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Calcium citrate/polylactic acid bone repair material prepared by melt blending method and application thereof

A calcium citrate, melt blending technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of acidity of degradation products, inflammation, etc., achieve good biocompatibility, promote growth, and have obvious composite effects Effect

Inactive Publication Date: 2019-08-27
CHENGDU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, during the degradation process of polylactic acid itself, the degradation products are acidic and easily cause inflammation in the body, which limits its application to a certain extent.

Method used

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  • Calcium citrate/polylactic acid bone repair material prepared by melt blending method and application thereof
  • Calcium citrate/polylactic acid bone repair material prepared by melt blending method and application thereof
  • Calcium citrate/polylactic acid bone repair material prepared by melt blending method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The calcium citrate / polylactic acid bone repair material prepared by the melt blending method provided in this example is composed of polylactic acid and calcium citrate, in terms of mass percentage, the content of calcium citrate is 20%, and the rest is polylactic acid; citric acid The calcium is calcium citrate tetrahydrate, and the molecular weight of polylactic acid is 200,000. The specific implementation steps are as follows:

[0027] (1) Weigh 8 grams of polylactic acid and 2 grams of calcium citrate with an electronic balance;

[0028] (2) Melt and blend the weighed polylactic acid and calcium citrate at 180°C, and stir to obtain a uniformly dispersed mixture; the stirring speed is 200r / min;

[0029] (3) The mixture was injected into the template, and after 3 minutes of natural cooling to room temperature, the calcium citrate / polylactic acid bone repair material prepared by melt blending was prepared.

[0030] figure 1 It is the XRD pattern of the calcium citr...

Embodiment 2

[0037] The calcium citrate / polylactic acid bone repair material prepared by the melt blending method in this embodiment is composed of polylactic acid and calcium citrate. In terms of mass percentage, the content of calcium citrate is 1%, and the rest is polylactic acid; calcium citrate is Calcium citrate tetrahydrate, the molecular weight of polylactic acid is 200,000.

[0038] (1) Take by weighing 9.9 grams of polylactic acid and 0.1 grams of calcium citrate with an electronic balance;

[0039] (2) Melt-blending the weighed polylactic acid and calcium citrate together at 180° C., and obtaining a uniformly dispersed mixture by stirring; the stirring speed is 100 r / min;

[0040] (3) The mixture was poured into the template, and allowed to cool naturally to room temperature for 5 minutes to prepare a calcium citrate / polylactic acid bone repair material prepared by the melt blending method.

[0041] The tensile strength and elastic modulus of the calcium citrate / polylactic acid...

Embodiment 3

[0044] The calcium citrate / polylactic acid bone repair material prepared by the melt blending method in this embodiment is composed of polylactic acid and calcium citrate. In terms of mass percentage, the content of calcium citrate is 10%, and the rest is polylactic acid; calcium citrate is Calcium citrate tetrahydrate, polylactic acid molecular weight 200,000

[0045] (1) Take 9 grams of polylactic acid and 1 gram of calcium citrate with an electronic balance;

[0046] (2) Melt blend the weighed polylactic acid and calcium citrate at 180°C, and disperse evenly under stirring to obtain a mixture; the stirring speed is 200r / min;

[0047] (3) The mixture was injected into the template, and after being cooled to room temperature, the calcium citrate / polylactic acid bone repair material prepared by the melt blending method was obtained.

[0048] The tensile strength and elastic modulus of the calcium citrate / polylactic acid bone repair material prepared by the melt blending metho...

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Abstract

The invention belongs to the field of medical materials for bone injury repair, and specifically relates to a calcium citrate / polylactic acid bone repair material prepared by a melt blending method and application thereof. to the invention provides the calcium citrate / polylactic acid bone repair material prepared by the melt blending method, as calcium citrate and polylactic acid have good affinity, the calcium citrate and the polylactic acid can form a uniformly-dispersed composite material, and have good mechanical properties and forming machining properties, and meanwhile, a combination ofthe calcium citrate and the polylactic acid can show good biocompatibility and biodegradability, and in a degradation process, a slightly alkaline environment of degradation of the calcium citrate cancounteract an acid environment brought by separate degradation of the polylactic acid, a stable and suitable calcium ion environment is provided, and a local high-calcium environment is created to promote the growth of new bone tissues. Meanwhile, the calcium citrate / polylactic acid bone repair material prepared by the melt blending method has good formability, the size and shape of the calcium citrate / polylactic acid bone repair material is convenient to be processed into sizes and shapes required by clinical application, and the calcium citrate / polylactic acid bone repair material can be used to be processed into bone lamellas, bone screws, interbody fusion cages and the like required by orthopedic internal fixation. The calcium citrate / polylactic acid bone repair material can further regulate and control the degradation rate of composite materials through adjusting the molecular weight of the polylactic acid so as to meet the requirements of bone injury repair with different healing time.

Description

technical field [0001] The invention relates to a calcium citrate / polylactic acid bone repair material prepared by a melt blending method and an application thereof, belonging to the field of biomedical materials for bone damage repair. Background technique [0002] With the advancement of science and technology, the medical level is constantly improving, and medical materials are getting more and more attention. Among them, the use of artificial bone substitute materials to repair and replace bone defects has become the research focus in the field of medical orthopedics. It is an effective method for bone defects, bone tumors, osteomyelitis and other orthopedic diseases. An ideal bone repair material should have good matrix adaptability (biocompatibility), suitable mechanical properties, and good osteoinductive and conductive properties, which can promote the growth of new bone tissue and induce the formation of osteoblasts. It must have good formability and be easy to pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/54A61L27/18
CPCA61L27/18A61L27/50A61L27/54A61L2300/102A61L2300/412A61L2430/02C08L67/04
Inventor 李峻峰肖逸菲马悦王皓王立邹琴张佩聪赖雪飞
Owner CHENGDU UNIVERSITY OF TECHNOLOGY
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