Composition with oral cavity health care function and preparing method and application thereof
An oral health care and composition technology, which is applied in the directions of oral care, drug combination, pharmaceutical formulation, etc., can solve the problems of human side effects, the ecological balance of oral bacteria, gingival bleeding and gingivitis, and hinder the application of oral products. The effect of preventing bleeding gums and gingivitis, inhibiting harmful bacteria in the oral cavity, and maintaining the balance of oral flora
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[0105] The preparation method of glycyrrhetinic acid nanoparticles is as follows: Glycyrrhetinic acid and TPGS (the molecular weight of PEG is 2000) with a mass ratio of 5:1 are co-dissolved in ethanol, and the mass volume ratio of glycyrrhetinic acid to ethanol (g / L) 50:1, injected into 10 times the volume of water under ultrasonic conditions of 25°C, 24KHZ and 250W, and removed ethanol by rotary evaporation at 45°C to obtain white opalescent and uniform glycyrrhetinic acid nanoparticles with an average particle size of 145.0nm, PDI value is 0.185, surface potential is -28.6mV, concentration is 1mg / mL.
[0106]The preparation method of totomol nanoparticles is as follows: the mass ratio of totomol and TPGS (the molecular weight of PEG is 2000) is co-dissolved in ethanol, the mass volume ratio of totomol to ethanol (g / L) 20:1, injected into 10 times the volume of water under ultrasonic conditions of 25°C, 24KHZ, and 250W, and removed ethanol by rotary evaporation at 45°C, that...
Embodiment 1
[0111] The present embodiment provides a kind of composition, by weight, its formula is as follows:
[0112] Glycyrrhetinic acid 0.001 part;
[0113] 0.5 parts of dandelion extract;
[0114] Totol 0.0012 parts.
Embodiment 2
[0116] The present embodiment provides a kind of composition, by weight, its formula is as follows:
[0117] Glycyrrhetinic acid 0.08 parts;
[0118] 5 parts of dandelion extract;
[0119] Totol 0.08 parts.
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