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An external compound preparation for improving psoriasis skin symptoms and its application

A compound preparation, psoriasis technology, applied in the field of external medicine, can solve the problems of fewer psoriasis and fewer active sites

Active Publication Date: 2021-04-20
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on the external use of traditional Chinese medicine in the treatment of psoriasis, and there are even fewer studies on the active parts

Method used

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  • An external compound preparation for improving psoriasis skin symptoms and its application
  • An external compound preparation for improving psoriasis skin symptoms and its application
  • An external compound preparation for improving psoriasis skin symptoms and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Anti-psoriasis ointment and its preparation

[0036] Prescriptions: Nepeta 100g, Fangfeng 100g, Notopterygium 100g, Clematis 150g, Angelica 120g, Chuanxiong 100g, Baixianpi 150g.

[0037] preparation:

[0038] (1) Weigh notopterygium, clematis, and white fresh skin by weight, crush the medicinal materials through a 40-mesh sieve, and mix the medicinal powder; add 4000g of 80% ethanol to the medicinal powder, soak for 1 hour, and reflux extraction at 80°C for 3 times, Extract for 2 hours each time, combine the filtrates, recover ethanol to collect the dry paste, and crush the dry paste through a 120-mesh sieve.

[0039] (2) Weigh Schizonepetae, Fangfeng, Angelica, and Chuanxiong by weight, crush the medicinal materials through a 30-mesh sieve, and mix the medicinal powder; add 4200g of water to the medicinal powder and soak for 1 hour, steam distillation and extraction at 75°C for 9 hours, and the distillate is dehydrated and collected Volatile oil.

[0040]...

Embodiment 2

[0042] Embodiment 2 anti-psoriasis ointment and preparation

[0043] Prescription: Nepeta 100g, Fangfeng 100g, Notopterygium 100g, Clematis 150g, Angelica 120g, Chuanxiong 100g, White Fresh Peel 150g, Yellow Zero Grass 120g, Hejincao 170g.

[0044] preparation:

[0045] (1) Weigh notopterygium, clematis, white fresh skin, and yellow zero grass by weight, crush the medicinal materials through a 40-mesh sieve, and mix the medicinal powder; add 5200g of 80% ethanol to the medicinal powder, soak for 1 hour, and reflux at 80°C Extract 3 times, extract 2 hours each time, combine the filtrates, recover ethanol to collect the dry paste, and crush the dry paste through a 120-mesh sieve.

[0046] (2) Weigh Schizonepetae, Fangfeng, Angelica, Chuanxiong, and Hejincao by weight, crush the medicinal materials through a 30-mesh sieve, and mix the medicinal powder; add 5900g of water to the medicinal powder and soak for 1 hour, extract by steam distillation at 75°C for 9 hours, distill The ...

Embodiment 3

[0049] Embodiment 3 anti-psoriasis gel and preparation

[0050] Prescription: Nepeta 100g, Fangfeng 100g, Notopterygium 100g, Clematis 150g, Angelica 120g, Ligusticum chuanxiong 100g, Fresh Cortex 150g, Grass 150g, and Grass 130g.

[0051] preparation:

[0052] (1) Weigh notopterygium, clematis, white fresh skin, and yellow zero grass by weight, crush the medicinal materials through a 40-mesh sieve, and mix the medicinal powder; add 5500g of 80% ethanol to the medicinal powder, soak for 1 hour, and reflux at 80°C Extract 3 times, extract 2 hours each time, combine the filtrates, recover ethanol to collect the dry paste, and crush the dry paste through a 120-mesh sieve.

[0053] (2) Weigh Schizonepetae, Fangfeng, Angelica, Chuanxiong and Hejincao by weight, crush the medicinal materials through a 30-mesh sieve, and mix the medicinal powder; add 5500g of water to the medicinal powder and soak for 1 hour, extract by steam distillation at 75°C for 9 hours, distill The liquid is ...

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Abstract

The invention belongs to the field of medicine for external use, and specifically invents an external compound preparation for improving psoriasis skin symptoms and its application. The external compound preparation for improving the skin symptoms of psoriasis is made from Nepeta, Fangfeng, Notopterygium, Clematis, Angelica, Chuanxiong, and Baixianpi, and other drugs such as Huanglingcao and Hejincao can be added. Among them, notopterygium, Clematis clematis, Bacteria chinensis, and Huang Lingcao were extracted by ethanol reflux method; Nepeta, Fangfeng, Angelica, Chuanxiong, and jincao were extracted by steam distillation. The dosage form of the external compound preparation for improving psoriatic skin symptoms can be external ointment, external gel or external lotion, which is applied to the affected part of the skin. The external compound preparation for improving psoriasis skin symptoms has the effect of improving psoriasis and is convenient to use.

Description

technical field [0001] The invention belongs to the field of medicine for external use, and specifically invents an external compound preparation for improving psoriasis skin symptoms and its application. Background technique [0002] Psoriasis, also known as psoriasis, is a chronic skin disease that is prone to recurrence. Due to the excessive proliferation of skin cells, the nuclear division of epidermal cells is accelerated, and erythema and scales appear on the skin. Western medicine has not yet studied the etiology and pathogenesis of psoriasis clearly. It is believed that it may be related to genetics, metabolic disorders, infection, immune dysfunction, etc. Seasonal changes, humidity, and mental trauma may also induce psoriasis. Retinoic acid and some monoclonal antibodies are commonly used drugs for the treatment of psoriasis in Western medicine. Among them, retinoic acid works by inhibiting the proliferation of keratinocytes, which can easily cause dry skin, itching...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61P17/06
CPCA61K9/0014A61K36/185A61K36/232A61K36/236A61K36/237A61K36/238A61K36/36A61K36/538A61K36/716A61K36/75A61K2236/331A61K2236/333A61K2236/39A61P17/06A61K2300/00
Inventor 袁锐孙起超郑毅
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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