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Preparation for treating rhinitis containing active ingredients of cannabinoid (CBD) and preparation method thereof

A technology of cannabidiol and active ingredients, applied in sprays for treating rhinitis, rhinitis sprays containing cannabidiol CBD active ingredients and its preparation field, which can solve problems such as inability to use long-term medication, unsatisfactory effects, and temporary cures rather than root causes , to achieve the effect of convenient medication, fast onset time and rapid drug absorption

Pending Publication Date: 2019-09-24
云南辰锦威生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the curative effect of Western medicine is good, but the side effects are large, and it cannot be used for a long time. For rhinitis, a disease that is easy to occur, it often treats the symptoms but not the root cause. In addition, the medicine for treating rhinitis will be metabolized by the liver after being inhaled. The effect is not long-lasting and the effect is not ideal
[0003] Cannabidiol CBD is an active ingredient extracted from natural hemp plants, and there is no literature report on its effect on rhinitis

Method used

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  • Preparation for treating rhinitis containing active ingredients of cannabinoid (CBD) and preparation method thereof
  • Preparation for treating rhinitis containing active ingredients of cannabinoid (CBD) and preparation method thereof
  • Preparation for treating rhinitis containing active ingredients of cannabinoid (CBD) and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Prepare raw materials according to the following mass percentages

[0034]

[0035] The Gastrodia elata extract is subjected to the following operations: adding 5 times the mass of Gastrodia elata powder to ethanol with a concentration of 95v / v% and stirring for 60 minutes, then adding ethanol with the same concentration and 10 times the mass of Gastrodia elata powder to soak for 12 hours, and percolating , collecting the filtrate, and concentrating the filtrate under reduced pressure into an extract to obtain the Gastrodia elata extract;

[0036] The Panax notoginseng extract is subjected to the following operations: add 10 times the mass of Panax notoginseng powder to the concentration of 95v / v% ethanol for ultrasonic extraction twice, each time for 20min, filter, combine the filtrates twice, and depressurize the filtrate Concentrate into an extract to obtain the Radix Notoginseng extract;

[0037] The Rhizoma Polygonatum extract is subjected to the following ...

Embodiment 2

[0043] (1) Prepare raw materials according to the following mass percentages:

[0044]

[0045] The preparation of the Gastrodia elata extract, Radix Notoginseng extract, Polygonatum extract is the same as in Example 1;

[0046] (2) Mix Gastrodia elata extract, Panax notoginseng extract and Polygonatum extract, add appropriate amount of water and mix evenly to obtain material A;

[0047] (3) Mix polyoxyethylene hydrogenated castor oil, glycerin, and rapeseed oil, heat to 50°C, then add cannabidiol CBD extract to the mixed oil, and make cannabis Completely dissolve the diphenol CBD extract in the mixed oil, then add an appropriate amount of water, and stir at a speed of 10r / s until the oil-soluble matter is completely dissolved in the water to obtain material B;

[0048] (4) Mix material B in step (3) and material A in step (2) evenly, refrigerate at 4°C for 12 hours, filter, collect the filtrate, and obtain material C;

[0049] (5) Add sorbic acid to the material C to adj...

Embodiment 3

[0051] (1) Prepare raw materials according to the following mass percentages:

[0052]

[0053] The Gastrodia elata extract, Radix Notoginseng extract, Polygonatum extract are commercially available products;

[0054] (2) Mix Gastrodia elata extract, Panax notoginseng extract and Polygonatum extract, add appropriate amount of water and mix evenly to obtain material A;

[0055] (3) Mix polyoxyethylene hydrogenated castor oil, glycerin, and rapeseed oil, heat to 40°C, then add cannabidiol CBD extract to the mixed oil, and make cannabis Completely dissolve the diphenol CBD extract in the mixed oil, then add an appropriate amount of water, and stir at a speed of 20r / s until the oil-soluble matter is completely dissolved in the water to obtain material A;

[0056] (4) Mix material B in step (3) and material A in step (2) evenly, refrigerate at 4°C for 12 hours, filter, collect the filtrate, and obtain material C;

[0057] (5) Add sorbic acid to the material C to adjust the pH va...

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Abstract

The invention discloses a preparation for treating rhinitis containing active ingredients of cannabinoid (CBD) and a preparation method thereof. The preparation for treating rhinitis containing the active ingredients of cannabinoid (CBD) is prepared from the following raw materials in percentage by mass: 2-20% of cannabinoid (CBD), 0.2-1% of a rhizoma gastrodiae extract, 0.1-0.5% of a pseudo-ginseng extract, 0.1-0.6% of a rhizoma polygonati extract, 2-10% of hydrogenated castor oil with polyoxyethylene, 1-5% of 1,2-propanediol, 1-10% of glycerine, 1-10% of rapeseed oil, 0.2-1% of sorbic acid, and the balance of water; and the sum of the raw materials is 100%. The preparation for treating rhinitis is capable of treating symptoms of various kinds of rhinitis, including acute rhinitis, chronic rhinitis, sinusitis and the like. The preparation for treating rhinitis contains cannabinoid (CBD) as an active component, and combines auxiliary effects of nano-emulsion; so that, the functions of the cannabinoid (CBD) are enhanced with stability improved. Moreover, the cannabinoid (CBD) is used in cooperation with the rhizoma gastrodiae extract, the pseudo-ginseng extract and the rhizoma polygonati extract so as to synergistically take an effect; and thus, the prepared preparation for treating rhinitis is capable of uniformly playing the maximum effects, allowing rapid absorption, yielding faster results after administration, convenient to use, and easy for an affected area or a lesion to absorb. The preparation for treating rhinitis containing active ingredients of cannabinoid (CBD) is a medicine for external application.

Description

technical field [0001] The invention relates to a spray for treating rhinitis, in particular to a rhinitis spray containing cannabidiol CBD active ingredient and a preparation method thereof, belonging to the field of biotechnology. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity, which is the inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of nasal mucosa. The common symptoms of rhinitis are: acute rhinitis, chronic rhinitis, sinusitis, allergic rhinitis, drug-induced rhinitis, etc. The main symptoms are nasal congestion, nasal itching, sneezing, decreased sense of smell, dizziness and headache. The drugs used to treat rhinitis in the past include antihistamines such as chlorpheniramine, Xinminox, etc.; decongestants such as ephedri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K36/8988A61P11/02
CPCA61K31/05A61K36/8988A61K36/258A61K36/8969A61K9/0043A61P11/02A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 李映波冯红农春秋孙笠雯罗凡雅
Owner 云南辰锦威生物科技有限公司
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