Tumor necrosis targeting compositions and methods

Abstract

Compositions and methods employ an anti-nucleolin antibody or fragment thereof to specifically target necrotic tumor cells. Thus, and in preferred aspects, compositions and methods may be used to target the tumor microenvironment and cancer cells within such milieu. Also included are methods of targeting necrotic cells with binding agent that specifically binds nucleolin.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to U.S. Provisional Patent Application Serial No. US 62 / 473,552, filed March 20, 2017, the contents of which are incorporated herein by reference. technical field [0003] The field of the invention is compositions and methods for targeting necrotic cells, and especially necrotic cells in solid tumors. Background technique [0004] The Background Description includes information useful in understanding the present invention. It is not an admission that any information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. [0005] All publications and patent applications are herein incorporated by reference to the same extent as if each individual such publication or patent application was specifically and individually indicated to be incorporated by reference. Where a defi...

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Problems solved by technology

However, to date there are no known established therapeutic interventions utilizing such target molecules

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