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Bile acid synthesis promoter, composition for promoting bile acid synthesis and food composition for promoting bile acid synthesis

A bile acid and composition technology is applied in the directions of food ingredients containing organic compounds, food ingredients containing natural extracts, medical preparations containing active ingredients, etc., to achieve the effect of promoting cholesterol metabolism and promoting bile acid synthesis

Pending Publication Date: 2019-11-12
KRACIE HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is known that if the amount of cholesterol in the blood becomes excessive, it causes lifestyle diseases such as arteriosclerosis

Method used

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  • Bile acid synthesis promoter, composition for promoting bile acid synthesis and food composition for promoting bile acid synthesis
  • Bile acid synthesis promoter, composition for promoting bile acid synthesis and food composition for promoting bile acid synthesis
  • Bile acid synthesis promoter, composition for promoting bile acid synthesis and food composition for promoting bile acid synthesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] (Manufacture 1 of Example 1 Burdock Fruit Extract)

[0069] As an example of the composition for bile acid synthesis promotion of this invention, the extract (extract) was extracted from the burdock fruit. The burdock seeds (enzyme activity 8.23 ​​U / g) were cut, and those that all passed through the 9.5 mm sieve were further passed through the 0.85 mm sieve to confirm that 75% remained. 80 kg of the minced burdock fruit was added to 560 L of water kept at 29 to 33° C., and stirred for 30 minutes. Then, 265 L of ethanol was added, the temperature was raised to 85° C., and the mixture was heated to reflux for 60 minutes. This solution was centrifuged to obtain a burdock fruit extract. The extracts obtained by repeating this operation twice were combined, concentrated under reduced pressure, added dextrin in an amount of 25% to the solid content of the extract, and spray-dried. The contents of arctigenin and arctiin were 6.2% and 7.1%, respectively, and arctigenin / arcti...

Embodiment 2

[0070] (Manufacture 2 of Example 2 Burdock Fruit Extract)

[0071] As an example of the composition for bile acid synthesis promotion of this invention, the extract (extract) was extracted from the burdock fruit. The burdock seeds (enzyme activity 8.23 ​​U / g) were cut, and those that all passed through the 9.5 mm sieve were further passed through the 0.85 mm sieve to confirm that 75% remained. 80 kg of the minced burdock fruit was added to 560 L of water kept at 30 to 33° C., stirred for 30 minutes, and then 265 L of ethanol was added to raise the temperature to 85° C. and heated to reflux for 30 minutes. This solution was centrifuged to obtain a burdock fruit extract. The extracts obtained by repeating this operation twice were combined, concentrated under reduced pressure, added dextrin in an amount of 25% to the solid content of the extract, and spray-dried. The contents of arctigenin and arctiin were 6.0% and 6.8%, respectively, and arctigenin / arctiin (weight ratio) = 0....

Embodiment 3

[0072] (Manufacture 3 of Example 3 Burdock Fruit Extract)

[0073] As an example of the composition for bile acid synthesis promotion of this invention, the extract (extract) was extracted from the burdock fruit. The burdock seeds (enzyme activity 7.82 U / g) were cut, and those that all passed through the 9.5 mm sieve were further passed through the 0.85 mm sieve, and 75% remained. 80 kg of the minced burdock was added to 560 L of water kept at 30-32° C., stirred for 40 minutes, and 60 minutes later, 258 L of ethanol was added to raise the temperature to 85° C. and heated to reflux for 30 minutes. This solution was centrifuged to obtain a burdock fruit extract. The extracts obtained by repeating this operation twice were combined, concentrated under reduced pressure, added dextrin in an amount of 25% to the solid content of the extract, and spray-dried. The contents of arctigenin and arctiin were 6.2% and 6.7%, respectively, and arctigenin / arctiin (weight ratio) = 0.93 was ob...

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Abstract

To provide a novel medicine that is capable of promoting cholesterol metabolism to thereby treat, ameliorate or prevent various symptoms associated with increase in blood cholesterol level. The present inventors newly found that arctigenin has an effect of promoting the conversion of cholesterol into bile acid. The present invention provides a bile acid synthesis promoter, a composition for promoting bile acid synthesis and a food composition for promoting bile acid synthesis each comprising arctigenin and / or arctiin as active ingredient(s).

Description

technical field [0001] The present invention relates to a bile acid synthesis promoter capable of promoting synthesis of bile acid from cholesterol in the liver, a composition for promoting bile acid synthesis, and a food composition for promoting bile acid synthesis. Background technique [0002] Cholesterol is an important component involved in various physiological phenomena of living organisms. However, it is known that if the amount of cholesterol in the blood becomes excessive, lifestyle diseases such as arteriosclerosis are caused. Cholesterol forms complexes with proteins in the blood and exists in the form of lipoproteins. Among such lipoproteins, low-density lipoprotein cholesterol (LDL cholesterol) is said to promote arteriosclerosis. Therefore, it is considered that arteriosclerosis can be improved by reducing lipids in blood, especially LDL cholesterol. [0003] Cholesterol is converted to bile acids in the liver and excreted from the intestines. Bile acid s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/341A23L33/105A61K31/7048A61K36/28A61K36/634A61P3/06A61P43/00
CPCA23L33/105A61K31/341A61K31/7048A61K36/28A61K36/634A61P3/06A61P9/10A61P1/16A61K2236/331A61K2236/333A61K9/1623A61K9/2054A61K31/365A61K36/63A61P43/00A23L33/10A23V2002/00A23V2250/21A23V2250/30A23V2200/3262
Inventor 渡部晋平稻益悟志渡边光博高科庸子
Owner KRACIE HLDG
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