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An analysis method for predicting weight gain in schizophrenia treated with second-generation antipsychotic drugs based on multigene combination interactions

A technology for antipsychotic drugs and schizophrenia, applied in the medical field, can solve the problems of marker screening deviation, can not truly and effectively reflect genetic polymorphism information, etc., and achieve the effect of reasonable screening, application scope and prediction accuracy improvement.

Active Publication Date: 2020-05-19
SECOND AFFILIATED HOSPITAL OF XINJIANG MEDICAL UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide an analysis method for predicting weight gain caused by second-generation antipsychotic drugs in treatment of schizophrenia based on the interaction of multiple genes. The generalized multi-factor dimensionality reduction method is used to deal with continuous outcome variables, and covariates are included. Its application range and prediction accuracy have been greatly improved, so as to solve the problem that the model cannot truly and effectively reflect the genetic polymorphism information, and the selection of markers is biased

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  • An analysis method for predicting weight gain in schizophrenia treated with second-generation antipsychotic drugs based on multigene combination interactions
  • An analysis method for predicting weight gain in schizophrenia treated with second-generation antipsychotic drugs based on multigene combination interactions

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Embodiment Construction

[0020] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0021] see figure 1 , the present invention provides an analysis method for predicting weight gain caused by second-generation antipsychotic drugs in the treatment of schizophrenia based on the interaction of multiple genes Add an analysis method, including the following steps:

[0022] S1: Sample preparation Collecting peripheral blood from patients with weight gain caused by the treatment of second-generation antipsychotic drugs for schizophrenia;

[0023]...

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Abstract

The invention discloses an analysis method for predicting body weight increase caused by treating schizophrenia through a second-generation antipsychotic based on the polygene combination interactiveeffect. The method comprises the steps that a sample is prepared for collecting peripheral blood of a patient with body weight increase caused by treating schizophrenia through the second-generation antipsychotic, a hypotonic salt fractionation method is used for extracting a genome DNA sample; a MODLI-TOF flight mass spectrum detecting method is used for performing genetic typing of a 5-HT2CR gene, a histamine 1 receptor gene, an oxytocin gene, an NPY / R gene, a Leptin gene, an adiponectin gene, an FGF21 gene and a FGF23 gene; data analysis and extraction are performed, instrument original data is aligned, data with no noise interference for statistic analysis is obtained, a generalized multi-factor dimension reduction method is used for performing the quantitative trait gene-gene interaction effect, crossed verification is further applied, and the gene interaction effect is used for predicting body weight increase. By adopting the generalized multi-factor dimension reduction method, the continuous ending variable is processed, covariance is introduced, and the method has the advantages of greatly enlarging the application range and greatly increasing the prediction accuracy.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an analysis method for predicting weight gain in the treatment of schizophrenia by second-generation antipsychotic drugs based on multi-gene combination interaction. Background technique [0002] Second-generation anti-schizophrenia drugs often lead to abnormal glucose and lipid metabolism, obesity and other estrogen-like side effects, such as lactation, Adam's apple shrinkage, and erectile dysfunction, which reduce patients' medication compliance and quality of life. Excessive weight gain may increase cardiovascular and diabetes-related morbidity and mortality, and increase the risk of metabolic syndrome in schizophrenia. [0003] At present, multiple gene genetic polymorphisms have been found to be associated with weight gain caused by second-generation antipsychotic drugs at home and abroad. For the prediction of weight gain in the treatment of chronic schizophrenia with seco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G16B20/00
CPCC12Q1/6883C12Q2600/106C12Q2600/156G16B20/00
Inventor 王帆李慧刘彦隆康毅敏
Owner SECOND AFFILIATED HOSPITAL OF XINJIANG MEDICAL UNIV
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