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Urticaria preparation containing active ingredient of cannabidiol CBD and preparation method thereof

A technology of cannabidiol and active ingredients, applied in the field of urticaria preparations and preparation thereof, achieves the effects of improving stability, fast onset time and obvious therapeutic effect

Inactive Publication Date: 2019-10-08
云南辰锦威生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the effects of treating epilepsy (CN103826621A), brain tumor (CN102083426B), mental illness (CN101939017B), but there is no literature report on the effect on urticaria

Method used

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  • Urticaria preparation containing active ingredient of cannabidiol CBD and preparation method thereof
  • Urticaria preparation containing active ingredient of cannabidiol CBD and preparation method thereof
  • Urticaria preparation containing active ingredient of cannabidiol CBD and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method for urticaria preparation containing cannabidiol CBD active ingredient, through the following steps:

[0036] (1) Prepare raw materials according to the following mass percentages:

[0037]

[0038] The Chuanqiong extract is subjected to the following operations: pulverize Chuanqiong, add 20 times the mass of water, soak for 4 hours, distill with a steam distillation device for 8 hours, collect Chuanqiong water extract and concentrate under reduced pressure to obtain Chuanqiong Extraction thing;

[0039] The Scutellaria baicalensis extract is obtained through the following operations: Weigh the washed and dried Scutellaria baicalensis raw medicinal materials, crush them, pass through a 20-mesh sieve, use 9 times the amount of pharmaceutical grade ethanol to reflux extract twice, each time for 1 hour, filter, and combine the filtrates , recover ethanol until there is no alcohol smell, transfer out the remaining water-soluble matter with appropria...

Embodiment 2

[0046] A preparation method for urticaria preparation containing cannabidiol CBD active ingredient, through the following steps:

[0047] (1) Prepare raw materials according to the following mass percentages:

[0048]

[0049]

[0050] The preparation of the Chuanqiong extract, Scutellaria baicalensis extract, and white moss bark extract is the same as in Example 1;

[0051] (2) Heat the peppermint oil in a water bath at 67°C for 10 minutes until the temperature of the peppermint oil reaches 67°C, then add cannabidiol to the peppermint oil, and dissolve the cannabidiol completely at a stirring speed of 10r / s After that, it was placed at room temperature to obtain material A;

[0052] (3) Add castor oil polyoxyethylene ether, span-80, and sorbitol to material A and mix evenly, then add some water, stir the mixture at a speed of 40r / s until completely dissolved, and obtain material B;

[0053] (4) Refrigerate material B at 5°C for 10 hours, filter, collect the filtrate, ...

Embodiment 3

[0056] A preparation method for urticaria preparation containing cannabidiol CBD active ingredient, through the following steps:

[0057] (1) Prepare raw materials according to the following mass percentages:

[0058]

[0059] The preparation of the Chuanqiong extract, Scutellaria baicalensis extract, and white moss bark extract is the same as in Example 1;

[0060] (2) Heat the peppermint oil in a water bath at 30-67°C for 15 minutes. After the temperature of the peppermint oil reaches 45°C, add cannabidiol to the peppermint oil, and make the cannabidiol After completely dissolving, place it at room temperature to obtain material A;

[0061] (3) Add castor oil polyoxyethylene ether, span-80, and sorbitol to material A and mix evenly, then add some water, stir the mixture at a speed of 20 r / s until completely dissolved, and obtain material B;

[0062] (4) Refrigerate material B at 4°C for 12 hours, filter, collect the filtrate, and obtain material C;

[0063] (5) Add pot...

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Abstract

The invention discloses an urticaria preparation containing an active ingredient of cannabidiol CBD and a preparation method thereof. The urticaria preparation comprises the following raw materials bymass percentages: 5-20% of cannabisdiol CBD, 0.1-5% of a Ligusticum chuanxiong Hort extract, 1-6%of a Scutellaria baicalensis extract, 0.5-5% of a cortex dictamni extract, 1-10% of polyoxyethylene castor oil, 1-5% of span-80, 1-5% of sorbitol, 1-10% of peppermint oil, 0.02-0.1% of potassium sorbate, and the balance of water. The urticaria preparation can quickly suppress itching for acute and chronic urticaria, does not cause skin allergy, has no toxic side effects, and has obvious therapeutic effects. The urticaria preparation prepared by the method of the invention can maximize the efficacyand improve the stability, and the synergistic effect of the cannabidiol CBD and the Ligusticum chuanxiong Hort extract, the Scutellaria baicalensis extract and the cortex dictamni extract, the drugmaximum efficacy can be exerted, the drug is absorbed quickly, and the onset time is fast after administration, the drug is convenient to be used, and the preparation is easily absorbed by the affected part or the lesion.

Description

technical field [0001] The invention relates to an urticaria preparation containing cannabidiol CBD active ingredient and a preparation method thereof, belonging to the field of biotechnology. Background technique [0002] Urticaria, known as addiction rash in traditional Chinese medicine, is a skin, mucous membrane or vascular reactive allergic disease caused by complex etiology. The types of urticaria include: cold urticaria, protein allergic urticaria, skin scratch rash, papular urticaria, allergic urticaria, cholinergic urticaria, acute urticaria, chronic urticaria, etc. The main clinical manifestations are , First, the skin feels itchy, and after scratching, red wheals appear on the skin. This red wheal comes and goes quickly, and can disappear by itself without leaving any traces after subsiding, but the condition is prone to repeated attacks. Due to changes in environmental factors, the number of patients suffering from urticaria is increasing day by day, and the res...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61P17/00A61P37/08A61K31/05
CPCA61K31/05A61K36/236A61K36/539A61K36/75A61P17/00A61P37/08A61K2300/00
Inventor 李映波冯红农春秋孙笠雯罗凡雅
Owner 云南辰锦威生物科技有限公司
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