaranteed that the effective components play a synergistic effect to the greatest extent. The obtained composition has the functions of inhibiting helicobacter pylori and other bacteria harmless to the oral cavity, maintaining the balance of the flora of the oral cavity, and preventing and relieving gingival bleeding, gingivitisand inflammations of the oral cavity; meanwhile, the composition has the advantages of being natural in raw material, wide in source, safe to the human body, low in cost, convenient to produce and thelike.

Description

technical field [0001] The invention relates to the technical field of daily chemical products, in particular to a composition with oral health care function and its preparation method and application. Background technique [0002] Oral health largely reflects people's physical health and affects people's quality of life. For example, bad breath brings social embarrassment to people and makes them unable to communicate closely with others; Taste all the flavors of the world. [0003] Oral health is affected to some extent by the pathogenic bacteria in the oral cavity. At present, studies have confirmed that there are more than 700 known species of bacteria in the oral cavity. Only when a good ecological balance is maintained between the microorganisms in the oral cavity and between the microorganisms and the oral tissues of the host can the oral cavity maintain a healthy state. Helicobacter pylori is a spiral-shaped, micro-anaerobic bacteria that requires very harsh growth...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/63A61K8/34A61Q11/00A61P1/02A61P7/04A61P31/02
CPCA61K8/9789A61K8/63A61K8/347A61Q11/00A61P1/02A61P7/04A61P31/02
Inventor 胡国华王莉莉李翠红
Owner 沈阳天然纳美科技有限公司
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